Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

3D-DIR for early differential diagnostic and prognostic evaluation of NMO

  • Authors:
    • Yanbing Wang
    • Hong Yan
    • Qixing Ding
    • Cunhua Mao
    • Yelong Shen
    • Guangbin Wang
  • View Affiliations / Copyright

    Affiliations: Shandong Medical Imaging Research Institute, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Radiology, Rizhao People's Hospital, Rizhao, Shandong 276826, P.R. China, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250012, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1464-1468
    |
    Published online on: June 23, 2016
       https://doi.org/10.3892/etm.2016.3474
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Neuromyelitis optica (NMO) is an acute or subacute lesion of demyelinating disease involving the optic nerve and spinal cord, and imaging techniques and their effects have been the focus of investigations. The aim of the present study was to examine the value of three-dimensional double inversion recovery (3D-DIR) in the early differential diagnostic and prognostic evaluation of NMO. Forty-eight patients with suspicious NMO were included into the study and underwent a combination of serum NMO-IgG quantitative detection and 3D-DIR examination. Forty cases (83.3%) of the suspicious cases were confirmed with NMO. The average time from onset to definite diagnosis was 3.5±0.6 days. The brain showed high T2W and fluid‑attenuated inversion recovery (FLAIR) signals, involving 5.8±1.2 sites on average, distributed in the peripheral lateral ventricle, medulla, cerebral white matter, the third ventricle, peripheral aqueduct of sylvius, pons and dience­phalon. The average T2W signal strength was 2.73±0.12. The signal intensity of DIR was significantly higher than that of T2W and FLAIR, and the difference was statistically significant. The optic nerve and chiasma showed a high FLAIR signal, with an average signal intensity of 2.13±0.14. The spinal cord showed swelling, necrosis and cavity lesion, involving the gray and white matter of the central site, transversely, with an average lesion length of 4.7±0.6 centrum. The relative signal intensity of DIR was significantly higher than that of T2W and FLAIR. Following treatment, the signal intensity of the brain, optic nerve, optic chiasma and spinal cord decreased significantly (P<0.05). In conclusion, 3D-DIR has great application value in the early differential diagnostic and prognostic evaluation of NMO.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Juryńczyk M, Craner M and Palace J: Overlapping CNS inflammatory diseases: differentiating features of NMO and MS. J Neurol Neurosurg Psychiatry. 86:20–25. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Mealy MA, Wingerchuk DM, Greenberg BM and Levy M: Epidemiology of neuromyelitis optica in the United States: a multicenter analysis. Arch Neurol. 69:1176–1180. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Simon B, Schmidt S, Lukas C, Gieseke J, Träber F, Knol DL, Willinek WA, Geurts JJ, Schild HH, Barkhof F, et al: Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla. Eur Radiol. 20:1675–1683. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Riederer I, Karampinos DC, Settles M, Preibisch C, Bauer JS, Kleine JF, Mühlau M and Zimmer C: Double inversion recovery sequence of the cervical spinal cord in multiple sclerosis and related inflammatory diseases. AJNR Am J Neuroradiol. 36:219–225. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Morimoto E, Kanagaki M, Okada T, Yamamoto A, Mori N, Matsumoto R, Ikeda A, Mikuni N, Kunieda T, Paul D, et al: Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator of seizure focus laterality in temporal lobe epilepsy: comparison of double inversion recovery, FLAIR and T2W MR imaging. Eur Radiol. 23:3–11. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Vural G, Keklikoğlu HD, Temel Ş, Deniz O and Ercan K: Comparison of double inversion recovery and conventional magnetic resonance brain imaging in patients with multiple sclerosis and relations with disease disability. Neuroradiol J. 26:133–142. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, et al: International Panel for NMO Diagnosis: International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 85:177–189. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Khanna S, Sharma A, Huecker J, Gordon M, Naismith RT and Van Stavern GP: Magnetic resonance imaging of optic neuritis in patients with neuromyelitis optica versus multiple sclerosis. J Neuroophthalmol. 32:216–220. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Tackley G, Kuker W and Palace J: Tackle yG, Kuker W and Palace J: Magnetic resonance imaging in neuromyelitis optica. Mult Scler. 20:1153–1164. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Schneider E, Zimmermann H, Oberwahrenbrock T, Kaufhold F, Kadas EM, Petzold A, Bilger F, Borisow N, Jarius S, Wildemann B, et al: Optical coherence tomography reveals distinct patterns of retinal damage in neuromyelitis optica and multiple sclerosis. PLoS One. 8:e661512013. View Article : Google Scholar : PubMed/NCBI

11 

Sinnecker T, Dörr J, Pfueller CF, Harms L, Ruprecht K, Jarius S, Brück W, Niendorf T, Wuerfel J and Paul F: Distinct lesion morphology at 7-T MRI differentiates neuromyelitis optica from multiple sclerosis. Neurology. 79:708–714. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Iyer A, Elsone L, Appleton R and Jacob A: A review of the current literature and a guide to the early diagnosis of autoimmune disorders associated with neuromyelitis optica. Autoimmunity. 47:154–161. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Kolber P, Montag S, Fleischer V, Luessi F, Wilting J, Gawehn J, Gröger A and Zipp F: Identification of cortical lesions using DIR and FLAIR in early stages of multiple sclerosis. J Neurol. 262:1473–1482. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Coebergh JA, Roosendaal SD, Polman CH, Geurts JJ and van Woerkom TC: Acute severe memory impairment as a presenting symptom of multiple sclerosis: a clinical case study with 3D double inversion recovery MR imaging. Mult Scler. 16:1521–1524. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Calabrese M and De Stefano N: Cortical lesion counts by double inversion recovery should be part of the MRI monitoring process for all MS patients: yes. Mult Scler. 20:537–538. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Li Q, Zhang Q, Sun H, Zhang Y and Bai R: Double inversion recovery magnetic resonance imaging at 3 T: diagnostic value in hippocampal sclerosis. J Comput Assist Tomogr. 35:290–293. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Seewann A, Kooi EJ, Roosendaal SD, Pouwels PJ, Wattjes MP, van der Valk P, Barkhof F, Polman CH and Geurts JJ: Postmortem verification of MS cortical lesion detection with 3D DIR. Neurology. 78:302–308. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Pittock SJ, Weinshenker BG, Lucchinetti CF, Wingerchuk DM, Corboy JR and Lennon VA: Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression. Arch Neurol. 63:964–968. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Ito S, Mori M, Makino T, Hayakawa S and Kuwabara S: ‘Cloud-like enhancement’ is a magnetic resonance imaging abnormality specific to neuromyelitis optica. Ann Neurol. 66:425–428. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Hodel J, Outteryck O, Bocher AL, Zéphir H, Lambert O, Benadjaoud MA, Chechin D, Pruvo JP, Vermersch P and Leclerc X: Comparison of 3D double inversion recovery and 2D STIR FLAIR MR sequences for the imaging of optic neuritis: pilot study. Eur Radiol. 24:3069–3075. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Yan H, Ding Q, Mao C, Shen Y and Wang G: 3D-DIR for early differential diagnostic and prognostic evaluation of NMO. Exp Ther Med 12: 1464-1468, 2016.
APA
Wang, Y., Yan, H., Ding, Q., Mao, C., Shen, Y., & Wang, G. (2016). 3D-DIR for early differential diagnostic and prognostic evaluation of NMO. Experimental and Therapeutic Medicine, 12, 1464-1468. https://doi.org/10.3892/etm.2016.3474
MLA
Wang, Y., Yan, H., Ding, Q., Mao, C., Shen, Y., Wang, G."3D-DIR for early differential diagnostic and prognostic evaluation of NMO". Experimental and Therapeutic Medicine 12.3 (2016): 1464-1468.
Chicago
Wang, Y., Yan, H., Ding, Q., Mao, C., Shen, Y., Wang, G."3D-DIR for early differential diagnostic and prognostic evaluation of NMO". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1464-1468. https://doi.org/10.3892/etm.2016.3474
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Yan H, Ding Q, Mao C, Shen Y and Wang G: 3D-DIR for early differential diagnostic and prognostic evaluation of NMO. Exp Ther Med 12: 1464-1468, 2016.
APA
Wang, Y., Yan, H., Ding, Q., Mao, C., Shen, Y., & Wang, G. (2016). 3D-DIR for early differential diagnostic and prognostic evaluation of NMO. Experimental and Therapeutic Medicine, 12, 1464-1468. https://doi.org/10.3892/etm.2016.3474
MLA
Wang, Y., Yan, H., Ding, Q., Mao, C., Shen, Y., Wang, G."3D-DIR for early differential diagnostic and prognostic evaluation of NMO". Experimental and Therapeutic Medicine 12.3 (2016): 1464-1468.
Chicago
Wang, Y., Yan, H., Ding, Q., Mao, C., Shen, Y., Wang, G."3D-DIR for early differential diagnostic and prognostic evaluation of NMO". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1464-1468. https://doi.org/10.3892/etm.2016.3474
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team