High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome

Lee,Sun‑Young; Kim,Jong‑Hyun; Cho,Dong‑Hyu

doi:10.3892/etm.2016.3458

September-2016 Volume 12 Issue 3

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September-2016 Volume 12 Issue 3

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Article Open Access

High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome

Authors:
- Sun‑Young Lee
- Jong‑Hyun Kim
- Dong‑Hyu Cho
View Affiliations / Copyright

Affiliations: Department of Radiation Oncology, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeollabuk‑do 561‑712, Republic of Korea, Institute of Clinical Medicine of Chonbuk National University‑Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Jeollabuk‑do 561‑712, Republic of Korea

Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1435-1439
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Published online on: June 15, 2016

https://doi.org/10.3892/etm.2016.3458
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Abstract

Paraneoplastic autoimmune multiorgan syndrome (PAMS), also known as paraneoplasic pemphigus, involves the skin, internal organs and mucosa. PAMS-associated mortality may occur as a result of autoantibody formation against internal tumors and their infiltration into organs other than the skin lesions that characterize PAMS. The most common symptoms of PAMS include pain associated with continuous oral ulceration and resistance to pharmacological treatment. The present study reports the case of a 42-year-old female patient who was admitted with an 8‑month history of erosive skin lesions within the trunk region, oral mucosa and vaginal mucosa. The patient was diagnosed with PAMS based on computed tomography scans and histological analyses of the lesions. The lymphoid hyperplasia in the retroperitoneum and lesions in the vaginal mucosa and trunk area were improved following pharmacological treatment and resection of the lymph node showing hyperplasia. However, the oral lesion was treated with intraluminal brachytherapy due to its resistance to long‑term pharmacological treatment. The majority of the lesions were improved following treatment, in the absence of any severe side effects. In addition, neither worsening nor progression of the oral lesion was observed during the 4-year follow-up period.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome

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