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Article

IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study

  • Authors:
    • Liyuan Han
    • Yuanyuan Li
    • Linlin Tang
    • Zhongwei Chen
    • Tao Zhang
    • Sihan Chen
    • Shengyuan Liu
    • Xiaolin Peng
    • Yifeng Mai
    • Renjie Zhuo
    • Changyi Wang
    • Shiwei Duan
  • View Affiliations / Copyright

    Affiliations: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Key Laboratory of Etiology and Epidemiology, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China, Department of Endocrinology, The Affiliated Hospital of Ningbo Medical School, Ningbo University, Ningbo, Zhejiang 315000, P.R. China
  • Pages: 1849-1856
    |
    Published online on: July 27, 2016
       https://doi.org/10.3892/etm.2016.3554
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Abstract

Associations between insulin-like growth factor 2 mRNA‑binding protein 2 (IGF2BP2) rs11705701, insulin receptor substrate 1 rs7578326, gastric inhibitory polypeptide receptor rs10423928 and transcription factor 7-like 2 rs12255372 gene polymorphisms with prediabetes and type 2 diabetes (T2D) have not been evaluated in the Han Chinese population. These four genetic variants were investigated for their associations with prediabetes and T2D among 490 unrelated patients with T2D, 471 patients with prediabetes and 575 healthy controls. Sequenom MassARRAY software was used to genotype the patients for these variants. The Generalized Multifactor Dimensionality Reduction method was used to analyze the gene‑gene and gene‑environment interactions. A breakdown analysis by gender revealed a significant association of IGF2BP2 rs11705701 with prediabetes under the dominant genetic model in females following application of the Bonferroni correction (odds ratio = 0.26; 95% confidence interval = 0.10‑0.67; P=0.005). However, no significant associations were reported between any of the other three polymorphisms and T2D under any genetic models. Furthermore, there were no statistically significant gene‑gene or gene‑environment interactions when evaluated with the above association tests. The present case‑control study reveals a significant association between IGF2BP2 rs11705701 and prediabetes in female patients.
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1 

Yan L, Xu MT, Yuan L, Chen B, Xu ZR, Guo QH, Li Q, Duan Y, Huang Fu, Wang YJ, et al: Prevalence of dyslipidemia and its control in type 2 diabetes: A multicenter study in endocrinology clinics of China. J Clin Lipidol. 10:150–160. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, et al: 2010 China Noncommunicable Disease Surveillance Group: Prevalence and control of diabetes in Chinese adults. JAMA. 310:948–959. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Christiansen J, Kolte AM, Hansen Tv and Nielsen FC: IGF2 mRNA-binding protein 2: Biological function and putative role in type 2 diabetes. J Mol Endocrinol. 43:187–195. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Nielsen J, Christiansen J, LykkeAndersen J, Johnsen AH, Wewer UM and Nielsen FC: A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Biol. 19:1262–1270. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ and White MF: Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature. 352:73–77. 1991. View Article : Google Scholar : PubMed/NCBI

6 

Nandi A, Kitamura Y, Kahn CR and Accili D: Mouse models of insulin resistance. Physiol Rev. 84:623–647. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P and Lauro R: Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J. 15:2099–2111. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, BouatiaNaji N, Dupuis J, Jackson AU, et al: GIANT consortium; MAGIC investigators: Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 42:142–148. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Irwin N and Flatt PR: Therapeutic potential for GIP receptor agonists and antagonists. Best Pract Res Clin Endocrinol Metab. 23:499–512. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Yi F, Brubaker PL and Jin T: TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem. 280:1457–1464. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Villareal DT, Robertson H, Bell GI, Patterson BW, Tran H, Wice B and Polonsky KS: TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes. 59:479–485. 2010. View Article : Google Scholar : PubMed/NCBI

12 

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 33(Suppl 1): S62–S69. 2010.PubMed/NCBI

13 

Dupont WD and Plummer WD Jr: Power and sample size calculations. A review and computer program. Control Clin Trials. 11:116–128. 1990. View Article : Google Scholar : PubMed/NCBI

14 

Chistiakov DA, Nikitin AG, Smetanina SA, Bel'chikova LN, Suplotova LA, Shestakova MV and Nosikov VV: The rs11705701 G>A polymorphism of IGF2BP2 is associated with IGF2BP2 mRNA and protein levels in the visceral adipose tissue - a link to type 2 diabetes susceptibility. Rev Diabet Stud. 9:112–122. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Li X, Allayee H, Xiang AH, Trigo E, Hartiala J, Lawrence JM, Buchanan TA and Watanabe RM: Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans. Obesity (Silver Spring). 17:729–736. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, . Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, et al: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 316:1331–1336. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Chang Y-C, Liu P-H, Yu Y-H, Kuo SS, Chang TJ, Jiang YD, Nong JY, Hwang JJ and Chuang LM: Validation of type 2 diabetes risk variants identified by genome-wide association studies in Han Chinese population: A replication study and meta-analysis. PLoS One. 9:e950452014. View Article : Google Scholar : PubMed/NCBI

18 

Lasram K, Ben Halim N, Benrahma H, Mediene-Benchekor S, Arfa I, Hsouna S, Kefi R, Jamoussi H, Ben Ammar S, Bahri S, et al: Contribution of CDKAL1 rs7756992 and IGF2BP2 rs4402960 polymorphisms in type 2 diabetes, diabetic complications, obesity risk and hypertension in the Tunisian population. J Diabetes. 7:102–113. 2015. View Article : Google Scholar : PubMed/NCBI

19 

AlSinani S, Woodhouse N, AlMamari A, AlShafie O, AlShafaee M, AlYahyaee S, Hassan M, Jaju D, AlHashmi K, AlAbri M, et al: Association of gene variants with susceptibility to type 2 diabetes among Omanis. World J Diabetes. 6:358–366. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Wu J, Wu J, Zhou Y, Zou H, Guo S, Liu J, Lu L and Xu H: Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk. Acta Diabetologica. 49(Suppl 1): S87–S97. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Sonestedt E, Lyssenko V, Ericson U, Gullberg B, Wirfält E, Groop L and Orho-Melander M: Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort. J Clin Endocrinol Metab. 97:E810–E818. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, BouatiaNaji N, Dupuis J, Jackson AU, et al: Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 42:142–148. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, et al: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 42:579–589. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Haupt A, Thamer C, Heni M, Ketterer C, Machann J, Schick F, Machicao F, Stefan N, Claussen CD, Häring HU, et al: Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes. Diabetes. 59:747–750. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Dou H, Ma E, Yin L, Jin Y and Wang H: The association between gene polymorphism of TCF7L2 and type 2 diabetes in Chinese Han population: A meta-analysis. PLOS One. 8:e594952013. View Article : Google Scholar : PubMed/NCBI

26 

Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC and Li MD: A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet. 80:1125–1137. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han L, Li Y, Tang L, Chen Z, Zhang T, Chen S, Liu S, Peng X, Mai Y, Zhuo R, Zhuo R, et al: IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study. Exp Ther Med 12: 1849-1856, 2016.
APA
Han, L., Li, Y., Tang, L., Chen, Z., Zhang, T., Chen, S. ... Duan, S. (2016). IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study. Experimental and Therapeutic Medicine, 12, 1849-1856. https://doi.org/10.3892/etm.2016.3554
MLA
Han, L., Li, Y., Tang, L., Chen, Z., Zhang, T., Chen, S., Liu, S., Peng, X., Mai, Y., Zhuo, R., Wang, C., Duan, S."IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study". Experimental and Therapeutic Medicine 12.3 (2016): 1849-1856.
Chicago
Han, L., Li, Y., Tang, L., Chen, Z., Zhang, T., Chen, S., Liu, S., Peng, X., Mai, Y., Zhuo, R., Wang, C., Duan, S."IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1849-1856. https://doi.org/10.3892/etm.2016.3554
Copy and paste a formatted citation
x
Spandidos Publications style
Han L, Li Y, Tang L, Chen Z, Zhang T, Chen S, Liu S, Peng X, Mai Y, Zhuo R, Zhuo R, et al: IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study. Exp Ther Med 12: 1849-1856, 2016.
APA
Han, L., Li, Y., Tang, L., Chen, Z., Zhang, T., Chen, S. ... Duan, S. (2016). IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study. Experimental and Therapeutic Medicine, 12, 1849-1856. https://doi.org/10.3892/etm.2016.3554
MLA
Han, L., Li, Y., Tang, L., Chen, Z., Zhang, T., Chen, S., Liu, S., Peng, X., Mai, Y., Zhuo, R., Wang, C., Duan, S."IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study". Experimental and Therapeutic Medicine 12.3 (2016): 1849-1856.
Chicago
Han, L., Li, Y., Tang, L., Chen, Z., Zhang, T., Chen, S., Liu, S., Peng, X., Mai, Y., Zhuo, R., Wang, C., Duan, S."IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1849-1856. https://doi.org/10.3892/etm.2016.3554
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