In vitro and in vivo assessment of high-dose vitamin C against murine tumors

  • Authors:
    • Guoping Wang
    • Tao Yin
    • Yongsheng Wang
  • View Affiliations

  • Published online on: September 16, 2016     https://doi.org/10.3892/etm.2016.3707
  • Pages: 3058-3062
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Abstract

Vitamin C is widely used in clinical settings and is well known for its safety. Previous studies have shown the efficacy of intravenous vitamin C; however, intratumoral delivery of vitamin C has yet to be attempted. In the present study, the biological effects of high‑dose vitamin C on tumor cells were investigated in vitro by using the MTT assay and flow cytometry. When administered in vitro, high‑dose vitamin C inhibited the proliferation of murine colon and breast cancer cells, and induced tumor cell apoptosis. Cytotoxicity of vitamin C was partially reversed by N‑acetyl‑cysteine at a relatively low dosage. In addition, synergistic anti‑tumor effects of vitamin C and cisplatin were observed. In vivo, intratumoral delivery of vitamin C delayed tumor growth in murine solid tumor models. Considering its low toxicity and availability, the present study indicates that vitamin C may be a novel therapeutic method for patients with advanced tumors.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang G, Yin T and Wang Y: In vitro and in vivo assessment of high-dose vitamin C against murine tumors. Exp Ther Med 12: 3058-3062, 2016
APA
Wang, G., Yin, T., & Wang, Y. (2016). In vitro and in vivo assessment of high-dose vitamin C against murine tumors. Experimental and Therapeutic Medicine, 12, 3058-3062. https://doi.org/10.3892/etm.2016.3707
MLA
Wang, G., Yin, T., Wang, Y."In vitro and in vivo assessment of high-dose vitamin C against murine tumors". Experimental and Therapeutic Medicine 12.5 (2016): 3058-3062.
Chicago
Wang, G., Yin, T., Wang, Y."In vitro and in vivo assessment of high-dose vitamin C against murine tumors". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3058-3062. https://doi.org/10.3892/etm.2016.3707