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Association of dementia with death after ischemic stroke: A two-year prospective study

  • Authors:
    • Chang-Yue Gao
    • Yan Lian
    • Meng Zhang
    • Li-Li Zhang
    • Chuan-Qing Fang
    • Juan Deng
    • Jing Li
    • Zhi-Qiang Xu
    • Hua-Dong Zhou
    • Yan-Jiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, The Third Military Medical University, Chongqing 400042, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1765-1769
    |
    Published online on: July 22, 2016
       https://doi.org/10.3892/etm.2016.3538
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Abstract

The association between dementia and the risk of death after ischemic stroke was investigated. Neurological, neuropsychological and functional assessments were evaluated in 619 patients with acute ischemic stroke. Dementia was diagnosed at admission and at three months after stroke onset. The patients were scheduled for a two-year follow‑up after the index stroke. The Kaplan-Meier survival and Cox proportional hazards regression analyses were used to estimate the cumulative proportion of survival, and the association between dementia and risk of death after stroke. In total, 146 patients (23.6%) were diagnosed with dementia after stroke. The cumulative proportion of surviving cases was 49.3% in patients with dementia after a median follow-up of 21.2±5.6 months, and 92.5% in patients without dementia. Multivariate analysis revealed that dementia (HR, 7.21; 95% CI, 3.85-13.49) was associated with death, independent of age, atrial fibrillation, previous stroke and NIH stroke scale. In conclusion, the mortality rate is increased in stroke patients with dementia. Dementia is an important risk factor for death after stroke, independent of age, atrial fibrillation, previous stroke, and the severity of the stroke.
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Copy and paste a formatted citation
Spandidos Publications style
Gao C, Lian Y, Zhang M, Zhang L, Fang C, Deng J, Li J, Xu Z, Zhou H, Wang Y, Wang Y, et al: Association of dementia with death after ischemic stroke: A two-year prospective study. Exp Ther Med 12: 1765-1769, 2016.
APA
Gao, C., Lian, Y., Zhang, M., Zhang, L., Fang, C., Deng, J. ... Wang, Y. (2016). Association of dementia with death after ischemic stroke: A two-year prospective study. Experimental and Therapeutic Medicine, 12, 1765-1769. https://doi.org/10.3892/etm.2016.3538
MLA
Gao, C., Lian, Y., Zhang, M., Zhang, L., Fang, C., Deng, J., Li, J., Xu, Z., Zhou, H., Wang, Y."Association of dementia with death after ischemic stroke: A two-year prospective study". Experimental and Therapeutic Medicine 12.3 (2016): 1765-1769.
Chicago
Gao, C., Lian, Y., Zhang, M., Zhang, L., Fang, C., Deng, J., Li, J., Xu, Z., Zhou, H., Wang, Y."Association of dementia with death after ischemic stroke: A two-year prospective study". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1765-1769. https://doi.org/10.3892/etm.2016.3538
Copy and paste a formatted citation
x
Spandidos Publications style
Gao C, Lian Y, Zhang M, Zhang L, Fang C, Deng J, Li J, Xu Z, Zhou H, Wang Y, Wang Y, et al: Association of dementia with death after ischemic stroke: A two-year prospective study. Exp Ther Med 12: 1765-1769, 2016.
APA
Gao, C., Lian, Y., Zhang, M., Zhang, L., Fang, C., Deng, J. ... Wang, Y. (2016). Association of dementia with death after ischemic stroke: A two-year prospective study. Experimental and Therapeutic Medicine, 12, 1765-1769. https://doi.org/10.3892/etm.2016.3538
MLA
Gao, C., Lian, Y., Zhang, M., Zhang, L., Fang, C., Deng, J., Li, J., Xu, Z., Zhou, H., Wang, Y."Association of dementia with death after ischemic stroke: A two-year prospective study". Experimental and Therapeutic Medicine 12.3 (2016): 1765-1769.
Chicago
Gao, C., Lian, Y., Zhang, M., Zhang, L., Fang, C., Deng, J., Li, J., Xu, Z., Zhou, H., Wang, Y."Association of dementia with death after ischemic stroke: A two-year prospective study". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1765-1769. https://doi.org/10.3892/etm.2016.3538
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