Open Access

Effect of glycerol on sustained insulin release from PVA hydrogels and its application in diabetes therapy

  • Authors:
    • Yunpeng Cai
    • Junyi Che
    • Minglu Yuan
    • Xiaohong Shi
    • Wei Chen
    • Wei‑En Yuan
  • View Affiliations

  • Published online on: August 12, 2016     https://doi.org/10.3892/etm.2016.3593
  • Pages: 2039-2044
  • Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the effects of glycerol on the physical properties and release of an insulin‑loaded polyvinyl alcohol (PVA) hydrogel film. The insulin‑loaded hydrogel composite film was produced using the freeze‑thawing method, after which the in vitro swelling ratio, transmittance and insulin release, and the in vivo pharmacodynamics, of hydrogels containing various volumes of glycerol were investigated. The results demonstrated that the addition of glycerol reduced the swelling ratio and increased the softness of the PVA hydrogel film. An analysis of insulin release in vitro and of the hypoglycemic effects in rats demonstrated that the PVA hydrogel film had a sustained release of insulin and long‑acting effect over 10 days. The results of the present study suggested that, as a hydrophilic plasticizer, glycerol was able to enhance the release of insulin in the early stage of release profile by enhancing the formation of water channels, although the total swelling ratio was decreased. Therefore, the insulin‑loaded glycerol/PVA hydrogel film may be a promising sustained‑release preparation for the treatment of diabetes.

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October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Cai Y, Che J, Yuan M, Shi X, Chen W and Yuan WE: Effect of glycerol on sustained insulin release from PVA hydrogels and its application in diabetes therapy. Exp Ther Med 12: 2039-2044, 2016
APA
Cai, Y., Che, J., Yuan, M., Shi, X., Chen, W., & Yuan, W. (2016). Effect of glycerol on sustained insulin release from PVA hydrogels and its application in diabetes therapy. Experimental and Therapeutic Medicine, 12, 2039-2044. https://doi.org/10.3892/etm.2016.3593
MLA
Cai, Y., Che, J., Yuan, M., Shi, X., Chen, W., Yuan, W."Effect of glycerol on sustained insulin release from PVA hydrogels and its application in diabetes therapy". Experimental and Therapeutic Medicine 12.4 (2016): 2039-2044.
Chicago
Cai, Y., Che, J., Yuan, M., Shi, X., Chen, W., Yuan, W."Effect of glycerol on sustained insulin release from PVA hydrogels and its application in diabetes therapy". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2039-2044. https://doi.org/10.3892/etm.2016.3593