Instrumental evaluation of anti‑aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin

Hahn,Hyung Jin; Jung,Ho Jung; Schrammek‑Drusios,Med Christine; Lee,Sung Nae; Kim,Ji‑Hyun; Kwon,Seung Bin; An,In‑Sook; An,Sungkwan; Ahn,Kyu Joong

doi:10.3892/etm.2016.3447

August-2016 Volume 12 Issue 2

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August-2016 Volume 12 Issue 2

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Article

Instrumental evaluation of anti‑aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin

Authors:
- Hyung Jin Hahn
- Ho Jung Jung
- Med Christine Schrammek‑Drusios
- Sung Nae Lee
- Ji‑Hyun Kim
- Seung Bin Kwon
- In‑Sook An
- Sungkwan An
- Kyu Joong Ahn
View Affiliations / Copyright

Affiliations: Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Gyeonggi 116‑118, Republic of Korea, Department of Dermatology, Konkuk University School of Medicine, Seoul 143‑701, Republic of Korea, Dr. Med Christine Schrammek Kosmetik GmbH and Co. KG., 45127 Essen, Germany, Department of Cosmetology, Kyung‑In Women's University, Incheon 110‑810, Republic of Korea, GeneCellPharm Incorporated, Cheongju-si, Chungcheongbuk-do 363-951, Republic of Korea, Department of Biological Engineering, Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul 143‑701, Republic of Korea
Pages: 1171-1176
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Published online on: June 9, 2016

https://doi.org/10.3892/etm.2016.3447
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Abstract

Anti-aging cosmetics are widely used for improving signs of aged skin such as skin wrinkles, decreased elasticity, low dermal density and yellow skin tone. The present study evaluated the effects of cosmetic formulations, eye cream and facial cream, containing palmitoyl peptides, Silybum marianum (S. marianum) seed oil, vitamin E and other functional ingredients on the improvement of facial wrinkles, elasticity, dermal density and skin tone after 4 weeks period of application on aged human skin. Healthy volunteers (n=20) with aged skin were recruited to apply the test materials facially twice per day for 4 weeks. Skin wrinkles, elasticity, dermal density and skin tone were measured instrumentally for assessing the improvement of skin aging. All the measurements were conducted prior to the application of test materials and at 2 and 4 weeks of treatment. Crow's feet wrinkles were decreased 5.97% after 2 weeks of test material application and 14.07% after 4 weeks of application in comparison of pre‑application. Skin elasticity was increased 6.81% after 2 weeks and 8.79% after 4 weeks. Dermal density was increased 16.74% after 2 weeks and 27.63% after 4 weeks. With the L* value indicating skin brightness and the a* value indicating erythema (redness), the results showed that brightness was increased 1.70% after 2 weeks and 2.14% after 4 weeks, and erythema was decreased 10.45% after 2 weeks and 22.39% after 4 weeks. Hence, the test materials appear to exert some degree of anti‑aging effects on aged human skin. There were no abnormal skin responses from the participants during the trial period. We conclude that the facial and eye cream containing palmitoyl peptides and S. marianum seed oil, vitamin E and other ingredients have effects on the improvement of facial wrinkles, elasticity, dermal density and skin tone.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Instrumental evaluation of anti‑aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin

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