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Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms

  • Authors:
    • Chengyu Gu
    • Ying Zhang
    • Fuquan Wei
    • Yougen Cheng
    • Yulin Cao
    • Hongtao Hou
  • View Affiliations / Copyright

    Affiliations: Department of Geriatric, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, P.R. China
    Copyright: © Gu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1450-1454
    |
    Published online on: June 17, 2016
       https://doi.org/10.3892/etm.2016.3469
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Abstract

Magnetic resonance imaging (MRI) with diffusion-tensor imaging (DTI) together with a white matter fiber tracking (FT) technique was used to assess different brain white matter structures and functionalities in schizophrenic patients with typical first negative symptoms. In total, 30 schizophrenic patients with typical first negative symptoms, comprising an observation group were paired 1:1 according to gender, age, right‑handedness, and education, with 30 healthy individuals in a control group. Individuals in each group underwent routine MRI and DTI examination of the brain, and diffusion-tensor tractography (DTT) data were obtained through whole brain analysis based on voxel and tractography. The results were expressed by fractional anisotropy (FA) values. The schizophrenic patients were evaluated using a positive and negative symptom scale (PANSS) as well as a Global Assessment Scale (GAS). The results of the study showed that routine MRIs identified no differences between the two groups. However, compared with the control group, the FA values obtained by DTT from the deep left prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and part of the corpus callosum were significantly lower in the observation group (P<0.05). The PANSS positive scale value in the observation group averaged 7.7±1.5, and the negative scale averaged 46.6±5.9, while the general psychopathology scale averaged 65.4±10.3, and GAS averaged 53.8±19.2. The Pearson statistical analysis, the left deep prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and the FA value of part of the corpus callosum in the observation group was negatively correlated with the negative scale (P<0.05), and positively correlated with GAS (P<0.05). In conclusion, a decrease in the FA values of the left deep prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and part of the corpus callosum may be associated with schizophrenia with typical first negative symptoms and the application of MRI DTI-FT can improve diagnostic accuracy.
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Copy and paste a formatted citation
Spandidos Publications style
Gu C, Zhang Y, Wei F, Cheng Y, Cao Y and Hou H: Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms. Exp Ther Med 12: 1450-1454, 2016.
APA
Gu, C., Zhang, Y., Wei, F., Cheng, Y., Cao, Y., & Hou, H. (2016). Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms. Experimental and Therapeutic Medicine, 12, 1450-1454. https://doi.org/10.3892/etm.2016.3469
MLA
Gu, C., Zhang, Y., Wei, F., Cheng, Y., Cao, Y., Hou, H."Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms". Experimental and Therapeutic Medicine 12.3 (2016): 1450-1454.
Chicago
Gu, C., Zhang, Y., Wei, F., Cheng, Y., Cao, Y., Hou, H."Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1450-1454. https://doi.org/10.3892/etm.2016.3469
Copy and paste a formatted citation
x
Spandidos Publications style
Gu C, Zhang Y, Wei F, Cheng Y, Cao Y and Hou H: Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms. Exp Ther Med 12: 1450-1454, 2016.
APA
Gu, C., Zhang, Y., Wei, F., Cheng, Y., Cao, Y., & Hou, H. (2016). Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms. Experimental and Therapeutic Medicine, 12, 1450-1454. https://doi.org/10.3892/etm.2016.3469
MLA
Gu, C., Zhang, Y., Wei, F., Cheng, Y., Cao, Y., Hou, H."Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms". Experimental and Therapeutic Medicine 12.3 (2016): 1450-1454.
Chicago
Gu, C., Zhang, Y., Wei, F., Cheng, Y., Cao, Y., Hou, H."Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1450-1454. https://doi.org/10.3892/etm.2016.3469
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