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In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model

  • Authors:
    • Xiaojun Weng
    • Hailin Yang
    • Jian Xu
    • Xiaosheng Li
    • Qiande Liao
    • Jing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Joint Surgery, Hunan Provincial People's Hospital, Changsha, Hunan 410005, P.R. China, Powder Metallurgy Research Institute, Central South University, Changsha, Hunan 410078, P.R. China, Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China
    Copyright: © Weng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1323-1330
    |
    Published online on: June 23, 2016
       https://doi.org/10.3892/etm.2016.3472
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Abstract

The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X‑ray films, scanning electron microscopy (SEM) of the implant interface, energy‑dispersive spectroscopy (EDS) analysis of the implant surface, pulling‑out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti‑25Nb specimens with different porosities at different time points observed using X‑ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight‑week point postoperatively. The pulling‑out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.
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1 

Brånemark PI, Adell R, Breine U, Hansson BO, Lindström J and Ohlsson A: Intra-osseous anchorage of dental prostheses. I. Experimental studies. Scand J Plast Reconstr Surg. 3:81–100. 1969. View Article : Google Scholar : PubMed/NCBI

2 

Zarb GA and Schmitt A: Implant prosthodontic treatment options for the edentulous patient. J Oral Rehabil. 22:661–671. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Faghihi S, Zhilyaev AP, Szpunar JA, Azari F, Vali H and Tabrizian M: Nanostructuring of a titanium material by high-pressure torsion improves pre-osteoblast attachment. Adv Mater. 19:1069–1073. 2007. View Article : Google Scholar

4 

Rupp F, Scheideler L, Olshanska N, de Wild M, Wieland M and Geis-Gerstorfer J: Enhancing surface free energy and hydrophilicity through chemical modifi cation of microstructured titanium implant surfaces. J Biomed Mater Res A. 76:323–334. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Vora A, Kudrna JC, Harder VS and Mazahery B: Early failure of a proximally cemented, distally uncemented total hip arthroplasty. J Arthroplasty. 18:889–896. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Song Y, Beaupre G and Goodman SB: Osseointegration of total hip arthroplasties: Studies in humans and animals. J Long Term Eff Med Implants. 9:77–112. 1999.PubMed/NCBI

7 

LaPorte DM, Mont MA and Hungerford DS: Proximally porous-coated ingrowth prostheses: Limits of use. Orthopedics. 22:1154–1160. 1999.PubMed/NCBI

8 

Kujala S, Ryhanen J, Danilov A and Tuukkanen J: Effect of porosity on the osteointegration and bone ingrowth of a weight-bearing nickel-titanium bone graft substitute. Biomaterials. 24:4691–4697. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Li XK, Yuan CF, Wang JL, Zhang YQ, Zhang ZY and Guo Z: The treatment effect of porous titanium alloy rod on the early stage talar osteonecrosis of sheep. PLoS One. 8:e584592013. View Article : Google Scholar : PubMed/NCBI

10 

Wen CE, Yamada Y, Shimojima K, Hosokawa H and Mabuchi M: Novel titanium foam for bone tissue engineering. J Mater Res. 17:2633–2639. 2002. View Article : Google Scholar

11 

Wapner KL: Implications of metallic corrosion in total knee arthroplasty. Clin Orthop Relat Res. 271:12–20. 1991.PubMed/NCBI

12 

Long M and Rack HJ: Titanium alloys in total joint replacement-a materials science perspective. Biomaterials. 19:1621–1639. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Xu J, Weng XJ, Wang X, Huang JZ, Zhang C, Muhammad H, Ma X and Liao QD: Potential use of porous titanium-niobium alloy in orthopedic implants: Preparation and experimental study of its biocompatibility in vitro. PLoS One. 8:e792892013. View Article : Google Scholar : PubMed/NCBI

14 

Good V, Ries M, Barrack RL, Widding K, Hunter G and Heuer D: Reduced wear with oxidized zirconium femoral heads. J Bone Joint Surg Am. 85:105–110. 2003.PubMed/NCBI

15 

Ryan GE, Pandit AS and Apatsidis DP: Porous titanium scaffolds fabricated using a rapid prototyping and powder metallurgy technique. Biomaterials. 29:3625–3635. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Li C and Zhu Z: Dynamic Young's modulus of open-porosity titanium measured by the electromagnetic acoustic resonance method. J Porous Mater. 13:21–26. 2006. View Article : Google Scholar

17 

Kröger H, Venesmaa P, Jurvelin J, Miettinen H, Suomalainen O and Alhava E: Bone density at the proximal femur after total hip arthroplasty. Clin Orthop Relat Res. 66–74. 1998.

18 

Wang X, Li Y, Hodgson PD and Wen C: Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering. Tissue Eng Part A. 16:309–316. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Cornell CN and Lane JM: Current understanding of osteoconduction in bone regeneration. Clin Orthop Relat Res. (355 Suppl): S267–S273. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Tisdel CL, Goldberg VM, Parr JA, Bensusan JS, Staikoff LS and Stevenson S: The influence of a hydroxyapatite and tricalcium-phosphate coating on bone growth into titanium fiber-metal implants. J Bone Joint Surg Am. 76:159–171. 1994.PubMed/NCBI

21 

van Eeden SP and Ripamonti U: Bone differentiation in porous hydroxyapatite in baboons is regulated by the geometry of the substratum: Implications for reconstructive craniofacial surgery. Plast Reconstr Surg. 93:959–966. 1994. View Article : Google Scholar : PubMed/NCBI

22 

Nugroho AW, Leadbeater G and Davies IJ: Processing of a porous titanium alloy from elemental powders using a solid state isothermal foaming technique. J Mater Sci Mater Med. 21:3103–3107. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Baril E, Lefebvre LP and Hacking SA: Direct visualization and quantification of bone growth into porous titanium implants using micro computed tomography. J Mater Sci Mater Med. 22:1321–1332. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Vasconcellos LM, Leite DO, Oliveira FN, Carvalho YR and Cairo CA: Evaluation of bone ingrowth into porous titanium implant: Histomorphometric analysis in rabbits. Braz Oral Res. 24:399–405. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Faria PE, Carvalho AL, Felipucci DN, Wen C, Sennerby L and Salata LA: Bone formation following implantation of titanium sponge rods into humeral osteotomies in dogs: A histological and histometrical study. Clin Implant Dent Relat Res. 12:72–79. 2010. View Article : Google Scholar : PubMed/NCBI

26 

de Vasconcellos LM, Oliveira FN, Leite Dde O, de Vasconcellos LG, do Prado RF, Ramos CJ, Graça ML, Cairo CA and Carvalho YR: Novel production method of porous surface Ti samples for biomedical application. J Mater Sci Mater Med. 23:357–364. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Allori AC, Sailon AM, Pan JH and Warren SM: Biological basis of bone formation, remodeling, and repair-part III: Biomechanical forces. Tissue Eng Part B Rev. 14:285–293. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Ryan G, Pandit A and Apatsidis DP: Fabrication methods of porous metals for use in orthopaedic applications. Biomaterials. 27:2651–2670. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Simank HG, Stuber M, Frahm R, Helbig L, van Lenthe H and Müller R: The influence of surface coatings of dicalcium phosphate (DCPD) and growth and differentiation factor-5 (GDF-5) on the stability of titanium implants in vivo. Biomaterials. 27:3988–3994. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Chen D, Bertollo N, Lau A, Taki N, Nishino T, Mishima H, Kawamura H and Walsh WR: Osseointegration of porous titanium implants with and without electrochemically deposited DCPD coating in an ovine model. J Orthop Surg Res. 6:562011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Weng X, Yang H, Xu J, Li X, Liao Q and Wang J: In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model. Exp Ther Med 12: 1323-1330, 2016.
APA
Weng, X., Yang, H., Xu, J., Li, X., Liao, Q., & Wang, J. (2016). In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model. Experimental and Therapeutic Medicine, 12, 1323-1330. https://doi.org/10.3892/etm.2016.3472
MLA
Weng, X., Yang, H., Xu, J., Li, X., Liao, Q., Wang, J."In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model". Experimental and Therapeutic Medicine 12.3 (2016): 1323-1330.
Chicago
Weng, X., Yang, H., Xu, J., Li, X., Liao, Q., Wang, J."In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1323-1330. https://doi.org/10.3892/etm.2016.3472
Copy and paste a formatted citation
x
Spandidos Publications style
Weng X, Yang H, Xu J, Li X, Liao Q and Wang J: In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model. Exp Ther Med 12: 1323-1330, 2016.
APA
Weng, X., Yang, H., Xu, J., Li, X., Liao, Q., & Wang, J. (2016). In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model. Experimental and Therapeutic Medicine, 12, 1323-1330. https://doi.org/10.3892/etm.2016.3472
MLA
Weng, X., Yang, H., Xu, J., Li, X., Liao, Q., Wang, J."In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model". Experimental and Therapeutic Medicine 12.3 (2016): 1323-1330.
Chicago
Weng, X., Yang, H., Xu, J., Li, X., Liao, Q., Wang, J."In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1323-1330. https://doi.org/10.3892/etm.2016.3472
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