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Article Open Access

Protective effect of Shenfu injection preconditioning on lung ischemia-reperfusion injury

  • Authors:
    • Hong Zhang
    • Zhanhai Wan
    • Xiang Yan
    • De‑Gui Wang
    • Yufang Leng
    • Yongqiang Liu
    • Yan Zhang
    • Haijun Zhang
    • Xuena Han
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Gerontology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Anatomy and Histology, Lanzhou University School of Medicine, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1663-1670
    |
    Published online on: July 26, 2016
       https://doi.org/10.3892/etm.2016.3549
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Abstract

Lung ischemia-reperfusion injury remains a problem in thoracic surgery, as minimal progress has been made concerning its prevention and control. In the present study, the protective effects and the underlying mechanism of Shenfu injection preconditioning on a rat lung ischemia-reperfusion model was investigated. Shenfu injection is a well‑known Chinese traditional medicine, which is composed of Red Radix Ginseng and Radix Aconitum carmichaelii, with ginseng saponin and aconitum alkaloids as the active ingredients. A total of 72 specific pathogen‑free, healthy male Wistar rats were randomly divided into control, model and Shenfu injection (10 ml/kg injection prior to injury) groups and were assessed at the following points: Ischemia 45 min; reperfusion 60 min; and reperfusion 120 min. Blood collected from the aorta abdominalis was cryopreserved at ‑70˚C for the analysis of malondialdehyde (MDA) and superoxide dismutase (SOD) activity. Lung tissues were divided into three equal sections in order to assess the wet‑to‑dry (W/D) lung ratio, tumor necrosis factor (TNF)‑α expression levels, myeloperoxidase (MPO) activity, alveolar damage, total protein and hematoxylin and eosin staining. The results demonstrated that the lung W/D weight ratio, TNF‑α expression levels and SOD activity in the Shenfu group were significantly lower at 120 min reperfusion (P<0.05), as compared with the model group. MPO and MDA activity significantly decreased following reperfusion at 60 and 120 min (P<0.05), as compared with the model group. In addition, the degree of alveolar damage in the Shenfu group was significantly decreased (P<0.05), as compared with the model group. In addition, compared with the model group, the degree of alveolar damage in the Shenfu group was significantly lower (P<0.05); however, no significant changes in total protein were observed. The extent of alveolar structural damage and the proportion of interstitial neutrophils and alveolar and interstitial red blood cells were lower in the Shenfu group, as compared with the model and control groups. Therefore, the results of the present study suggested that Shenfu injection may have protective effects on lung ischemia-reperfusion injury.
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1 

Yang CL, Tsai PS and Huang CJ: Effects of dexmedetomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury. Acta Anaesthesiol Taiwan. 46:151–159. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Harada M, Oto T, Otani S and Miyoshi K: A neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion. Gen Thorac Cardiovasc Surg. 63:645–651. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Belaïdi E, Béguin PC, Ribuot C and Godin-Ribuot D: Hypoxic preconditioning: Role of transcription factor HIF-1alpha. Ann Cardiol Angeiol (Paris). 55:70–73. 2006.(In French). View Article : Google Scholar : PubMed/NCBI

4 

Kurt A, Tumkaya L, Kalkan Y, Turut H, Cure MC, Cure E, Sehitoglu I, Bilgin H and Usta M: Is adalimumab protective in ischemia-reperfusion injury in lung? Iran J Basic Med Sci. 18:1093–1099. 2015.PubMed/NCBI

5 

Zhang XJ, Song L, Zhou ZG and Wang XM: Effect of shenfu injection on gastrointestinal microcirculation in rabbits after myocardial ischemia-reperfusion injury. World J Gastroenterol. 12:4389–4391. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Dong G and Shen B: Clinical effect of shenfu injection in the sepsis bundle treatment of septic shock. Zhong Guo Zhong Yi Ji Zheng. 23:944–945. 2014.(In Chinese).

7 

Zheng SY, Sun J, Zhao X and Xu JG: Protective effect of shen-fu on myocardial ischemia-reperfusion injury in rats. Am J Chin Med. 32:209–220. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Yang SL, Feng ZQ, Wu LS and Li LH: Shenfu injection prevents kidney from acute ischemia-reperfusion injury in rabbits. Zhong Guo Bing Li Sheng Li Za Zhi. 19:353–356. 2003.(In Chinese).

9 

Long SQ, Liao GY, He WF, Wang B, Deng H, Zhang HB, Chai XS, Cau JZ and Wu WY: Influence of shenfu injection on the quality of life of lung cancer patients receiving chemotherapy. Nan Fang Yi Ke Da Xue Xue Bao. 31:2090–2092. 2011.(In Chinese). PubMed/NCBI

10 

Huang F, Chen X and Zhu J: Clinical study on the effects of shenfu injection in children with bronchial asthma. Zhong Guo Xian Dai Yi Sheng. 52:70–72. 2014.(In Chinese).

11 

Fang M: Clinical observation on treatment of 32 cases of chronic obstructive lung disease with Chinese medicine combined with Western medicine. Jiang Su Zhong Yi Yao. 39:22–23. 2007.(In Chinese).

12 

Wang J, Qiao LF and Yang GT: Role of Shenfu Injection in rats with systemic inflammatory response syndrome. Chin J Integr Med. 14:51–55. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Hu G, Liu XY, Xia ZY and Xiong GX: The effect of shenfu injection on the expression of NF-κB, ICAM-1, TNF-α after ischemia-reperfusion of intestinal mucosa in rats. Tong Ji Da Xue Xue Bao. 24:381–384. 2003.(In Chinese).

14 

Yun QC: Effect of combined methylprednisolone with shenfu injection on the treatment of children systemic inflammatory response syndrome. Zhong Guo Zhong Xi Yi Jie He Ji Jiu Za Zhi. 9:155–156. 2002.(In Chinese).

15 

Zhang Q, Li CS, Wang S and Gu W: Effects of Chinese medicine Shen-Fu injection on the expression of inflammatory cytokines and complements during post-resuscitation immune dysfunction in a porcine model. Chin J Integr Med. 22:101–109. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Chai J, Wang DW and Shen J: Effect of sevoflurane on pulmonary oxygen free radicals in ischemia-reperfusion rats. Shi Yong Yao Wu Yu Lin Chuang. 12:156–159. 2009.(In Chinese).

17 

Du JZ and Dong BR: The effect of atorvastatin on pulmonary ischemia-reperfusion injury in rats. Zhong Guo Ji Ceng Yi Yao. 13:2027–2028. 2006.(In Chinese).

18 

Song J, Jiang M, Qi G, Xie Y, Wang H, Tian Y, Qu J, Zhang X and Li H: Effect of airway humidification on lung injury induced by mechanical ventilation. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 26:884–889. 2014.(In Chinese). PubMed/NCBI

19 

Dawn B and Bolli R: HO-1 induction by HIF-1: A new mechanism for delayed cardioprotection? Am J Physiol Heart Circ Physiol. 289:H522–H524. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Laubach VE and Sharma AK: Mechanisms of lung ischemia-reperfusion injury. Curr Opin Organ Transplant. 21:246–252. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Lehmann S, Barten MJ, Topf C, Garbade J, Dhein S, Mohr FW and Bittner HB: Donor type impact on ischemia-reperfusion injury after lung transplantation. Ann Thorac Surg. 93:913–919; discussion 919–920. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Zhang Z, Shen H, Qin HD, Ma MZ and Xu Y: Protective effect of N-acetylcysteine against pneumocyte apoptosis during ischemia/reperfusion injury of lung in rats. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 24:111–115. 2012.(In Chinese). PubMed/NCBI

23 

Reyes YA, Shimoyama T, Akamatsu H and Sunamori M: MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation. Eur J Cardiothorac Surg. 29:304–311. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Ferrari RS and Andrade CF: Oxidative Stress and Lung Ischemia-Reperfusion Injury. Oxid Med Cell Longev. 2015:5909872015. View Article : Google Scholar : PubMed/NCBI

25 

Wu Y, Xia ZY, Meng QT, Zhu J, Lei S, Xu J and Dou J: Shen-Fu injection preconditioning inhibits myocardial ischemia-reperfusion injury in diabetic rats: Activation of eNOS via the PI3K/Akt pathway. J Biomed Biotechnol. 2011:3846272011. View Article : Google Scholar : PubMed/NCBI

26 

Jin WY, Sun W, Zhang YZ, Li HY and Chen MZ: Effect of benidipine on plasma level of calcitonin gene-related peptide in essential hypertension. Zhonghua Nei Ke Za Zhi. 43:747–749. 2004.(In Chinese). PubMed/NCBI

27 

Ma RH, Li Y and Wang YX: Postconditioning with shenfu injection protects against pulmonary ischemia/reperfusion injury in rats MA. Zhong Guo Yao Wu Yu Lin Chuang. 13:437–439. 2013.(In Chinese).

28 

Xia ZY, Meng QT, Zhang F and Chen XD: Effect of shenfu injection (ginesenoside and aconite alkaloid) on the apoptosis of intestinal mucosal epithelial cells and its mechanism during ischemia-reperfusion in rats. Zhong Hua Chuang Shang Za Zhi. 7:363–367. 2004.(In Chinese).

29 

Wang ZF: The protective of Shenfu injections on hemodynamics and myocardial enzyme after myocardial ischemia/reperfusion injury. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 27:155–157. 2011.(In Chinese). PubMed/NCBI

30 

Gu W, Hou X, Zhou H and Li C: Protective effect of shen-fu injection on neuronal mitochondrial function in a porcine model of prolonged cardiac arrest. Evid Based Complement Alternat Med. 2014:5238472014. View Article : Google Scholar : PubMed/NCBI

31 

Christie JD, Edward LB, Aurora P, Dobbels F, Kirk R, Rahmel AO, Stehlik J, Taylor DO, Kucheryavaya AY and Hertz MI: The Registry of the International Society for Heart and Lung Transplantation: Twenty-sixth Official Adult Lung and Heart-Lung Transplantation Report - 2009. J Heart Lung Transplant. 28:1031–1049. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Ng CS, Wan S, Yim AP and Arifi AA: Pulmonary dysfunction after cardiac surgery. Chest. 121:1269–1277. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Friedrich I, Spillner J, Lu EX, Bartling B, Barnscheid M, Sablotzki A, Schade U, Reidemeister JC, Silber RE, Gunther A and Borgermann J: Ischemic pre-conditioning of 5 minutes but not of 10 minutes improves lung function after warm ischemia in a canine model. J Heart Lung Transplant. 20:985–995. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Hanci V, Yurdakan G, Yurtlu S, Turan IO and Sipahi EY: Protective effect of dexmedetomidine in a rat model of α-naphthylthiourea-induced acute lung injury. J Surg Res. 178:424–430. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Kesici S, Turkmen UA, Kesici U, Altan A and Pulat E: Effects of enteral and parenteral glutamine on intestinal mucosa and on levels of blood glutamine, tumor necrosis factor-alpha, and interleukin-10 in an experimental sepsis model. Saudi Med J. 33:262–271. 2012.PubMed/NCBI

36 

Fu PK, Wu CL, Tsai TH and Hsieh CL: Anti-inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats. Evid Based Complement Alternat Med. 2012:224546872012. View Article : Google Scholar

37 

Inci I, Dutly A, Inci D, Boehler A and Weder W: Recipient treatment with trimetazidine improves graft function and protects energy status after lung transplantation. J Heart Lung Transplant. 20:1115–1122. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Li YC and Jiang Z: Ulinastatin, a human protease inhibitor, attenuates ischemia-reperfusion lung injury. Fu Dan Xue Bao Yi Xue Ban Bian Ji Wei Yuan Hui. 31:182–186. 2004.(In Chinese).

39 

Xu M, Wen XH, Chen SP, An XX and Xu HY: Addition of ulinastatin to preservation solution promotes protection against ischemia-reperfusion injury in rabbit lung. Chin Med J (Engl). 124:2179–2183. 2011.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Wan Z, Yan X, Wang DG, Leng Y, Liu Y, Zhang Y, Zhang H and Han X: Protective effect of Shenfu injection preconditioning on lung ischemia-reperfusion injury. Exp Ther Med 12: 1663-1670, 2016.
APA
Zhang, H., Wan, Z., Yan, X., Wang, D., Leng, Y., Liu, Y. ... Han, X. (2016). Protective effect of Shenfu injection preconditioning on lung ischemia-reperfusion injury. Experimental and Therapeutic Medicine, 12, 1663-1670. https://doi.org/10.3892/etm.2016.3549
MLA
Zhang, H., Wan, Z., Yan, X., Wang, D., Leng, Y., Liu, Y., Zhang, Y., Zhang, H., Han, X."Protective effect of Shenfu injection preconditioning on lung ischemia-reperfusion injury". Experimental and Therapeutic Medicine 12.3 (2016): 1663-1670.
Chicago
Zhang, H., Wan, Z., Yan, X., Wang, D., Leng, Y., Liu, Y., Zhang, Y., Zhang, H., Han, X."Protective effect of Shenfu injection preconditioning on lung ischemia-reperfusion injury". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1663-1670. https://doi.org/10.3892/etm.2016.3549
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Wan Z, Yan X, Wang DG, Leng Y, Liu Y, Zhang Y, Zhang H and Han X: Protective effect of Shenfu injection preconditioning on lung ischemia-reperfusion injury. Exp Ther Med 12: 1663-1670, 2016.
APA
Zhang, H., Wan, Z., Yan, X., Wang, D., Leng, Y., Liu, Y. ... Han, X. (2016). Protective effect of Shenfu injection preconditioning on lung ischemia-reperfusion injury. Experimental and Therapeutic Medicine, 12, 1663-1670. https://doi.org/10.3892/etm.2016.3549
MLA
Zhang, H., Wan, Z., Yan, X., Wang, D., Leng, Y., Liu, Y., Zhang, Y., Zhang, H., Han, X."Protective effect of Shenfu injection preconditioning on lung ischemia-reperfusion injury". Experimental and Therapeutic Medicine 12.3 (2016): 1663-1670.
Chicago
Zhang, H., Wan, Z., Yan, X., Wang, D., Leng, Y., Liu, Y., Zhang, Y., Zhang, H., Han, X."Protective effect of Shenfu injection preconditioning on lung ischemia-reperfusion injury". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1663-1670. https://doi.org/10.3892/etm.2016.3549
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