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Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice

  • Authors:
    • Lei Song
    • Zhongrui Zhang
    • Jinling Zhang
    • Xuebin Zhu
    • Lei He
    • Zhe Shi
    • Li Gao
    • Fumin Feng
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Coal Mine Health and Safety, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 889-894
    |
    Published online on: May 20, 2016
       https://doi.org/10.3892/etm.2016.3375
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Abstract

Liver injury is a major hindrance to the treatment of tuberculosis (TB) patients due to the primary side effects associated with anti‑TB drugs. Several investigations have identified sensitive biomarkers for the early diagnosis of anti-TB drug-induced liver injury (ADLI), including the use of microRNAs (miRNAs/miRs). However, the association between miR‑122/155 and ADLI remains unknown. Thus, the present study used reverse transcription‑quantitative polymerase chain reaction to observe changes in tissue miR‑122/155 expression levels during the course of liver injury in mice. Liver injury was induced by the administration of isoniazid (INH), a first‑line anti‑TB drug. miR‑122/155 expression levels were quantified at seven time points throughout 1 day (0.25, 0.75, 1.5, 6, 12, 18 and 24 h) based on the pharmacokinetics of INH in mice. Notably, over the timecourse of INH‑induced liver injury, the tissue miR‑122 expression level significantly decreased at 0.25 h, which is the peak concentration time of INH, compared with the control group (P<0.05). The change was more rapid than that of the serum aminotransferase and miR‑155, which were significantly increased at 0.75 h. In addition, the pathological score correlated with the ratio of miR-122/miR-155 (r=‑0.779; P<0.01). In conclusion, the miR‑122/155 ratio may be utilized as a sensitive biomarker for ADLI, which could contribute to the early diagnosis of patients following anti-TB treatment.
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View References

1 

Glaziou P, Falzon D, Floyd K and Raviglione M: Global epidemiology of tuberculosis. Semin Respir Crit Care Med. 34:3–16. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Shih TY, Young TH, Lee HS, Hsieh CB and Hu OY: Protective effects of kaempferol on isoniazid- and rifampicin-induced hepatotoxicity. AAPS J. 15:753–762. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Shi Q, Hong H, Senior J and Tong W: Biomarkers for drug-induced liver injury. Expert Rev Gastroenterol Hepatol. 4:225–234. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Zelber-Sagi S, Toker S, Armon G, Melamed S, Berliner S, Shapira I, Halpern Z, Santo E and Shibolet O: Elevated alanine aminotransferase independently predicts new onset of depression in employees undergoing health screening examinations. Psychol Med. 43:2603–2613. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Yang X, Greenhaw J, Shi Q, Su Z, Qian F, Davis K, Mendrick DL and Salminen WF: Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity. Toxicol Sci. 125:335–344. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Zhang B, Sun S, Shen L, Zu X, Chen Y, Hao J, Huang X and Feng F: DNA methylation in the rat livers induced by low dosage isoniazid treatment. Environ Toxicol Pharmacol. 32:486–490. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Duskova K, Nagilla P, Le HS, Iyer P, Thalamuthu A, Martinson J, Bar-Joseph Z, Buchanan W, Rinaldo C and Ayyavoo V: MicroRNA regulation and its effects on cellular transcriptome in human immunodeficiency virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts. BMC Infect Dis. 3:2502013. View Article : Google Scholar

8 

Mi SL, Zhang J, Zhang W and Huang RS: Circulating microRNAs as biomarkers for inflammatory diseases. Microrna. 2:64–72. 2013. View Article : Google Scholar

9 

Henderson MC and Azorsa DO: The genomic and proteomic content of cancer cell-derived exosomes. Front Oncol. 2:382012. View Article : Google Scholar : PubMed/NCBI

10 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Wu D and Murashov AK: Molecular mechanisms of peripheral nerve regeneration: Emerging roles of microRNAs. Front. 4:552013.

12 

Ulivi P, Foschi G, Mengozzi M, Scarpi E, Silvestrini R, Amadori D and Zoli W: Peripheral blood miR-328 expression as a potential biomarker for the early diagnosis of NSCLC. Int J Mol Sci. 14:10332–10342. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Sita-Lumsden A, Dart DA, Waxman J and Bevan CL: Circulating microRNAs as potential new biomarkers for prostate cancer. Br J Cancer. 108:1925–1930. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Giusti I, D'Ascenzo S and Dolo V: Microvesicles as potential ovarian cancer biomarkers. BioMed Res Int. 2013:7030482013. View Article : Google Scholar : PubMed/NCBI

15 

Wang B, Wang H and Yang Z: MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R. PLoS One. 7:e470532012. View Article : Google Scholar : PubMed/NCBI

16 

Tsai WC, Hsu SD, Hsu CS, Lai TC, Chen SJ, Shen R, Huang Y, Chen HC, Lee CH, Tsai TF, et al: MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest. 22:2884–2897. 2012. View Article : Google Scholar

17 

Arataki K, Hayes CN, Akamatsu S, Akiyama R, Abe H, Tsuge M, Miki D, Ochi H, Hiraga N, Imamura M, et al: Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B. J Med Virol. 85:789–798. View Article : Google Scholar : PubMed/NCBI

18 

Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, et al: Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology. 58:777–787. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Y, Jia Y, Zheng R, Guo Y, Wang Y, Guo H, Fei M and Sun S: Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases. Clin Chem. 56:1830–1838. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Lind EF and Ohashi PS: Mir-155, a central modulator of T-cell responses. Eur J Immunol. 44:11–15. 2014. View Article : Google Scholar : PubMed/NCBI

21 

McDaniel K, Herrera L, Zhou T, Francis H, Han Y, Levine P, Lin E, Glaser S, Alpini G and Meng F: The functional role of microRNAs in alcoholic liver injury. J Cell Mol Med. 18:197–207. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Wei Y, Nazari-Jahantigh M, Neth P, Weber C and Schober A: MicroRNA-126, −145, and −155: A therapeutic triad in atherosclerosis? Arterioscler Thromb Vasc Biol. 33:449–454. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Farooqi AA, Qureshi MZ, Coskunpinar E, Naqvi SK, Yaylim I and Ismail M: miR-421, miR-155 and miR-650: Emerging trends of regulation of cancer and apoptosis. Asian Pac J Cancer Prev. 15:1909–1912. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, Patel T, Schmittgen TD, Croce C, Ghoshal K and Jacob ST: Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. Hepatology. 50:1152–1161. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Pogribny IP, Starlard-Davenport A, Tryndyak VP, Han T, Ross SA, Rusyn I and Beland FA: Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, asnd miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest. 90:1437–1446. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Guan TM, Liu DC, Wang JF, Cai S, Lin MJ, Lu RR, Wu KF, Ma XL, Wu T and Li WD: Protective effect of extract from fruit of Clausena lansium (Lour.) Skeels against acute alcohol-induced hepatotoxicity in mice. Zhong Guo Yao Li Xue Yu Du Li Xue Za Zhi. 26:829–834. 2012.(In Chinese).

28 

Le HS and Bar-Joseph Z: Integrating sequence, expression and interaction data to determine condition-specific miRNA regulation. Bioinformatics. 29:i89–i97. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Hou YN, Zhang XL and Wu HH: Effect of rifampicin and isoniazid coadministration on the metabolism and pharmacokinetics of isoniazid in mice. Jie Fang Jun Yao Xue Xue Bao. 27:23–26. 2011.(In Chinese).

30 

Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, Hood LE and Galas DJ: Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci USA. 106:4402–4407. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Ceppi M, Pereira PM, Dunand-Sauthier I, Barras E, Reith W, Santos MA and Pierre P: MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci USA. 106:2735–2740. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Lu F, Weidmer A, Liu CG, Volinia S, Croce CM and Lieberman PM: Epstein-Barr virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence. J Virol. 82:10436–10443. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Kuo YC, Li YS, Zhou J, Shih YR, Miller M, Broide D, Lee OK and Chien S: Human mesenchymal stem cells suppress the stretch-induced inflammatory miR-155 and cytokines in bronchial epithelial cells. PLoS One. 8:e713422013. View Article : Google Scholar : PubMed/NCBI

34 

Nazari-Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen RR, Heyll K, Gremse F, Kiessling F, Grommes J, et al: MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Invest. 122:4190–4202. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA and Croce CM: Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol. 179:5082–5089. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Miller AM, Gilchrist DS, Nijjar J, Araldi E, Ramirez CM, Lavery CA, Fernández-Hernando C, McInnes IB and Kurowska-Stolarska M: MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS One. 8:e723242013. View Article : Google Scholar : PubMed/NCBI

37 

Senior JR: Alanine aminotransferase: A clinical and regulatory tool for detecting liver injury-past, present, and future. Clin Pharmacol Ther. 92:332–339. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Yamaura Y, Nakajima M, Takagi S, Fukami T, Tsuneyama K and Yokoi T: Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis. PLoS One. 7:e302502012. View Article : Google Scholar : PubMed/NCBI

39 

An FM, Yu DS, Xie Q, Gong BD, Wang H, Guo Q and Yu H: The role of miR-122 expression during the acute liver failure in mice induced by D-GalN/LPS. Zhonghua Gan Zang Bing Za Zhi. 18:527–532. 2010.(In Chinese). PubMed/NCBI

40 

Jopling C: Liver-specific microRNA-122: Biogenesis and function. RNA Biol. 9:137–142. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Wagner AE, Boesch-Saadatmandi C, Dose J, Schultheiss G and Rimbach G: Anti-inflammatory potential of allyl-isothiocyanate - role of Nrf2, NF-(k) B and microRNA-155. J Cell Mol Med. 16:836–843. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Song L, Zhang Z, Zhang J, Zhu X, He L, Shi Z, Gao L and Feng F: Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice. Exp Ther Med 12: 889-894, 2016.
APA
Song, L., Zhang, Z., Zhang, J., Zhu, X., He, L., Shi, Z. ... Feng, F. (2016). Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice. Experimental and Therapeutic Medicine, 12, 889-894. https://doi.org/10.3892/etm.2016.3375
MLA
Song, L., Zhang, Z., Zhang, J., Zhu, X., He, L., Shi, Z., Gao, L., Feng, F."Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice". Experimental and Therapeutic Medicine 12.2 (2016): 889-894.
Chicago
Song, L., Zhang, Z., Zhang, J., Zhu, X., He, L., Shi, Z., Gao, L., Feng, F."Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice". Experimental and Therapeutic Medicine 12, no. 2 (2016): 889-894. https://doi.org/10.3892/etm.2016.3375
Copy and paste a formatted citation
x
Spandidos Publications style
Song L, Zhang Z, Zhang J, Zhu X, He L, Shi Z, Gao L and Feng F: Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice. Exp Ther Med 12: 889-894, 2016.
APA
Song, L., Zhang, Z., Zhang, J., Zhu, X., He, L., Shi, Z. ... Feng, F. (2016). Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice. Experimental and Therapeutic Medicine, 12, 889-894. https://doi.org/10.3892/etm.2016.3375
MLA
Song, L., Zhang, Z., Zhang, J., Zhu, X., He, L., Shi, Z., Gao, L., Feng, F."Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice". Experimental and Therapeutic Medicine 12.2 (2016): 889-894.
Chicago
Song, L., Zhang, Z., Zhang, J., Zhu, X., He, L., Shi, Z., Gao, L., Feng, F."Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice". Experimental and Therapeutic Medicine 12, no. 2 (2016): 889-894. https://doi.org/10.3892/etm.2016.3375
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