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Case Report Open Access

Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report

  • Authors:
    • Wen‑Qing Ren
    • Feng Yin
    • Jian‑Ning Zhang
    • Wang‑Sheng Lu
    • Ying‑Kui Liang
    • Josefin Adlerberth
    • Zeng‑Min Tian
  • View Affiliations / Copyright

    Affiliations: Institute of Neurosurgery, The PLA Navy General Hospital, Beijing 100048, P.R. China, PET Center, The PLA Navy General Hospital, Beijing 100048, P.R. China, Department of Pure and Applied Biochemistry, Lund University, Lund, 22100 Scania, Sweden
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 661-666
    |
    Published online on: May 25, 2016
       https://doi.org/10.3892/etm.2016.3392
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Abstract

Primary torsion dystonia (PTD) occurs due to a genetic mutation and often advances gradually. Currently, there is no therapy available that is able to inhibit progression. Neural stem cells (NSCs) are being investigated as potential therapies for neurodegenerative diseases, such as stroke and trauma. The present study evaluated the clinical effectiveness of NSC transplantation in an 18-year-old male patient with PTD, to assess the ability of this therapy to inhibit PTD progression. Genetic testing of the patient revealed a mutation in the torsion dystonia‑1 (DYT1) gene (907‑909 delGAG). NSCs were bilaterally implanted in the globus pallidus of the patient through stereotactic surgery. Prior to surgery, the patient's Burke-Fahn-Marsden dystonia movement score (BFMDMS) was 21, which progressively decreased after surgery to 18, 17, 15 and 13 at 1, 2, 3 and 4 postoperative years, respectively. BFMDMS was improved by 38.1% over the 4 postoperative years. Although computed tomography and magnetic resonance imaging examinations showed no significant changes prior to and following surgery, postoperative brain positron emission tomography scans revealed increased glucose metabolism in the transplanted region. The clinical efficacy of NSC transplantation in this patient suggests its potential for the treatment of DYT1‑positive patients with PTD.
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Copy and paste a formatted citation
Spandidos Publications style
Ren WQ, Yin F, Zhang JN, Lu WS, Liang YK, Adlerberth J and Tian ZM: Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report. Exp Ther Med 12: 661-666, 2016.
APA
Ren, W., Yin, F., Zhang, J., Lu, W., Liang, Y., Adlerberth, J., & Tian, Z. (2016). Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report. Experimental and Therapeutic Medicine, 12, 661-666. https://doi.org/10.3892/etm.2016.3392
MLA
Ren, W., Yin, F., Zhang, J., Lu, W., Liang, Y., Adlerberth, J., Tian, Z."Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report". Experimental and Therapeutic Medicine 12.2 (2016): 661-666.
Chicago
Ren, W., Yin, F., Zhang, J., Lu, W., Liang, Y., Adlerberth, J., Tian, Z."Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report". Experimental and Therapeutic Medicine 12, no. 2 (2016): 661-666. https://doi.org/10.3892/etm.2016.3392
Copy and paste a formatted citation
x
Spandidos Publications style
Ren WQ, Yin F, Zhang JN, Lu WS, Liang YK, Adlerberth J and Tian ZM: Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report. Exp Ther Med 12: 661-666, 2016.
APA
Ren, W., Yin, F., Zhang, J., Lu, W., Liang, Y., Adlerberth, J., & Tian, Z. (2016). Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report. Experimental and Therapeutic Medicine, 12, 661-666. https://doi.org/10.3892/etm.2016.3392
MLA
Ren, W., Yin, F., Zhang, J., Lu, W., Liang, Y., Adlerberth, J., Tian, Z."Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report". Experimental and Therapeutic Medicine 12.2 (2016): 661-666.
Chicago
Ren, W., Yin, F., Zhang, J., Lu, W., Liang, Y., Adlerberth, J., Tian, Z."Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report". Experimental and Therapeutic Medicine 12, no. 2 (2016): 661-666. https://doi.org/10.3892/etm.2016.3392
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