Deep vein thrombosis is accurately predicted by comprehensive analysis of the levels of microRNA-96 and plasma D-dimer

Xie,Xuesheng; Liu,Changpeng; Lin,Wei; Zhan,Baoming; Dong,Changjun; Song,Zhen; Wang,Shilei; Qi,Yingguo; Wang,Jiali; Gu,Zengquan

doi:10.3892/etm.2016.3546

September-2016 Volume 12 Issue 3

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September-2016 Volume 12 Issue 3

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Article

Deep vein thrombosis is accurately predicted by comprehensive analysis of the levels of microRNA-96 and plasma D-dimer

Authors:
- Xuesheng Xie
- Changpeng Liu
- Wei Lin
- Baoming Zhan
- Changjun Dong
- Zhen Song
- Shilei Wang
- Yingguo Qi
- Jiali Wang
- Zengquan Gu
View Affiliations / Copyright

Affiliations: Department of Orthopedics, Laiwu People's Hospital, Laiwu, Shandong 271100, P.R. China
Pages: 1896-1900
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Published online on: July 26, 2016

https://doi.org/10.3892/etm.2016.3546
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Abstract

The aim of the present study was to investigate the association between platelet microRNA-96 (miR-96) expression levels and the occurrence of deep vein thrombosis (DVT) in orthopedic patients. A total of consecutive 69 orthopedic patients with DVT and 30 healthy individuals were enrolled. Ultrasonic color Doppler imaging was performed on lower limb veins after orthopedic surgery to determine the occurrence of DVT. An enzyme-linked fluorescent assay was performed to detect the levels of D‑dimer in plasma. A quantitative polymerase chain reaction assay was performed to determine the expression levels of miR‑96. Expression levels of platelet miR‑96 were significantly increased in orthopedic patients after orthopedic surgery. miR‑96 expression levels in orthopedic patients with DVT at days 1, 3 and 7 after orthopedic surgery were significantly increased when compared with those in the control group. The increased miR‑96 expression levels were correlated with plasma D‑dimer levels in orthopedic patients with DVT. However, for the orthopedic patients in the non-DVT group following surgery, miR‑96 expression levels were correlated with plasma D‑dimer levels. In summary, the present results suggest that the expression levels of miR‑96 may be associated with the occurrence of DVT. The occurrence of DVT may be accurately predicted by comprehensive analysis of the levels of miR-96 and plasma D-dimer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Deep vein thrombosis is accurately predicted by comprehensive analysis of the levels of microRNA-96 and plasma D-dimer

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