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Article

Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats

  • Authors:
    • Qiaoer Su
    • Yifan Cheng
    • Kunlin Jin
    • Jianhua Cheng
    • Yuanshao Lin
    • Zhenzhen Lin
    • Liuqing Wang
    • Bei Shao
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
  • Pages: 1843-1848
    |
    Published online on: July 19, 2016
       https://doi.org/10.3892/etm.2016.3531
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Abstract

The present study investigated the effect of exogenous estrogen on post-stroke depression. Rats were exposed to chronic mild stress following middle cerebral artery occlusion. The occurrence of post‑stroke depression was evaluated according to the changes in preference for sucrose and performance in a forced swimming test. Estrogen therapy significantly improved these neurological symptoms, indicating that estrogen is effective in treating post‑stroke depression. Increased brain‑derived neurotrophic factor (BDNF) expression was reported in the hippocampus of rats that had been treated with estrogen for two weeks, suggesting that BDNF expression may be an important contributor to the improvement of post‑stroke depression that is observed following estrogen therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Su Q, Cheng Y, Jin K, Cheng J, Lin Y, Lin Z, Wang L and Shao B: Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats. Exp Ther Med 12: 1843-1848, 2016.
APA
Su, Q., Cheng, Y., Jin, K., Cheng, J., Lin, Y., Lin, Z. ... Shao, B. (2016). Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats. Experimental and Therapeutic Medicine, 12, 1843-1848. https://doi.org/10.3892/etm.2016.3531
MLA
Su, Q., Cheng, Y., Jin, K., Cheng, J., Lin, Y., Lin, Z., Wang, L., Shao, B."Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats". Experimental and Therapeutic Medicine 12.3 (2016): 1843-1848.
Chicago
Su, Q., Cheng, Y., Jin, K., Cheng, J., Lin, Y., Lin, Z., Wang, L., Shao, B."Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1843-1848. https://doi.org/10.3892/etm.2016.3531
Copy and paste a formatted citation
x
Spandidos Publications style
Su Q, Cheng Y, Jin K, Cheng J, Lin Y, Lin Z, Wang L and Shao B: Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats. Exp Ther Med 12: 1843-1848, 2016.
APA
Su, Q., Cheng, Y., Jin, K., Cheng, J., Lin, Y., Lin, Z. ... Shao, B. (2016). Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats. Experimental and Therapeutic Medicine, 12, 1843-1848. https://doi.org/10.3892/etm.2016.3531
MLA
Su, Q., Cheng, Y., Jin, K., Cheng, J., Lin, Y., Lin, Z., Wang, L., Shao, B."Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats". Experimental and Therapeutic Medicine 12.3 (2016): 1843-1848.
Chicago
Su, Q., Cheng, Y., Jin, K., Cheng, J., Lin, Y., Lin, Z., Wang, L., Shao, B."Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1843-1848. https://doi.org/10.3892/etm.2016.3531
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