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Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells

  • Authors:
    • Jian‑Ying Tian
    • Wei‑Wei Chen
    • Jing Cui
    • Hao Wang
    • Ci Chao
    • Zhi‑Yan Lu
    • Yong‑Yi Bi
  • View Affiliations / Copyright

    Affiliations: Department of Health, Labor Health and Environment, School of Public Health, Wuhan University, Wuhan, Hubei 430072, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 683-689
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    Published online on: June 2, 2016
       https://doi.org/10.3892/etm.2016.3415
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Abstract

The aim of the present study was to observe the effects of a general extract of Lycium bararum polysaccharides (LBPs) on methylmercury (MeHg)-induced damage in hippocampus neural stem cells (hNSCs). The hippocampal tissues of embryonic day 16 Sprague-Dawley rats were extracted for the isolation, purification and cloning of hNSCs. Following passage and proliferation for 10 days, the cells were allocated at random into the following groups: Control, LBPs, MeHg and MeHg + LBPs. MTT and microtubule‑associated protein 2 (MAP‑2)/glial fibrillary acidic protein/Hoechst immunofluorescence tests were performed to detect the differentiation and growth of hNSCs in the various groups. The differentiation rate of MeHg-treated hNSCs and the perimeter of MAP‑2‑positive neurons were 3.632±0.63% and 62.36±5.58 µm, respectively, significantly lower compared with the control group values of 6.500±0.81% and 166±8.16 µm (P<0.05). Furthermore, the differentiation rate and the perimeter of MAP‑2‑positive neurons in LBPs groups cells was 7.75±0.59% and 253.3±11.21 µm, respectively, significantly higher compared with the control group (P<0.05). The same parameters in the MeHg + LBPs group were 5.92±0.98% and 111.9±6.07 µm, respectively, significantly higher than the MeHg group (P<0.05). The astrocyte differentiation rates in the MeHg and MeHg + LBPs group were 41.19±2.14 and 34.58±1.70, respectively (P<0.05). These results suggest that LBPs may promote the generation and development of new neurons and inhibit the MeHg‑induced abnormal differentiation of astrocytes. Thus, LBPs may be considered to be a potential new treatment for MeHg-induced neurotoxicity in hNSCs.
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1 

Schaeffer EL, Novaes BA, da Silva ER, Skaf HD and Mendes-Neto AG: Strategies to promote differentiation of newborn neurons into mature functional cells in Alzheimer brain. Prog Neuropsychopharmacol Biol Psychiatry. 33:1087–1102. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Llorens-Martín M, Blazquez-Llorca L, Benavides-Piccione R, Rabano A, Hernandez F, Avila J and DeFelipe J: Selective alterations of neurons and circuits related to early memory loss in Alzheimer's disease. Front Neuroanat. 8:382014.PubMed/NCBI

3 

Desplats P, Patel P, Kosberg K, Mante M, Patrick C, Rockenstein E, Fujita M, Hashimoto M and Masliah E: Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease. Mol Neurodegener. 7:492012. View Article : Google Scholar : PubMed/NCBI

4 

Ding D, Moskowitz SI, Li R, Lee SB, Esteban M, Tomaselli K, Chan J and Bergold PJ: Acidosis induces necrosis and apoptosis of cultured hippocampal neurons. Exp Neurol. 162:1–12. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Boischio A: Developmental neurotoxicity: Methylmercury and prenatal exposure protection in the context of the Minamata Convention. Rev Panam Salud Publica. 38:243–247. 2015.PubMed/NCBI

6 

Sheehan MC, Burke TA, Navas-Acien A, Breysse PN, McGready J and Fox MA: Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review. Bull World Health Organ. 92:254–269F. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Chen CY, Driscoll CT, Lambert KF, Mason RP and Sunderland EM: Connecting mercury science to policy: From sources to seafood. Rev Environ Health. 31:17–20. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Graham AM, Aiken GR and Gilmour CC: Dissolved organic matter enhances microbial mercury methylation under sulfidic conditions. Environ Sci Technol. 46:2715–2723. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Graham AM, Aiken GR and Gilmour CC: Effect of dissolved organic matter source and character on microbial Hg methylation in Hg-S-DOM solutions. Environ Sci Techno. 147:5746–5754. 2013. View Article : Google Scholar

10 

Clarkson TW, Vyas JB and Ballatori N: Mechanisms of mercury disposition in the body. Am J Ind Med. 50:757–764. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Burke K, Cheng Y, Li B, Petrov A, Joshi P, Berman RF, Reuhl KR and DiCicco-Bloom E: Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E. Neurotoxicology. 27:970–981. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Falluel-Morel A, Sokolowski K, Sisti HM, Zhou X, Shors TJ and Dicicco-Bloom E: Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis and severe learning deficits during puberty. J Neurochem. 103:1968–1981. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Haase H, Engelhardt G, Hebel S and Rink L: Mercuric ions inhibit mitogen-activated protein kinase dephosphorylation by inducing reactive oxygen species. Toxicol Aplli Pharmacol. 250:78–86. 2011. View Article : Google Scholar

14 

Sokolowski K, Falluel-Morel A, Zhou X and DiCicco-Bloom E: Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures. Neurotoxicology. 32:535–544. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Kino T: Stress, glucocorticoid hormones, and hippocampal neural progenitor cells: implications to mood disorders. Front Physiol. 6:2302015. View Article : Google Scholar : PubMed/NCBI

16 

Guo J, Wang J, Liang C, Yan J, Wang Y, Liu G, Jiang Z, Zhang L, Wang X, Wang Y, et al: proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro. Stem Cell Res. 11:874–887. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Cameron HA and Mckay RD: Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol. 435:406–417. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Ozeki A, Suzuki K, Suzuki M, Ozawa H and Yamashita S: Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation. Neuroreport. 23:290–293. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Domowicz MS, Henry JG, Wadlington N, Navarro A, Kraig RP and Schwartz NB: Astrocyte precursor response to embryonic brain injury. Brain Res. 1389:35–49. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Zhang J, Ji F, Liu Y, Lei X, Li H, Ji G, Yuan Z and Jiao J: Ezh2 regulates adult hippocampal neurogenesis and memory. J Neurosci. 34:5184–5199. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Christie KJ, Emery B, Denham M, Bujalka H, Cate HS and Turnley AM: Transcriptional regulation and specification of neural stem cells. Adv Exp Med Biol. 786:129–155. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Hodge RD, Nelson BR, Kahoud RJ, Yang R, Mussar KE, Reiner SL and Hevner RF: Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons. J Neurosci. 32:6275–6287. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Tian J, Luo Y, Chen W, Yang S, Wang H, Cui J, Lu Z, Lin Y and Bi Y: MeHg Suppressed neuronal potency of hippocampal NSCs contributing to the puberal spatial memory deficits. Biol Trace Elem Res. Jan 8–2016.(Epub ahead of print). View Article : Google Scholar

24 

Sokolowski K, Obiorah M, Robinson K, McCandlish E, Buckley B and DiCicco-Bloom E: Neural stem cell apoptosis after low-methylmercury exposures in postnatal hippocampus produce persistent cell loss and adolescent memory, deficits. Dev Neurobiol. 73:936–949. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Lam CS, Tipoe GL, So KF and Fung ML: Neuroprotective mechanism of Lycium barbarum polysaccharides against hippocampal-dependent spatial memory deficits in a rat model of obstructive sleep apnea. PLoS One. 10:e01179902015. View Article : Google Scholar : PubMed/NCBI

26 

Liu L, Lao W, Ji QS, Yang ZH, Yu GC and Zhong JX: Lycium barbarum polysaccharides protected human retinal pigment epithelial cells against oxidative stress-induced apoptosis. Int J Ophthalmol. 8:11–6. 2015.PubMed/NCBI

27 

Cheng J, Zhou ZW, Sheng HP, He LJ, Fan XW, He ZX, Sun T, Zhang X, Zhao RJ, Gu L, et al: An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. Drug Des Devel Ther. 9:33–78. 2014.PubMed/NCBI

28 

Lau BW, Lee JC, Li Y, Fung SM, Sang YH, Shen J, Chang RC and So KF: Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis. PLoS One. 7:e333742012. View Article : Google Scholar : PubMed/NCBI

29 

Seibenhener ML and Wooten MW: Isolation and culture of hippocampal neurons from prenatal mice. J Vis Exp. 65:36342012.PubMed/NCBI

30 

Moors M, Rockel TD, Abel J, Cline JE, Gassmann K, Schreiber T, Schuwald J, Weinmann N and Fritsche E: Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing. Environ Health Perspect. 117:1131–1138. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Piatti VC, Espósito MS and Schinder AF: The timing of neuronal development in adult hippocampal neurogenesis. Neuroscientist. 12:463–468. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Rolls A, Shechter R, London A, Ziv Y, Ronen A, Levy R and Schwartz M: Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol. 9:1081–1088. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Llorens-Martín M, Rábano A and Ávila J: The ever-changing morphology of hippocampal granule neurons in physiology and pathology. Front Neurosci. 9:5262016. View Article : Google Scholar : PubMed/NCBI

34 

Snyder JS, Hong NS, Mcdonald RJ and Wojtowicz JM: A role for adult neurogenesis in spatial long-term memory. Neuroscience. 130:843–852. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Ryan SM and Nolan YM: Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: Can exercise compensate? Neurosci Biobehav Rev. 61:121–131. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Jinno S: Aging affects new cell production in the adult hippocampus: A quantitative anatomic review. J Chem Neuroanat S0891-0618(15)00094-0. 2015. View Article : Google Scholar

37 

Mielke JG and Mealing GA: Cellular distribution of the nicotinic acetylcholine receptor alpha7 subunit in rat hippocampus. Neurosci Res. 65:296–306. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Januschke J and Näthke I: Stem cell decisions: A twist of fate or a niche market? Semin Cell Dev Biol. 34:116–123. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Abdel-Salam OM: Stem cell therapy for Alzheimer's disease. CNS Neurol Disord Drug Targets. 10:459–485. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Paul Hsu CH, Nance DM and Amagase H: A meta-analysis of clinical improvements of general well-being by a standardized Lycium barbarum. J Med Food. 15:1006–1014. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Yang D, Li SY, Yeung CM, Chang RC, So KF, Wong D and Lo AC: Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke. PLoS One. 7:e335962012. View Article : Google Scholar : PubMed/NCBI

42 

He M, Pan H, Chang RC, So KF, Brecha NC and Pu M: Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage. PLoS One. 9:e848002014. View Article : Google Scholar : PubMed/NCBI

43 

Chang RC and So KF: Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far? Cell Mol Neurobiol. 28:643–652. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Yang M, Ding J, Zhou X, Zhang X, Tao H, Wang Y and Li G: Effects of Lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat. Biomed Rep. 2:687–692. 2014.PubMed/NCBI

45 

Xiao J, Xing F, Huo J, Fung ML, Liong EC, Ching YP, Xu A, Chang RC, So KF and Tipoe GL: Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. Sci Rep. 4:55872014. View Article : Google Scholar : PubMed/NCBI

46 

Rui C, Yuxiang L, Yinju H, Qingluan Z, Yang W, Qipeng Z, Hao W, Lin M, Juan L, Chengjun Z, et al: Protective effects of Lycium barbarum polysaccharide on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion. J Mol Histol. 43:535–542. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Yu MS, Leung SK, Lai SW, Che CM, Zee SY, So KF, Yuen WH and Chang RC: Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against beta-amyloid peptide neurotoxicity. Exp Gerontol. 40:716–727. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Yu MS, Ho YS, So KF, Yuen WH and Chang RC: Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum. Int J Mol Med. 17:1157–1161. 2006.PubMed/NCBI

49 

Mi XS, Feng Q, Lo AC, Chang RC, Lin B, Chung SK and So KF: Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension. PLoS One. 7:e454692012. View Article : Google Scholar : PubMed/NCBI

50 

Ho YS, Yu MS, Yang XF, So KF, Yuen WH and Chang RC: Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons. J Alzheimers Dis. 19:813–827. 2010.PubMed/NCBI

51 

Ho YS, Yu MS, Yik SY, So KF, Yuen WH and Chang RC: Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons. Cell Mol Neurobiol. 29:1233–1244. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Clarkson TW and Strain JJ: Nutritional factors may modify the toxic action of methyl mercury in fish-eating populations. J Nutr. 133:1539S–1543S. 2003.PubMed/NCBI

53 

Byelashov OA, Sinclair AJ and Kaur G: Dietary sources, current intakes, and nutritional role of omega-3 docosapentaenoic acid. Lipid Technol. 27:79–82. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Ayyathan DM, Chandrasekaran R and Thiagarajan K: Neuroprotective effect of Brahmi, an ayurvedic drug against oxidative stress induced by methyl mercury toxicity in rat brain mitochondrial-enriched fractions. Nat Prod Res. 29:1046–1051. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Kaur P, Aschner M and Syversen T: Biochemical factors modulating cellular neurotoxicity of methylmercury. J Toxicol. 2011:7219872011. View Article : Google Scholar : PubMed/NCBI

56 

Wagner C, Vargas AP, Roos DH, Morel AF, Farina M, Nogueira CW, Aschner M and Rocha JB: Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices. Arch Toxicol. 84:89–97. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tian JY, Chen WW, Cui J, Wang H, Chao C, Lu ZY and Bi YY: Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells. Exp Ther Med 12: 683-689, 2016.
APA
Tian, J., Chen, W., Cui, J., Wang, H., Chao, C., Lu, Z., & Bi, Y. (2016). Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells. Experimental and Therapeutic Medicine, 12, 683-689. https://doi.org/10.3892/etm.2016.3415
MLA
Tian, J., Chen, W., Cui, J., Wang, H., Chao, C., Lu, Z., Bi, Y."Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells". Experimental and Therapeutic Medicine 12.2 (2016): 683-689.
Chicago
Tian, J., Chen, W., Cui, J., Wang, H., Chao, C., Lu, Z., Bi, Y."Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells". Experimental and Therapeutic Medicine 12, no. 2 (2016): 683-689. https://doi.org/10.3892/etm.2016.3415
Copy and paste a formatted citation
x
Spandidos Publications style
Tian JY, Chen WW, Cui J, Wang H, Chao C, Lu ZY and Bi YY: Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells. Exp Ther Med 12: 683-689, 2016.
APA
Tian, J., Chen, W., Cui, J., Wang, H., Chao, C., Lu, Z., & Bi, Y. (2016). Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells. Experimental and Therapeutic Medicine, 12, 683-689. https://doi.org/10.3892/etm.2016.3415
MLA
Tian, J., Chen, W., Cui, J., Wang, H., Chao, C., Lu, Z., Bi, Y."Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells". Experimental and Therapeutic Medicine 12.2 (2016): 683-689.
Chicago
Tian, J., Chen, W., Cui, J., Wang, H., Chao, C., Lu, Z., Bi, Y."Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells". Experimental and Therapeutic Medicine 12, no. 2 (2016): 683-689. https://doi.org/10.3892/etm.2016.3415
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