Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Association between ABCB1 genetic polymorphism and the effect on epilepsy following phenytoin treatment

  • Authors:
    • Fei Sun
    • Bo‑Qiang Cao
    • Bo Wang
    • Shi‑Qiang Wu
    • De‑Hua Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China, Department of Pharmacy, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1780-1784
    |
    Published online on: July 27, 2016
       https://doi.org/10.3892/etm.2016.3553
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the study was to analyze the effect of ABCB1 genetic polymorphisms on the efficacy of phenytoin (PHT) treatment in epilepsy patients. In total, 200 epilepsy patients who were administered PHT were divided into the responsive and pharmaco-resistance groups depending on the clinical data of PHT treatment in epilepsy patients. The serum concentration of PHT was detected by high‑performance liquid chromatography (HPLC). ABCB1 polymorphisms were analyzed by the polymerase chain reaction restriction‑fragment length polymorphism method. The C1236T, C3435T and G2677T/A haplotypes were reconstructed for the ABCB1 gene using SHEsis programs. One‑way analysis of variance was used for data analysis. In ABCB1 C1236T, the rate of the CC genotype in pharmaco‑resistance (17.5%) was higher than that of the responsive group (2.1%), while the rate of the TT genotype in pharmaco‑resistance (41.6%) was lower than that of the responsive group (55.4%) (P<0.05). In ABCB1 G2677T/A, the rate of the GG genotype in pharmaco‑resistance (29.6%) was higher than that of the responsive group (9.7%), while the rate of the TT genotype in pharmaco‑resistance (4.6%) was lower than that of the responsive group (30.4%) (P<0.05). The rate of the TTC haploid in pharmaco-resistance (24.1%) was higher than that of the responsive group (8.8%) (P<0.05). The PHT serum concentration had no statistical significance in the patients with different genotypes. In conclusion, there was no association between ABCB1 genetic polymorphism and PHT serum concentration, although the polymorphisms affected the efficacy of PHT treatment in patients with epilepsy.
View Figures
View References

1 

Werhahn KJ: Epilepsy in the elderly. Dtsch Arztebl Int. 106:135–142. 2009.PubMed/NCBI

2 

Banerjee PN, Filippi D and Allen Hauser W: The descriptive epidemiology of epilepsy-a review. Epilepsy Res. 85:31–45. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Benn EK, Hauser WA, Shih T, Leary L, Bagiella E, Dayan P, Green R, Andrews H, Thurman DJ and Hesdorffer DC: Estimating the incidence of first unprovoked seizure and newly diagnosed epilepsy in the low-income urban community of Northern Manhattan, New York City. Epilepsia. 49:1431–1439. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Siddiqui A, Kerb R, Weale ME, Brinkmann U, Smith A, Goldstein DB, Wood NW and Sisodiya SM: Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med. 348:1442–1448. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Zimprich F, SunderPlassmann R, Stogmann E, Gleiss A, DalBianco A, Zimprich A, Plumer S, Baumgartner C and Mannhalter C: Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy. Neurology. 63:1087–1089. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Hung CC, Tai JJ, Lin CJ, Lee MJ and Liou HH: Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response. Pharmacogenomics. 6:411–417. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Vahab SA, Sen S, Ravindran N, Mony S, Mathew A, Vijayan N, Nayak G, Bhaskaranand N, Banerjee M and Satyamoorthy K: Analysis of genotype and haplotype effects of ABCB1 (MDR1) polymorphisms in the risk of medically refractory epilepsy in an Indian population. Drug Metab Pharmacokinet. 24:255–260. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Szoeke C, Sills GJ, Kwan P, Petrovski S, Newton M, Hitiris N, Baum L, Berkovic SF, Brodie MJ, Sheffield LJ, et al: Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: Data from international pharmacogenetic cohorts. Epilepsia. 50:1689–1696. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Lakhan R, Misra UK, Kalita J, Pradhan S, Gogtay NJ, Singh MK and Mittal B: No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population. Epilepsy Behav. 14:78–82. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Shahwan A, Murphy K, Doherty C, Cavalleri GL, Muckian C, Dicker P, McCarthy M, Kinirons P, Goldstein D and Delanty N: The controversial association of ABCB1 polymorphisms in refractory epilepsy: An analysis of multiple SNPs in an Irish population. Epilepsy Res. 73:192–198. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Seager J, Jamison DL, Wilson J, Hayward AR and Soothill JF: IgA deficiency, epilepsy, and phenytoin treatment. Lancet. 2:632–635. 1975. View Article : Google Scholar : PubMed/NCBI

12 

Kotsopoulos IA, van Merode T, Kessels FG, de Krom MC and Knottnerus JA: Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures. Epilepsia. 43:1402–1409. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Kwan P and Brodie MJ: Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia. 46:224–235. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Dombrowski SM, Desai SY, Marroni M, Cucullo L, Goodrich K, Bingaman W, Mayberg MR, Bengez L and Janigro D: Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia. 42:1501–1506. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Rizzi M, Caccia S, Guiso G, Richichi C, Gorter JA, Aronica E, Aliprandi M, Bagnati R, Fanelli R, D'Incalci M, et al: Limbic seizures induce P-glycoprotein in rodent brain: Functional implications for pharmacoresistance. J Neurosci. 22:5833–5839. 2002.PubMed/NCBI

16 

Sisodiya S: Drug resistance in epilepsy: Not futile, but complex? Lancet Neurol. 2:3312003. View Article : Google Scholar : PubMed/NCBI

17 

Bodó A, Bakos E, Szeri F, Váradi A and Sarkadi B: The role of multidrug transporters in drug availability, metabolism and toxicity. Toxicol Lett. 140-141:133–143. 2003. View Article : Google Scholar : PubMed/NCBI

18 

MacDonald RL, Rogers CJ and Twyman RE: Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture. J Physiol. 417:483–500. 1989. View Article : Google Scholar : PubMed/NCBI

19 

Löscher W and Potschka H: Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther. 301:7–14. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Sisodiya SM, Lin WR, Harding BN, Squier MV and Thom M: Drug resistance in epilepsy: Expression of drug resistance proteins in common causes of refractory epilepsy. Brain. 125:22–31. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Maleki M, Sayyah M, Kamgarpour F, Karimipoor M, Arab A, Rajabi A, Gharagozli K, Shamshiri AR and Shahsavand AE: Association between ABCB1-T1236C polymorphism and drug-resistant epilepsy in Iranian female patients. Iran Biomed J. 14:89–96. 2010.PubMed/NCBI

22 

Haerian BS, Lim KS, Mohamed EH, Tan HJ, Tan CT, Raymond AA, Wong CP, Wong SW and Mohamed Z: Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy. Seizure. 20:546–553. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun F, Cao BQ, Wang B, Wu SQ and Jiang DH: Association between ABCB1 genetic polymorphism and the effect on epilepsy following phenytoin treatment. Exp Ther Med 12: 1780-1784, 2016.
APA
Sun, F., Cao, B., Wang, B., Wu, S., & Jiang, D. (2016). Association between ABCB1 genetic polymorphism and the effect on epilepsy following phenytoin treatment. Experimental and Therapeutic Medicine, 12, 1780-1784. https://doi.org/10.3892/etm.2016.3553
MLA
Sun, F., Cao, B., Wang, B., Wu, S., Jiang, D."Association between ABCB1 genetic polymorphism and the effect on epilepsy following phenytoin treatment". Experimental and Therapeutic Medicine 12.3 (2016): 1780-1784.
Chicago
Sun, F., Cao, B., Wang, B., Wu, S., Jiang, D."Association between ABCB1 genetic polymorphism and the effect on epilepsy following phenytoin treatment". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1780-1784. https://doi.org/10.3892/etm.2016.3553
Copy and paste a formatted citation
x
Spandidos Publications style
Sun F, Cao BQ, Wang B, Wu SQ and Jiang DH: Association between ABCB1 genetic polymorphism and the effect on epilepsy following phenytoin treatment. Exp Ther Med 12: 1780-1784, 2016.
APA
Sun, F., Cao, B., Wang, B., Wu, S., & Jiang, D. (2016). Association between ABCB1 genetic polymorphism and the effect on epilepsy following phenytoin treatment. Experimental and Therapeutic Medicine, 12, 1780-1784. https://doi.org/10.3892/etm.2016.3553
MLA
Sun, F., Cao, B., Wang, B., Wu, S., Jiang, D."Association between ABCB1 genetic polymorphism and the effect on epilepsy following phenytoin treatment". Experimental and Therapeutic Medicine 12.3 (2016): 1780-1784.
Chicago
Sun, F., Cao, B., Wang, B., Wu, S., Jiang, D."Association between ABCB1 genetic polymorphism and the effect on epilepsy following phenytoin treatment". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1780-1784. https://doi.org/10.3892/etm.2016.3553
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team