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Article

Similar outcomes for anti-tumor necrosis factor-α antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula

  • Authors:
    • Xutao Lin
    • Dejun Fan
    • Zerong Cai
    • Lei Lian
    • Xiaowen He
    • Min Zhi
    • Xiaojian Wu
    • Xiaosheng He
    • Ping Lan
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510655, P.R. China, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510655, P.R. China
  • Pages: 1939-1945
    |
    Published online on: July 26, 2016
       https://doi.org/10.3892/etm.2016.3552
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Abstract

Anal fistula is common in patients with Crohn's disease (CD) and leads to significant morbidity. The efficacy of seton drainage combined with anti-tumor necrosis factor‑α monoclonal antibody (anti‑TNF‑α) or immunosuppressant in the treatment of CD‑related anal fistula remains unclear. The aim of the present study was to compare the efficacy between seton drainage combined with anti-TNF-α and seton drainage combined with immunosuppressant postoperatively on the treatment of CD‑related anal fistula. A total of 65 patients with CD‑related anal fistula who had received seton drainage combined with postoperative medication were divided into an antibiotics only group, anti‑TNF‑α group and immunosuppressant group; all patients were treated with antibiotics. Fistula closure, external orifice exudation rate and recurrence rate were assessed among these patients. The duration of follow‑up ranged from 3 to 84 months with an average of 25.3 months. There were 11 (16.9%) cases of recurrence after seton drainage, 9 of which underwent a second seton drainage. In the total study group, 34 (52.3%) cases achieved complete fistula closure, and 10 (15.4%) cases showed external orifice exudation. No significant difference was found among these three groups, regarding fistula closure rate, closure time of fistula and recurrence rate. The external orifice exudation rate was significantly higher in the anti-TNF-α group compared with the antibiotics only group and immunosuppressant group (P=0.004 and P=0.026, respectively). Seton drainage is an effective treatment for CD‑related anal fistula. The efficacy is similar whether combined with anti-TNF-α or immunosuppressant.
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1 

Schwartz DA, Loftus EV Jr, Tremaine WJ, Panaccione R, Harmsen WS, Zinsmeister AR and Sandborn WJ: The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota. Gastroenterology. 122:875–880. 2002. View Article : Google Scholar : PubMed/NCBI

2 

American Gastroenterological Association Clinical Practice Committee, . American Gastroenterological Association medical position statement: Perianal Crohn's disease. Gastroenterology. 125:1503–1507. 2003.PubMed/NCBI

3 

Lapidus A: Crohn's disease in Stockholm County during 1990–2001: An epidemiological update. World J Gastroenterol. 12:75–81. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Tang LY, Rawsthorne P and Bernstein CN: Are perineal and luminal fistulas associated in Crohn's disease? A population-based study. Clin Gastroenterol Hepatol. 4:1130–1134. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Peyrin-Biroulet L, Loftus EV Jr, Colombel JF and Sandborn WJ: The natural history of adult Crohn's disease in population-based cohorts. Am J Gastroenterol. 105:289–297. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Bouguen G, Siproudhis L, Gizard E, Wallenhorst T, Billioud V, Bretagne JF, Bigard MA and Peyrin-Biroulet L: Long-term outcome of perianal fistulizing Crohn's disease treated with infliximab. Clin Gastroenterol Hepatol. 11:975–981. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Mizrahi N, Wexner SD, Zmora O, Da Silva G, Efron J, Weiss EG, Vernava AM III and Nogueras JJ: Endorectal advancement flap: Are there predictors of failure? Dis Colon Rectum. 45:1616–1621. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Sonoda T, Hull T, Piedmonte MR and Fazio VW: Outcomes of primary repair of anorectal and rectovaginal fistulas using the endorectal advancement flap. Dis Colon Rectum. 45:1622–1628. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Löffler T, Welsch T, Mühl S, Hinz U, Schmidt J and Kienle P: Long-term success rate after surgical treatment of anorectal and rectovaginal fistulas in Crohn's disease. Int J Colorectal Dis. 24:521–526. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Schwandner O: Video-assisted anal fistula treatment (VAAFT) combined with advancement flap repair in Crohn's disease. Tech Coloproctol. 17:221–225. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Ingle SB and Loftus EV Jr: The natural history of perianal Crohn's disease. Dig Liver Dis. 39:963–969. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Mahadev S, Young JM, Selby W and Solomon MJ: Quality of life in perianal Crohn's disease: What do patients consider important? Dis Colon Rectum. 54:579–585. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Yamamoto T, Allan RN and Keighley MR: Effect of fecal diversion alone on perianal Crohn's disease. World J Surg. 24:1258–1263. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Bernstein CN, Fried M, Krabshuis JH, Cohen H, Eliakim R, Fedail S, Gearry R, Goh KL, Hamid S, Khan AG, et al: World Gastroenterology Organization Practice Guidelines for the diagnosis and management of IBD in 2010. Inflamm Bowel Dis. 16:112–124. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Sandborn WJ, Fazio VW, Feagan BG and Hanauer SB: American Gastroenterological Association Clinical Practice Committee: AGA technical review on perianal Crohn's disease. Gastroenterology. 125:1508–1530. 2003. View Article : Google Scholar : PubMed/NCBI

16 

The Chinese Medical Association Digestion of Neurology IBEG, . The consensus on diagnosis and management of inflammatory bowel disease (Guangzhou, 2012). Zhonghua Nei Ke Za Zhi. 2012:818–831. 2012.(In Chinese).

17 

Gecse KB, Bemelman W, Kamm MA, Stoker J, Khanna R, Ng SC, Panés J, van Assche G, Liu Z, Hart A, et al: World Gastroenterology Organization, International Organisation for Inflammatory Bowel Diseases IOIBD and European Society of Coloproctology and Robarts Clinical Trials: A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease. Gut. 63:1381–1392. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Huang J, Liao C, Wu L, Cao Y and Gao F: A meta-analysis of randomized controlled trials comparing antibacterial therapy with placebo in Crohn's disease. Colorectal Dis. 13:617–626. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Thia KT, Mahadevan U, Feagan BG, Wong C, Cockeram A, Bitton A, Bernstein CN and Sandborn WJ: Ciprofloxacin or metronidazole for the treatment of perianal fistulas in patients with Crohn's disease: A randomized, double-blind, placebo-controlled pilot study. Inflamm Bowel Dis. 15:17–24. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Dewint P, Hansen BE, Verhey E, Oldenburg B, Hommes DW, Pierik M, Ponsioen CI, van Dullemen HM, Russel M, van Bodegraven AA and van der Woude CJ: Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohn's disease: A randomised, double-blind, placebo controlled trial (ADAFI). Gut. 63:292–299. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Present DH, Rutgeerts P, Targan S, Hanauer SB, Mayer L, van Hogezand RA, Podolsky DK, Sands BE, Braakman T, DeWoody KL, et al: Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med. 340:1398–1405. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Sands BE, Anderson FH, Bernstein CN, Chey WY, Feagan BG, Fedorak RN, Kamm MA, Korzenik JR, Lashner BA, Onken JE, et al: Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med. 350:876–885. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Ochsenkühn T, Göke B and Sackmann M: Combining infliximab with 6-mercaptopurine/azathioprine for fistula therapy in Crohn's disease. Am J Gastroenterol. 97:2022–2025. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Hanauer SB, Sandborn WJ, Rutgeerts P, Fedorak RN, Lukas M, MacIntosh D, Panaccione R, Wolf D and Pollack P: Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology. 130:323–333. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Sandborn WJ, Rutgeerts P, Enns R, Hanauer SB, Colombel JF, Panaccione R, D'Haens G, Li J, Rosenfeld MR, Kent JD and Pollack PF: Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial. Ann Intern Med. 146:829–838. 2007. View Article : Google Scholar : PubMed/NCBI

26 

El-Gazzaz G, Hull T and Church JM: Biological immunomodulators improve the healing rate in surgically treated perianal Crohn's fistulas. Colorectal Dis. 14:1217–1223. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Hotokezaka M, Ikeda T, Uchiyama S, Tsuchiya K and Chijiiwa K: Results of seton drainage and infliximab infusion for complex anal Crohn's disease. Hepatogastroenterology. 58:1189–1192. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Kasparek MS, Glatzle J, Temeltcheva T, Mueller MH, Koenigsrainer A and Kreis ME: Long-term quality of life in patients with Crohn's disease and perianal fistulas: Influence of fecal diversion. Dis Colon Rectum. 50:2067–2074. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lin X, Fan D, Cai Z, Lian L, He X, Zhi M, Wu X, He X and Lan P: Similar outcomes for anti-tumor necrosis factor-α antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula. Exp Ther Med 12: 1939-1945, 2016.
APA
Lin, X., Fan, D., Cai, Z., Lian, L., He, X., Zhi, M. ... Lan, P. (2016). Similar outcomes for anti-tumor necrosis factor-α antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula. Experimental and Therapeutic Medicine, 12, 1939-1945. https://doi.org/10.3892/etm.2016.3552
MLA
Lin, X., Fan, D., Cai, Z., Lian, L., He, X., Zhi, M., Wu, X., He, X., Lan, P."Similar outcomes for anti-tumor necrosis factor-α antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula". Experimental and Therapeutic Medicine 12.3 (2016): 1939-1945.
Chicago
Lin, X., Fan, D., Cai, Z., Lian, L., He, X., Zhi, M., Wu, X., He, X., Lan, P."Similar outcomes for anti-tumor necrosis factor-α antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1939-1945. https://doi.org/10.3892/etm.2016.3552
Copy and paste a formatted citation
x
Spandidos Publications style
Lin X, Fan D, Cai Z, Lian L, He X, Zhi M, Wu X, He X and Lan P: Similar outcomes for anti-tumor necrosis factor-α antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula. Exp Ther Med 12: 1939-1945, 2016.
APA
Lin, X., Fan, D., Cai, Z., Lian, L., He, X., Zhi, M. ... Lan, P. (2016). Similar outcomes for anti-tumor necrosis factor-α antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula. Experimental and Therapeutic Medicine, 12, 1939-1945. https://doi.org/10.3892/etm.2016.3552
MLA
Lin, X., Fan, D., Cai, Z., Lian, L., He, X., Zhi, M., Wu, X., He, X., Lan, P."Similar outcomes for anti-tumor necrosis factor-α antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula". Experimental and Therapeutic Medicine 12.3 (2016): 1939-1945.
Chicago
Lin, X., Fan, D., Cai, Z., Lian, L., He, X., Zhi, M., Wu, X., He, X., Lan, P."Similar outcomes for anti-tumor necrosis factor-α antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1939-1945. https://doi.org/10.3892/etm.2016.3552
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