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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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August-2016 Volume 12 Issue 2

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Thromboembolic events secondary to tirofiban-induced thrombocytopenia being treated with thrombopoietin: A case report

  • Authors:
    • Yanhua Li
    • Qiang Xu
    • Xinhong Guo

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, P.R. China
  • Pages: 1177-1180
    |
    Published online on: June 8, 2016
       https://doi.org/10.3892/etm.2016.3439
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Abstract

A 68-year-old man presented with acute coronary syndrome (ACS). The glycoprotein/IIb/IIIa receptor antagonist tirofiban was administered to the patient to treat a right coronary artery slow flow detected during percutaneous coronary intervention. The patient developed very severe thrombocytopenia 8 h after tirofiban infusion with no signs of bleeding. Antiplatelet medication was discontinued immediately, methylprednisolone was administered and platelets were transfused. Thrombopoietin (TPO) was also applied to the patient as recommended by a hematology consultant. As a result, the patient had in‑stent thrombosis and cerebral infarction, then another sirolimus‑eluting stent was implanted in the proximal right coronary artery and intensive anti‑platelet as well as intermittent dehydration to reduce intracranial pressure, and protection of the nervous system function treatment was also provided. The patient was left with a decreased muscle strength in the right limb muscle and fine movement disorder, which may have lead to a poor prognosis. To the best of our knowledge, this is the first case report of tirofiban‑induced severe thrombocytopenia with secondary in‑stent thrombosis and cerebral infarction from China. The experience of the diagnosis and treatment of this case may shed some light on the clinical use of TPO in tirofiban-induced thrombocytopenia.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Xu Q and Guo X: Thromboembolic events secondary to tirofiban-induced thrombocytopenia being treated with thrombopoietin: A case report. Exp Ther Med 12: 1177-1180, 2016.
APA
Li, Y., Xu, Q., & Guo, X. (2016). Thromboembolic events secondary to tirofiban-induced thrombocytopenia being treated with thrombopoietin: A case report. Experimental and Therapeutic Medicine, 12, 1177-1180. https://doi.org/10.3892/etm.2016.3439
MLA
Li, Y., Xu, Q., Guo, X."Thromboembolic events secondary to tirofiban-induced thrombocytopenia being treated with thrombopoietin: A case report". Experimental and Therapeutic Medicine 12.2 (2016): 1177-1180.
Chicago
Li, Y., Xu, Q., Guo, X."Thromboembolic events secondary to tirofiban-induced thrombocytopenia being treated with thrombopoietin: A case report". Experimental and Therapeutic Medicine 12, no. 2 (2016): 1177-1180. https://doi.org/10.3892/etm.2016.3439
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Xu Q and Guo X: Thromboembolic events secondary to tirofiban-induced thrombocytopenia being treated with thrombopoietin: A case report. Exp Ther Med 12: 1177-1180, 2016.
APA
Li, Y., Xu, Q., & Guo, X. (2016). Thromboembolic events secondary to tirofiban-induced thrombocytopenia being treated with thrombopoietin: A case report. Experimental and Therapeutic Medicine, 12, 1177-1180. https://doi.org/10.3892/etm.2016.3439
MLA
Li, Y., Xu, Q., Guo, X."Thromboembolic events secondary to tirofiban-induced thrombocytopenia being treated with thrombopoietin: A case report". Experimental and Therapeutic Medicine 12.2 (2016): 1177-1180.
Chicago
Li, Y., Xu, Q., Guo, X."Thromboembolic events secondary to tirofiban-induced thrombocytopenia being treated with thrombopoietin: A case report". Experimental and Therapeutic Medicine 12, no. 2 (2016): 1177-1180. https://doi.org/10.3892/etm.2016.3439
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