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Article

A novel method for right one-lung ventilation modeling in rabbits

  • Authors:
    • Ze‑Ping Xu
    • Lian‑Bing Gu
    • Qing‑Ming Bian
    • Peng‑Yi Li
    • Li‑Jun Wang
    • Xiao‑Xiang Chen
    • Jing‑Yuan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Jiangsu Cancer Hospital, Jiangsu Cancer Institute, Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China, Department of Gynecology, Jiangsu Cancer Hospital, Jiangsu Cancer Institute, Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China, Department of Pathology, Jiangsu Cancer Hospital, Jiangsu Cancer Institute, Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China
  • Pages: 1213-1219
    |
    Published online on: June 7, 2016
       https://doi.org/10.3892/etm.2016.3434
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Abstract

There is no standard method by which to establish a right one-lung ventilation (OLV) model in rabbits. In the present study, a novel method is proposed to compare with two other methods. After 0.5 h of baseline two-lung ventilation (TLV), 40 rabbits were randomly divided into sham group (TLV for 3 h as a contrast) and three right-OLV groups (right OLV for 3 h with different methods): Deep intubation group, clamp group and blocker group (deeply intubate the self-made bronchial blocker into the left main bronchus, the novel method). These three methods were compared using a number of variables: Circulation by heart rate (HR), mean arterial pressure (MAP); oxygenation by arterial blood gas analysis; airway pressure; lung injury by histopathology; and time, blood loss, success rate of modeling. Following OLV, compared with the sham group, arterial partial pressure of oxygen and arterial hemoglobin oxygen saturation decreased, peak pressure increased and lung injury scores were higher in three OLV groups at 3 h of OLV. All these indexes showed no differences between the three OLV groups. During right‑OLV modeling, less time was spent in the blocker group (6±2 min), compared with the other two OLV groups (13±4 min in deep intubation group, P<0.05; 33±9 min in clamp group, P<0.001); more blood loss was observed in clamp group (11.7±2.8 ml), compared with the other two OLV groups (2.3±0.5 ml in deep intubation group, P<0.001; 2.1±0.6 ml in blocker group, P<0.001). The first-time and final success rate of modeling showed no differences among the three OLV groups. Deep intubation of the self‑made bronchial blocker into the left main bronchus is an easy, effective and reliable method to establish a right-OLV model in rabbits.
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Copy and paste a formatted citation
Spandidos Publications style
Xu ZP, Gu LB, Bian QM, Li PY, Wang LJ, Chen XX and Zhang JY: A novel method for right one-lung ventilation modeling in rabbits. Exp Ther Med 12: 1213-1219, 2016.
APA
Xu, Z., Gu, L., Bian, Q., Li, P., Wang, L., Chen, X., & Zhang, J. (2016). A novel method for right one-lung ventilation modeling in rabbits. Experimental and Therapeutic Medicine, 12, 1213-1219. https://doi.org/10.3892/etm.2016.3434
MLA
Xu, Z., Gu, L., Bian, Q., Li, P., Wang, L., Chen, X., Zhang, J."A novel method for right one-lung ventilation modeling in rabbits". Experimental and Therapeutic Medicine 12.2 (2016): 1213-1219.
Chicago
Xu, Z., Gu, L., Bian, Q., Li, P., Wang, L., Chen, X., Zhang, J."A novel method for right one-lung ventilation modeling in rabbits". Experimental and Therapeutic Medicine 12, no. 2 (2016): 1213-1219. https://doi.org/10.3892/etm.2016.3434
Copy and paste a formatted citation
x
Spandidos Publications style
Xu ZP, Gu LB, Bian QM, Li PY, Wang LJ, Chen XX and Zhang JY: A novel method for right one-lung ventilation modeling in rabbits. Exp Ther Med 12: 1213-1219, 2016.
APA
Xu, Z., Gu, L., Bian, Q., Li, P., Wang, L., Chen, X., & Zhang, J. (2016). A novel method for right one-lung ventilation modeling in rabbits. Experimental and Therapeutic Medicine, 12, 1213-1219. https://doi.org/10.3892/etm.2016.3434
MLA
Xu, Z., Gu, L., Bian, Q., Li, P., Wang, L., Chen, X., Zhang, J."A novel method for right one-lung ventilation modeling in rabbits". Experimental and Therapeutic Medicine 12.2 (2016): 1213-1219.
Chicago
Xu, Z., Gu, L., Bian, Q., Li, P., Wang, L., Chen, X., Zhang, J."A novel method for right one-lung ventilation modeling in rabbits". Experimental and Therapeutic Medicine 12, no. 2 (2016): 1213-1219. https://doi.org/10.3892/etm.2016.3434
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