Analysis on distribution features and drug resistance of clinically isolated Acinetobacter baumannii

Ren,Guangming; Zhou,Min; Ding,Ning; Zhou,Ning; Li,Qingling

doi:10.3892/etm.2016.3513

September-2016 Volume 12 Issue 3

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September-2016 Volume 12 Issue 3

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Article Open Access

Analysis on distribution features and drug resistance of clinically isolated Acinetobacter baumannii

Authors:
- Guangming Ren
- Min Zhou
- Ning Ding
- Ning Zhou
- Qingling Li
View Affiliations / Copyright

Affiliations: Department of Pneumology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China

Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1715-1718
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Published online on: July 11, 2016

https://doi.org/10.3892/etm.2016.3513
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Abstract

The aim of the present study was to examine the clinical distribution and drug resistance of Acinetobacter baumannii infection, and provide evidence of clinical medication as well as the prophylaxis for the treatment of drug resistance bacteria. In total, 306 Acinetobacter baumanniis selected from routine culture were collected between January 2012 and December 2013, to analyze the distributions among clinical specimens and wards and their drug resistance state. Of the 306 Acinetobacter baumanniis, the main distribution of specimens was sputum, accounting for 77.78%. The distribution of administrative office was dominated by intensive care unit with a proportion of 40.0% in 2012, which rapidly increased to 60.9% in 2013, followed by neurosurgery, respiration medicine and orthopedics with proportions of 23, 12 and 9.0% in 2012 and 9.71, 8.74 and 3.88% in 2013, respectively. The Acinetobacter baumannii's drug resistance rate of Tazobactam and Piperacillin was increased from 68.0% in 2012 to 71.36% in 2013. At the same time, the drug resistance rate of imipenem was enhanced from 66.0% in 2012 to 72.81% in 2013. By 2013, the drug resistance rates of penbritin, ceftizoxime, cefotetan and macrodantin reached ≤100%. In conclusion, Acinetobacter baumannii mainly causes respiratory tract infection with severe drug resistance. The drug resistance of Acinetobacter baumannii was mainly manifested as multidrug resistance or even pan‑drug resistance with an obvious increasing trend of tolerance. Thus, it is necessary to prevent and treat nosocomial infection, to minimize usage of antibiotics and to standardize medical operating, to reduce the increase in persistence.

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1	Giamarellou H, Antoniadou A and Kanellakopoulou K: Acinetobacter baumannii: A universal threat to public health? Int J Antimicrob Agents. 32:106–119. 2008. View Article : Google Scholar : PubMed/NCBI
2	Mishra SK, Rijal BP and Pokhrel BM: Emerging threat of multidrug resistant bugs-Acinetobacter calcoaceticus baumannii complex and methicillin resistant Staphylococcus aureus. BMC Res Notes. 6:982013. View Article : Google Scholar : PubMed/NCBI
3	Krcmery V and Kalavsky E: Multidrug-resistant Acinetobacter baumannii. Emerg Infect Dis. 13:943–944. 2007. View Article : Google Scholar : PubMed/NCBI
4	Zhu X, Zhang M, Wang S, et al: The clinical distribution and drug-resistant analysis of baumanii's infection in the hospital. Lab Med. 27:788–790. 2012.(In Chinese).
5	Gootz TD and Marra A: Acinetobacter baumannii: An emerging multidrug-resistant threat. Expert Rev Anti Infect Ther. 6:309–325. 2008. View Article : Google Scholar : PubMed/NCBI
6	Du J and Li W: Distribution and resistance analysis of 148 Acinetobacter baumannii clinical isolates. Lab Med Clinic. 10:155–156. 2013.
7	Hsueh PR, Ko WC, Wu JJ, Lu JJ, Wang FD, Wu HY, Wu TL and Teng LJ: Consensus statement on the adherence to Clinical and Laboratory Standards Institute (CLSI) Antimicrobial Susceptibility Testing Guidelines (CLSI-2010 and CLSI-2010-update) for Enterobacteriaceae in clinical microbiology laboratories in Taiwan. J Microbiol Immunol Infect. 43:452–455. 2010. View Article : Google Scholar : PubMed/NCBI
8	Mochizuki T, Okamoto N, Yagishita T, Takuhiro K, Mashiko K, Ogawa F, Tosaka N, Kurokawa A and Yamamoto Y: Analysis of antimicrobial drug resistance of Staphylococcus aureus strains by WHONET 5: Microbiology laboratory database software. J Nippon Med Sch. 71:345–351. 2004. View Article : Google Scholar : PubMed/NCBI
9	Luo P, Dai W and Zhang L: Clinical distribution and drug resistance analysis of 1582 Acinetobacter baumannii. Chongqing Med. 40:224–228. 2011.(In Chinese).
10	Zhang Y, Jia W and Zhao Z: The clinical distribution and drug-resistant analysis of baumaniis. Chin J Nosocomiol. 21:364–366. 2011.
11	Feng D, Dong F and Xu X: The clinical distribution and drug-resistant analysis of the baumanii in PICU. J Xinxiang Med Coll. 25:591–593. 2008.(In Chinese).
12	Xu G and Long X: The diagnoses of preventive antibacterials among 570 perioperative patients. J Pract Clin Med. 12:83–84. 2008.
13	Peleg AY, Seifert H and Paterson DL: Acinetobacter baumannii: Emergence of a successful pathogen. Clin Microbiol Rev. 21:538–582. 2008. View Article : Google Scholar : PubMed/NCBI
14	Gould IM: The epidemidogy of antibiotic resistance. Int J Antimicrob Agents (Suppl 1). 32:S2–S9. 2008. View Article : Google Scholar
15	Zhu M, Sun X and Jiang R: The research of multi-drug resistant baumanii's resistance mechanism to 7 kinds of antibacterial agents. Chin J Nosocomiology. 20:2184–2188. 2010.
16	Mendes RE, Bell JM, Turnidge JD, Castanheira M and Jones RN: Emergence and widespread dissemination of OXA-23, −24/40 and −58 carbapenemases among Acinetobacter spp. in Asia-Pacific nations: Report from the SENTRY Surveillance Program. J Antimicrob Chemother. 63:55–59. 2009. View Article : Google Scholar : PubMed/NCBI
17	Lai Y, Wu J and Yang J: The monitor of clinical distribution and drug resistantances of baumanii. China Trop Med. 12:342–344. 2013.(In Chinese).

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Analysis on distribution features and drug resistance of clinically isolated Acinetobacter baumannii

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