Debridement in chronic osteomyelitis with benign osteopetrosis: A case report

Liu,Yu‑Ping; Lin,Xiang‑Hua; Yan,Man‑Yun; Lin,Bao‑Quan; Zhuo,Ming‑Ying

doi:10.3892/etm.2016.3706

November-2016 Volume 12 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

November-2016 Volume 12 Issue 5

Full Size Image

Case Report Open Access

Debridement in chronic osteomyelitis with benign osteopetrosis: A case report

Authors:
- Yu‑Ping Liu
- Xiang‑Hua Lin
- Man‑Yun Yan
- Bao‑Quan Lin
- Ming‑Ying Zhuo
View Affiliations / Copyright

Affiliations: Department of Endocrinology and Metabolism, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China, Department of Hematology, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China, Department of Otorhinolaryngology, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China

Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2811-2814
|
Published online on: September 15, 2016

https://doi.org/10.3892/etm.2016.3706
Expand metrics +

Abstract

Osteopetrosis is a rare bone disease caused by metabolic imbalances as a result of genetic mutations. For instance, autosomal dominant osteopetrosis is caused by a missense mutation of the C1CN7 gene. This was first reported in 1904 and is thought to be caused by osteoclastic dysfunction and an impaired bone resorption ability. An accumulation of cortical bone mass during the remodeling of the medullary bone may increase the bone density and give rise to a hard marble consistency. Osteopetrosis can be divided into benign and malignant forms; however, no curative treatment exists for benign osteopetrosis. The management of complications, such as chronic osteomyelitis and fractures, serves a key role in influencing the patient survival rates. Previous studies have demonstrated that a combined treatment of hyperbaric oxygen (HBO) lavage for debridement of the necrotic region and high‑dose systemic antibiotics may be effective in the management of osteopetrosis. The present study reported a case of chronic mandible osteomyelitis and fistula occurring in association with maxillary sinusitis, who was successfully treated by through nasal endoscopy, using repeated flushing and cleaning every 2 weeks as a form of debridement, in the absence of high‑dose antibiotics and HBO.

View Figures

View References

1	Smith NH: Albers-Schönberg disease (osteopetrosis). Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol. 22:699–710. 1966. View Article : Google Scholar : PubMed/NCBI
2	Bollerslev J: Autosomal dominant osteopetrosis: Bone metabolism and epidemiological, clinical, and hormonal aspects. Endocr Rev. 10:45–67. 1989. View Article : Google Scholar : PubMed/NCBI
3	García CM, García MA, García RG and Gil FM: Osteomyelitis of the mandible in a patient with osteopetrosis. Case report and review of the literature. J Maxillofac Oral Surg. 12:94–99. 2013. View Article : Google Scholar : PubMed/NCBI
4	Juggins KJ, Walton GM and Patel M: Osteomyelitis complicating osteopetrosis - a case report. Dent Update. 28:509–511. 2001.PubMed/NCBI
5	Battaglia MA, Drigo P, Laverda AM, Antolini A, Venuleo M, Miotti A and Pavone L: Juvenile osteomyelitis and osteopetrosis. A case report. Minerva Stomatol. 40:125–127. 1991.(In Italian). PubMed/NCBI
6	Bollerslev J and Andersen PE Jr: Radiological, biochemical and hereditary evidence of two types of autosomal dominant osteopetrosis. Bone. 9:7–13. 1988. View Article : Google Scholar : PubMed/NCBI
7	Coudert AE, de Vernejoul MC, Muraca M and Del Fattore A: Osteopetrosis and its relevance for the discovery of new functions associated with the skeleton. Int J Endocrinol. 3721562015.PubMed/NCBI
8	Bénichou OD, Laredo JD and de Vernejoul MC: Type II autosomal dominant osteopetrosis (Albers-Schönberg disease): Clinical and radiological manifestations in 42 patients. Bone. 26:87–93. 2000. View Article : Google Scholar : PubMed/NCBI
9	van Hove RP, de Jong T and Nolte PA: Autosomal dominant type I osteopetrosis is related with iatrogenic fractures in arthroplasty. Clin Orthop Surg. 6:484–488. 2014. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Debridement in chronic osteomyelitis with benign osteopetrosis: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles