Effects of the short-term application of pantoprazole combined with aspirin and clopidogrel in the treatment of acute STEMI

Wei,Peng; Zhang,Yi-Gang; Ling,Lin; Tao,Zi-Qi; Ji,Li-Ya; Bai,Jie; Zong,Bin; Jiang,Chun-Ying; Zhang,Qian; Fu,Qiang; Yang,Xiang-Jun

doi:10.3892/etm.2016.3693

November-2016 Volume 12 Issue 5

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November-2016 Volume 12 Issue 5

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Article Open Access

Effects of the short-term application of pantoprazole combined with aspirin and clopidogrel in the treatment of acute STEMI

Authors:
- Peng Wei
- Yi-Gang Zhang
- Lin Ling
- Zi-Qi Tao
- Li-Ya Ji
- Jie Bai
- Bin Zong
- Chun-Ying Jiang
- Qian Zhang
- Qiang Fu
- Xiang-Jun Yang
View Affiliations / Copyright

Affiliations: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China, Department of Cardiology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215006, P.R. China, Departments of Science and Education, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China, Department of Geriatrics, Changhai Hospital of The Second Military Medical University, Shanghai 200433, P.R. China

Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2861-2864
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Published online on: September 9, 2016

https://doi.org/10.3892/etm.2016.3693
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Abstract

The aim of the present study was to determine the effects of the short-term application of pantoprazole on the co-treatment of acute ST-segment elevation myocardial infarction (STEMI) with aspirin and clopidogrel. A total of 207 acute patients showing primary symptoms of STEMI, who received successful emergent percutaneous coronary intervention treatment during hospitalization were randomly divided into two groups. In the test group proton pump inhibitors (PPIs), the patients were treated with a combination of aspirin and clopidogrel and pantoprazole, while those in the control group were treated only with aspirin and clopidogrel. Gastrointestinal bleeding events and major adverse cardiac events (MACEs) were observed in the two groups. Gastrointestinal bleeding events of the two groups mostly occurred within the first week of hospitalization, although the incidence in the PPIs group was significantly higher than that in the control group (p<0.05). However, no significant difference was observed for the incidence of MACEs between the two groups (p>0.05). In conclusion, the results of the present study have shown that the short‑term application of pantoprazole combined with aspirin and clopidogrel does not increase the incidence of MACEs in patients with acute STEMI, reduces the risk of gastrointestinal bleeding, and is thus worth promoting clinically, particularly for high‑risk groups.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of the short-term application of pantoprazole combined with aspirin and clopidogrel in the treatment of acute STEMI

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