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Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients

  • Authors:
    • Yifen Wu
    • Ning Zhang
    • Yifu Wu
    • Yanping Zheng
    • Xiaoen You
    • Zhuo Cao
    • Yaqi Xu
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Jinhua Guangfu Hospital, Jinhua, Zhejiang 321000, P.R. China, Department of Nursing, Zhejiang Jinhua Guangfu Hospital, Jinhua, Zhejiang 321000, P.R. China, Department of Burn and Plastic Surgery, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China, Department of Respiration, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 975-978
    |
    Published online on: May 18, 2016
       https://doi.org/10.3892/etm.2016.3362
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Abstract

The effect of different vasoactive drugs on the pH [intracellular pH (pHi)] of gastric mucosa in patients with septic shock was evaluated in the present study. According to the vasoactive drugs applied, 48 patients with septic shock were divided into 3 groups: A, B and C, with 16 cases each. Cases of group A were treated with dopamine, those of group B with norepinephrine while those of group C were treated with norepinephrine plus dobutamine. The changes of pH of gastric mucosa were observed before treatment (baseline) and 6, 12, 24 and 48 h after treatment, and the hemodynamic indicators were observed before treatment (baseline) and 6 h after administration. The gastric mucosal pH was not significantly different between two of the three groups before treatment (each at P>0.05). The gastric mucosal pH of group A did not change 6, 12, 24 and 48 h after treatment with drugs compared with the baseline (all at P>0.05), while the gastric mucosal pH in groups B and C were each statistically higher at the time points of 6, 12, 24 and 48 h after treatment with drugs compared with the respective baselines (all at P<0.05). Following treatment with drugs, the gastric mucosal pH of group C at all the time points of 6, 12, 24 and 48 h after treatment were significantly higher than those of groups A and B at the same time points after treatment, while there were some statistical differences between groups A and B at these time points (6, 12, 24 and 48 h after treatment; P<0.05). The hemodynamic indicators of the patients before treatment were not significantly different between two of the three groups (all at P>0.05). Compared with the baseline values, the mean arterial pressure and the cardiac index of each group after treatment were significantly increased, the pulmonary capillary wedge pressure and the central venous pressure of groups B and C significantly increased (all at P<0.05) and the heart rate of group A was significantly increased (P<0.05). In conclusion, the gastric mucosal pH of the septic shock patients was increased when treated with norepinephrine or with dobutamine. Additionally, the gastric mucosal pH was significantly higher when the patients were treated with dobutamine and norepinephrine in combination than with norepinephrine or dopamine alone. Dopamine, norepinephrine and dobutamine can improve the systemic hemodynamic conditions in patients with septic shock.
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Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Zhang N, Wu Y, Zheng Y, You X, Cao Z and Xu Y: Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients. Exp Ther Med 12: 975-978, 2016.
APA
Wu, Y., Zhang, N., Wu, Y., Zheng, Y., You, X., Cao, Z., & Xu, Y. (2016). Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients. Experimental and Therapeutic Medicine, 12, 975-978. https://doi.org/10.3892/etm.2016.3362
MLA
Wu, Y., Zhang, N., Wu, Y., Zheng, Y., You, X., Cao, Z., Xu, Y."Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients". Experimental and Therapeutic Medicine 12.2 (2016): 975-978.
Chicago
Wu, Y., Zhang, N., Wu, Y., Zheng, Y., You, X., Cao, Z., Xu, Y."Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients". Experimental and Therapeutic Medicine 12, no. 2 (2016): 975-978. https://doi.org/10.3892/etm.2016.3362
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Zhang N, Wu Y, Zheng Y, You X, Cao Z and Xu Y: Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients. Exp Ther Med 12: 975-978, 2016.
APA
Wu, Y., Zhang, N., Wu, Y., Zheng, Y., You, X., Cao, Z., & Xu, Y. (2016). Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients. Experimental and Therapeutic Medicine, 12, 975-978. https://doi.org/10.3892/etm.2016.3362
MLA
Wu, Y., Zhang, N., Wu, Y., Zheng, Y., You, X., Cao, Z., Xu, Y."Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients". Experimental and Therapeutic Medicine 12.2 (2016): 975-978.
Chicago
Wu, Y., Zhang, N., Wu, Y., Zheng, Y., You, X., Cao, Z., Xu, Y."Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients". Experimental and Therapeutic Medicine 12, no. 2 (2016): 975-978. https://doi.org/10.3892/etm.2016.3362
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