Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats

  • Authors:
    • Nina V. Sayapina
    • Alexander A. Sergievich
    • Vladimir L. Kuznetsov
    • Vladimir V. Chaika
    • Irina G. Lisitskaya
    • Pavel P. Khoroshikh
    • Tatyana A. Batalova
    • Kostas Tsarouhas
    • Demetrios Spandidos
    • Aristidis M. Tsatsakis
    • Concettina Fenga
    • Kirill S. Golokhvast
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Amur State Medical Academy, 675000 Blagoveshchensk, Russia, Scientific Educational Center of Nanotechnology, Far Eastern Federal University, 690950 Vladivostok, Russia, Group of Surface Compounds Synthesis, Boreskov Institute of Catalysis SB RAS, 630090 Novosibirsk, Russia, Technical Institute, North‑Eastern Federal University, 678962 Nerungri, Russia, Cardiology Department, University Hospital of Larissa, 41110 Thessaly, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 74100 Heraklion, Greece, Department of Occupational Medicine, University of Messina, 98166 Messina, Italy
    Copyright: © Sayapina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1311-1318
    |
    Published online on: July 1, 2016
       https://doi.org/10.3892/etm.2016.3495
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Studies of the neurobehavioral effects of carbon nanomaterials, particularly those of multi‑walled carbon nanotubes (MWCNTs), have concentrated on cognitive effects, but data are scarce. The aim of this study was to assess the influence of MWCNTs on a number of higher nervous system functions of Wistar rats. For a period of 10 days, two experimental groups were fed with MWCNTs of different diameters (MWCNT-1 group, 8‑10 nm; MWCNT-2 group, 18‑20 nm) once a day at a dosage of 500 mg/kg. In the open‑field test, reductions of integral indications of researching activity were observed for the two MWCNT-treated groups, with a parallel significant (P<0.01) increase in stress levels for these groups compared with the untreated control group. In the elevated plus‑maze test, integral indices of researching activity in the MWCNT-1 and MWCNT-2 groups reduced by day 10 by 51 and 62%, respectively, while rat stress levels remained relatively unchanged. In the universal problem solving box test, reductions in motivation and energy indices of researching activity were observed in the two experimental groups. Searching activity in the MWCNT‑1 group by day 3 was reduced by 50% (P<0.01) and in the MWCNT‑2 group the relevant reduction reached 11.2%. By day 10, the reduction compared with controls, was 64% (P<0.01) and 58% (P<0.01) for the MWCNT‑1 and MWCNT‑2 groups, respectively. In conclusion, a series of specific tests demonstrated that MWCNT‑treated rats experienced a significant reduction of some of their cognitive abilities, a disturbing and worrying finding, taking into consideration the continuing and accelerating use of carbon nanotubes in medicine and science.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Popp L and Segatori L: Differential autophagic responses to nano-sized materials. Curr Opin Biotechnol. 36:129–136. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Wang CY, Zhang YY, Wang CM and Tan VB: Buckling of carbon nanotubes: A literature survey. J Nanosci Nanotechnol. 7:4221–4247. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Gao J, Zhang X, Yu M, Ren G and Yang Z: Cognitive deficits induced by multi-walled carbon nanotubes via the autophagic pathway. Toxicology. 337:21–29. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Bottini M, Bruckner S, Nika K, Bottini N, Bellucci S, Magrini A, Bergamaschi A and Mustelin T: Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol Lett. 160:121–126. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Møller P, Jensen DM, Christophersen DV, Kermanizadeh A, Jacobsen NR, Hemmingsen JG, Danielsen PH, Karottki DG, Roursgaard M, Cao Y, et al: Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals. Environ Mol Mutagen. 56:97–110. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Elgrabli D, Dachraoui W, Ménard-Moyon C, Liu XJ, Bégin D, Bégin-Colin S, Bianco A, Gazeau F and Alloyeau D: Carbon nanotube degradation in macrophages: Live nanoscale monitoring and understanding of biological pathway. ACS Nano. 9:10113–10124. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Dal Bosco L, Weber GE, Parfitt GM, Paese K, Gonçalves CO, Serodre TM, Furtado CA, Santos AP, Monserrat JM and Barros DM: PEGylated carbon nanotubes impair retrieval of contextual fear memory and alter oxidative stress parameters in the rat hippocampus. Biomed Res Int. 2015:1041352015. View Article : Google Scholar : PubMed/NCBI

8 

Liu X, Zhang Y, Li J, Wang D, Wu Y, Li Y, Lu Z, Yu SC, Li R and Yang X: Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid. Int J Nanomedicine. 9:823–839. 2014.PubMed/NCBI

9 

Ivani S, Karimi I, Tabatabaei SR and Syedmoradi L: Effects of prenatal exposure to single-wall carbon nanotubes on reproductive performance and neurodevelopment in mice. Toxicol Ind Health. 07482337145553882014.

10 

Fenoglio I, Aldieri E, Gazzano E, Cesano F, Colonna M, Scarano D, Mazzucco G, Attanasio A, Yakoub Y, Lison D and Fubini B: Thickness of multiwalled carbon nanotubes affects their lung toxicity. Chem Res Toxicol. 25:74–82. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, Ishihara T, Yamashita K, Yoshikawa Y, Yasui H, et al: Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proc Natl Acad Sci USA. 108:E1330–E1338. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Sayapina NV, Batalova TA, Chaika VV, Kuznetsov VL, Sergievich AA, Kolosov VP, Perel'man YM and Golokhvast KS: Multi-walled carbon nanotubes increase anxiety levels in rats and reduce exploratory activity in the open field test. Dokl Biol Sci. 464:223–225. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Sandini TM, Udo MS, Reis-Silva TM, Sanches D, Bernardi MM, Flório JC and Spinosa Hde S: Prenatal exposure to integerrimine N-oxide enriched butanolic residue from Senecio brasiliensis affects behavior and striatal neurotransmitter levels of rats in adulthood. Int J Dev Neurosci. 47:157–164. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Menachem A, Chapman J, Deri Y, Pick CG and Katzav A: Immunoglobulin-mediated neuro-cognitive impairment: New data and a comprehensive review. Clin Rev Allergy Immunol. 45:248–255. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Grigor'ev NR, Batalova TA, Kirichenko EF, Sergievich AA and Cherbikova GE: Typological features in the behavior of rats. Neurosci Behav Physiol. 38:597–603. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Buslovich Slu, Kotelenets AI and Fridliand RM: An integral method of evaluating the open-field behavior of white rats. Zh Vyssh Nerv Deiat Im I P Pavlova. 39:168–171. 1989.(In Russian). PubMed/NCBI

17 

Pellow S, Chopin P, File SE and Briley M: Validation of open: Closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods. 14:149–167. 1985. View Article : Google Scholar : PubMed/NCBI

18 

Pellow S and File SE: Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat. Pharmacol Biochem Behav. 24:525–529. 1986. View Article : Google Scholar : PubMed/NCBI

19 

Grigor'ev NR: A method for the quantitative evaluation of search activity and refusal to search in an experiment with rats. Zh Vyssh Nerv Deiat Im I P Pavlova. 46:400–405. 1996.(In Russian). PubMed/NCBI

20 

Golokhvast K, Sergievich A and Grigoriev N: Geophagy (rock eating), experimental stress and cognitive idiosyncrasy. Asian Pac J Trop Biomed. 4:362–366. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Bianco A, Kostarelos K and Prato M: Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol. 9:674–679. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Mudie DM, Amidon GL and Amidon GE: Physiological parameters for oral delivery and in vitro testing. Mol Pharm. 7:1388–1405. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Win-Shwe TT and Fujimaki H: Nanoparticles and neurotoxicity. Int J Mol Sci. 12:6267–6280. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Rosenblat JD, Brietzke E, Mansur RB, Maruschak NA, Lee Y and McIntyre RS: Inflammation as a neurobiological substrate of cognitive impairment in bipolar disorder: Evidence, pathophysiology and treatment implications. J Affect Disord. 188:149–159. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Grigor'ev NR, Li Tingli and Shao-Iuan' L: Cognitive abilities of rats in behavior of the active avoidance in age differences. Zh Vyssh Nerv Deiat Im I P Pavlova. 64:314–323. 2014.(In Russian). PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sayapina NV, Sergievich AA, Kuznetsov VL, Chaika VV, Lisitskaya IG, Khoroshikh PP, Batalova TA, Tsarouhas K, Spandidos D, Tsatsakis AM, Tsatsakis AM, et al: Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats. Exp Ther Med 12: 1311-1318, 2016.
APA
Sayapina, N.V., Sergievich, A.A., Kuznetsov, V.L., Chaika, V.V., Lisitskaya, I.G., Khoroshikh, P.P. ... Golokhvast, K.S. (2016). Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats. Experimental and Therapeutic Medicine, 12, 1311-1318. https://doi.org/10.3892/etm.2016.3495
MLA
Sayapina, N. V., Sergievich, A. A., Kuznetsov, V. L., Chaika, V. V., Lisitskaya, I. G., Khoroshikh, P. P., Batalova, T. A., Tsarouhas, K., Spandidos, D., Tsatsakis, A. M., Fenga, C., Golokhvast, K. S."Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats". Experimental and Therapeutic Medicine 12.3 (2016): 1311-1318.
Chicago
Sayapina, N. V., Sergievich, A. A., Kuznetsov, V. L., Chaika, V. V., Lisitskaya, I. G., Khoroshikh, P. P., Batalova, T. A., Tsarouhas, K., Spandidos, D., Tsatsakis, A. M., Fenga, C., Golokhvast, K. S."Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1311-1318. https://doi.org/10.3892/etm.2016.3495
Copy and paste a formatted citation
x
Spandidos Publications style
Sayapina NV, Sergievich AA, Kuznetsov VL, Chaika VV, Lisitskaya IG, Khoroshikh PP, Batalova TA, Tsarouhas K, Spandidos D, Tsatsakis AM, Tsatsakis AM, et al: Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats. Exp Ther Med 12: 1311-1318, 2016.
APA
Sayapina, N.V., Sergievich, A.A., Kuznetsov, V.L., Chaika, V.V., Lisitskaya, I.G., Khoroshikh, P.P. ... Golokhvast, K.S. (2016). Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats. Experimental and Therapeutic Medicine, 12, 1311-1318. https://doi.org/10.3892/etm.2016.3495
MLA
Sayapina, N. V., Sergievich, A. A., Kuznetsov, V. L., Chaika, V. V., Lisitskaya, I. G., Khoroshikh, P. P., Batalova, T. A., Tsarouhas, K., Spandidos, D., Tsatsakis, A. M., Fenga, C., Golokhvast, K. S."Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats". Experimental and Therapeutic Medicine 12.3 (2016): 1311-1318.
Chicago
Sayapina, N. V., Sergievich, A. A., Kuznetsov, V. L., Chaika, V. V., Lisitskaya, I. G., Khoroshikh, P. P., Batalova, T. A., Tsarouhas, K., Spandidos, D., Tsatsakis, A. M., Fenga, C., Golokhvast, K. S."Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1311-1318. https://doi.org/10.3892/etm.2016.3495
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team