Open Access

Association of dementia with death after ischemic stroke: A two-year prospective study

  • Authors:
    • Chang-Yue Gao
    • Yan Lian
    • Meng Zhang
    • Li-Li Zhang
    • Chuan-Qing Fang
    • Juan Deng
    • Jing Li
    • Zhi-Qiang Xu
    • Hua-Dong Zhou
    • Yan-Jiang Wang
  • View Affiliations

  • Published online on: July 22, 2016     https://doi.org/10.3892/etm.2016.3538
  • Pages: 1765-1769
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The association between dementia and the risk of death after ischemic stroke was investigated. Neurological, neuropsychological and functional assessments were evaluated in 619 patients with acute ischemic stroke. Dementia was diagnosed at admission and at three months after stroke onset. The patients were scheduled for a two-year follow‑up after the index stroke. The Kaplan-Meier survival and Cox proportional hazards regression analyses were used to estimate the cumulative proportion of survival, and the association between dementia and risk of death after stroke. In total, 146 patients (23.6%) were diagnosed with dementia after stroke. The cumulative proportion of surviving cases was 49.3% in patients with dementia after a median follow-up of 21.2±5.6 months, and 92.5% in patients without dementia. Multivariate analysis revealed that dementia (HR, 7.21; 95% CI, 3.85-13.49) was associated with death, independent of age, atrial fibrillation, previous stroke and NIH stroke scale. In conclusion, the mortality rate is increased in stroke patients with dementia. Dementia is an important risk factor for death after stroke, independent of age, atrial fibrillation, previous stroke, and the severity of the stroke.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gao C, Lian Y, Zhang M, Zhang L, Fang C, Deng J, Li J, Xu Z, Zhou H, Wang Y, Wang Y, et al: Association of dementia with death after ischemic stroke: A two-year prospective study. Exp Ther Med 12: 1765-1769, 2016
APA
Gao, C., Lian, Y., Zhang, M., Zhang, L., Fang, C., Deng, J. ... Wang, Y. (2016). Association of dementia with death after ischemic stroke: A two-year prospective study. Experimental and Therapeutic Medicine, 12, 1765-1769. https://doi.org/10.3892/etm.2016.3538
MLA
Gao, C., Lian, Y., Zhang, M., Zhang, L., Fang, C., Deng, J., Li, J., Xu, Z., Zhou, H., Wang, Y."Association of dementia with death after ischemic stroke: A two-year prospective study". Experimental and Therapeutic Medicine 12.3 (2016): 1765-1769.
Chicago
Gao, C., Lian, Y., Zhang, M., Zhang, L., Fang, C., Deng, J., Li, J., Xu, Z., Zhou, H., Wang, Y."Association of dementia with death after ischemic stroke: A two-year prospective study". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1765-1769. https://doi.org/10.3892/etm.2016.3538