Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy

Li,Hui; Liu,Fu-Yuan; Li,Xiao-Lan; Li,Xiao-Mei; Zhu,Lei

doi:10.3892/etm.2016.3363

August-2016 Volume 12 Issue 2

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August-2016 Volume 12 Issue 2

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Article Open Access

Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy

Authors:
- Hui Li
- Fu-Yuan Liu
- Xiao-Lan Li
- Xiao-Mei Li
- Lei Zhu
View Affiliations / Copyright

Affiliations: Department of Cardiovascularology, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei 441001, P.R. China

Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 979-982
|
Published online on: May 19, 2016

https://doi.org/10.3892/etm.2016.3363
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Abstract

The aim of the study was to compare the clinical effects of carvedilol and trimetazidine for the treatment of alcoholic cardiomyopathy. A total of 60 patients diagnosed with alcoholic cardiomyopathy were enrolled in the study. The patients were randomly divided into the carvedilol (n=20), trimetazidine (n=20) and control (n=20) groups. The patients in the control, carvedilol and trimetazidine groups were treated with conventional drugs, conventional drugs + carvedil and conventional drugs + trimetazidine respectively, for 12 weeks. The patients were compared for their heart functions [left ventricular ejection fraction (LVEF), C-reactive protein (CRP) and 6 min walking], heart rate, blood pressure and heart enlargement (cardiothoracic proportion and left ventricular diameter) before and after treatment. The parameters studied for heart functions, heart rate, blood pressure, heart enlargement, clinical effects before and after treatment were statistically insignificant (p>0.05). After treatment, the carvedilol and trimetazidine groups showed higher LVEF and CRP, longer walking distance in 6 min, as well as lower heart rate and blood pressure (both systolic and diastolic) compared to the control group. Similarly, the cardiothoracic proportion and left ventricular internal diameter for the carvedilol and trimetazidine groups was lower than those of the control group, with better clinical effects (p<0.05). In conclusion, the curative effects of the carvedilol and trimetazidine groups of alcoholic myocardiopathy similar. Both are safe agents that may improve the cardiac function and heart expansion of patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy

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