Open Access

Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats

  • Authors:
    • Nina V. Sayapina
    • Alexander A. Sergievich
    • Vladimir L. Kuznetsov
    • Vladimir V. Chaika
    • Irina G. Lisitskaya
    • Pavel P. Khoroshikh
    • Tatyana A. Batalova
    • Kostas Tsarouhas
    • Demetrios Spandidos
    • Aristidis M. Tsatsakis
    • Concettina Fenga
    • Kirill S. Golokhvast
  • View Affiliations

  • Published online on: July 1, 2016     https://doi.org/10.3892/etm.2016.3495
  • Pages: 1311-1318
  • Copyright: © Sayapina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Studies of the neurobehavioral effects of carbon nanomaterials, particularly those of multi‑walled carbon nanotubes (MWCNTs), have concentrated on cognitive effects, but data are scarce. The aim of this study was to assess the influence of MWCNTs on a number of higher nervous system functions of Wistar rats. For a period of 10 days, two experimental groups were fed with MWCNTs of different diameters (MWCNT-1 group, 8‑10 nm; MWCNT-2 group, 18‑20 nm) once a day at a dosage of 500 mg/kg. In the open‑field test, reductions of integral indications of researching activity were observed for the two MWCNT-treated groups, with a parallel significant (P<0.01) increase in stress levels for these groups compared with the untreated control group. In the elevated plus‑maze test, integral indices of researching activity in the MWCNT-1 and MWCNT-2 groups reduced by day 10 by 51 and 62%, respectively, while rat stress levels remained relatively unchanged. In the universal problem solving box test, reductions in motivation and energy indices of researching activity were observed in the two experimental groups. Searching activity in the MWCNT‑1 group by day 3 was reduced by 50% (P<0.01) and in the MWCNT‑2 group the relevant reduction reached 11.2%. By day 10, the reduction compared with controls, was 64% (P<0.01) and 58% (P<0.01) for the MWCNT‑1 and MWCNT‑2 groups, respectively. In conclusion, a series of specific tests demonstrated that MWCNT‑treated rats experienced a significant reduction of some of their cognitive abilities, a disturbing and worrying finding, taking into consideration the continuing and accelerating use of carbon nanotubes in medicine and science.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Sayapina NV, Sergievich AA, Kuznetsov VL, Chaika VV, Lisitskaya IG, Khoroshikh PP, Batalova TA, Tsarouhas K, Spandidos D, Tsatsakis AM, Tsatsakis AM, et al: Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats. Exp Ther Med 12: 1311-1318, 2016
APA
Sayapina, N.V., Sergievich, A.A., Kuznetsov, V.L., Chaika, V.V., Lisitskaya, I.G., Khoroshikh, P.P. ... Golokhvast, K.S. (2016). Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats. Experimental and Therapeutic Medicine, 12, 1311-1318. https://doi.org/10.3892/etm.2016.3495
MLA
Sayapina, N. V., Sergievich, A. A., Kuznetsov, V. L., Chaika, V. V., Lisitskaya, I. G., Khoroshikh, P. P., Batalova, T. A., Tsarouhas, K., Spandidos, D., Tsatsakis, A. M., Fenga, C., Golokhvast, K. S."Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats". Experimental and Therapeutic Medicine 12.3 (2016): 1311-1318.
Chicago
Sayapina, N. V., Sergievich, A. A., Kuznetsov, V. L., Chaika, V. V., Lisitskaya, I. G., Khoroshikh, P. P., Batalova, T. A., Tsarouhas, K., Spandidos, D., Tsatsakis, A. M., Fenga, C., Golokhvast, K. S."Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1311-1318. https://doi.org/10.3892/etm.2016.3495