Cryptococcal meningitis initially presenting with eye symptoms in an immunocompetent patient: A case report

  • Authors:
    • Jun Li
    • Peipei Wang
    • Ling Ye
    • Yanfang Wang
    • Xiuzhen Zhang
    • Songping Yu
  • View Affiliations

  • Published online on: June 8, 2016     https://doi.org/10.3892/etm.2016.3440
  • Pages: 1119-1124
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Abstract

Although cryptococcal meningitis (CM) typically occurs in immunocompromised hosts, immunocompetent humans are susceptible to CM. In humans with an intact immune system, CM presents with signs and symptoms typical of meningitis, including fever, headache and neck stiffness. The present study reported the case of a female immunocompetent patient who presented visual blurring in both eyes and bilateral papilledema for ~1 month. Following hospital admission, the patient was diagnosed with optic nerve inflammation and was treated with intravenous methylprednisolone and oral prednisone. However, the initial symptoms failed to improve and the patient developed a headache. The microscopic examination and India ink test performed using the cerebrospinal fluid of the patient showed the presence of Cryptococcus neoformans. Following combined treatment with amphotericin B and fluconazole, the patient made a full recovery with total resolution of the initial symptoms. This case demonstrates that CM in immunocompetent patients may initially include eye symptoms, which may result in a delayed diagnosis of CM.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li J, Wang P, Ye L, Wang Y, Zhang X and Yu S: Cryptococcal meningitis initially presenting with eye symptoms in an immunocompetent patient: A case report. Exp Ther Med 12: 1119-1124, 2016
APA
Li, J., Wang, P., Ye, L., Wang, Y., Zhang, X., & Yu, S. (2016). Cryptococcal meningitis initially presenting with eye symptoms in an immunocompetent patient: A case report. Experimental and Therapeutic Medicine, 12, 1119-1124. https://doi.org/10.3892/etm.2016.3440
MLA
Li, J., Wang, P., Ye, L., Wang, Y., Zhang, X., Yu, S."Cryptococcal meningitis initially presenting with eye symptoms in an immunocompetent patient: A case report". Experimental and Therapeutic Medicine 12.2 (2016): 1119-1124.
Chicago
Li, J., Wang, P., Ye, L., Wang, Y., Zhang, X., Yu, S."Cryptococcal meningitis initially presenting with eye symptoms in an immunocompetent patient: A case report". Experimental and Therapeutic Medicine 12, no. 2 (2016): 1119-1124. https://doi.org/10.3892/etm.2016.3440