Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2016 Volume 12 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2016 Volume 12 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinical treatment of malignant hyperthermia in three cases

  • Authors:
    • Tao Pan
    • Wenli Ji
    • Mengqi Nie
    • Yang Li
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care Medicine, Xiangyang Hospital Affiliated to Hubei University of Medicine, Wuhan, Hubei 441000, P.R. China
    Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2881-2884
    |
    Published online on: September 16, 2016
       https://doi.org/10.3892/etm.2016.3712
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Malignant hyperthermia (MH) is a rare life threatening inherited disorder that is triggered by drugs used for general anesthesia in susceptible persons. The symptoms include rapid increase of body temperature and severe muscle contractions. The present study includes 3 cases of MH and highlights the timely identification of symptoms for rescuing the patient. In case I, a 7-year-old male child underwent surgery with ketamine at a dose of 250 mg. After 4 h of operation, the child went through convulsions, high fever and succumbed within a few hours. High fever was not detected in a timely manner, which is one of the main symptoms of MH. In case II, a 12-year-old male child had convulsions and high fever after simple surgery caused by MH. Once confirmed, immediate measures were taken to lower the body temperature and the child was rescued. In case III, a male 57-year-old was admitted to hospital due to paraplegia. The patient underwent more critical conditions once symptoms of MH appeared. Additionally, antidote dantrolene was unavailable in the first and third case; thus, the progression of disease was not alleviated although active symptomatic and supportive treatment were employed.
View Figures
View References

1 

Kamińska E, Janas A and Osica P: Malignant hyperthermia - problem in dental surgery. An introductory report. Dev Period Med. 18:483–488. 2014.(In Polish). PubMed/NCBI

2 

Riazi S, Kraeva N, Muldoon SM, Dowling J, Ho C, Petre MA, Parness J, Dirksen RT and Rosenberg H: Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference. Can J Anaesth. 61:1040–1049. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Roesl C, Sato K, Schiemann A, Pollock N and Stowell KM: Functional characterisation of the R2452W ryanodine receptor variant associated with malignant hyperthermia susceptibility. Cell Calcium. 56:195–201. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Han H, Shao J and Zhang M: Diagnosis and treatment of malignant hyperthermia. Chinese General Medical Council. 11:314–317. 2008.(In Chinese).

5 

Itoh K, Nishibe S, Usuda Y and Kitamura A: Suspected case of postoperative malignant hyperthermia treated with dantrolene one week after neurosurgery. Masui. 63:1153–1155. 2014.(In Japanese). PubMed/NCBI

6 

Wang Y, Guo X and Luo A: Diagnosis and treatment progress of malignant hyperthermia. Chinese J Anesthesiol. 26:92–94. 2006.(In Chinese).

7 

Aderibigbe T, Lang BH, Rosenberg H, Chen Q and Li G: Cost-effectiveness analysis of stocking dantrolene in ambulatory surgery centers for the treatment of malignant hyperthermia. Anesthesiology. 120:1333–1338. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Brislin RP and Theroux MC: Core myopathies and malignant hyperthermia susceptibility: a review. Paediatr Anaesth. 23:834–841. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Nelson P and Litman RS: Malignant hyperthermia in children: an analysis of the North American malignant hyperthermia registry. Anesth Analg. 118:369–374. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Hoppe K, Schleip R, Lehmann-Horn F, Jäger H and Klingler W: Contractile elements in muscular fascial tissue - implications for in-vitro contracture testing for malignant hyperthermia. Anaesthesia. 69:1002–1008. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Kazantseva AA and Lebedinskiĭ KM: Modern diagnostic approaches to malignant hyperthermia susceptibility. Anesteziol Reanimatol. 59:64–68. 2014.(In Russian). PubMed/NCBI

12 

Gillies RL, Bjorksten AR, Du Sart D and Hockey BM: Analysis of the entire ryanodine receptor type 1 and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) coding regions for variants associated with malignant hyperthermia in Australian families. Anaesth Intensive Care. 43:157–166. 2015.PubMed/NCBI

13 

Yang Z, Wu X and Huang Z: Retrospective comparative analysis of malignant hyperthermia. Clin Med (Northfield, IL). 30:8–11. 2010.

14 

Wang YL, Guo XY and Luo AL: Malignant hyperthermia in Mainland China: an analysis of 34 cases. Chinese Anesthesiol. 26:107–109. 2006.(In Chinese).

15 

Larach MG, Brandom BW, Allen GC, Gronert GA and Lehman EB: Cardiac arrests and deaths associated with malignant hyperthermia in North America from 1987 to 2006: a report from the North American malignant hyperthermia registry of the malignant hyperthermia association of the United States. Anesthesiology. 108:603–611. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Nakamura N, Ueda T, Ishikawa R, Tasaka Y, Fukuuchi K and Sato N: Malignant hyperthermia developing during esophageal resection in an 82-year-old man. J Anesth. 22:464–466. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Riazi S, Larach MG, Hu C, Wijeysundera D, Massey C and Kraeva N: Malignant hyperthermia in Canada: characteristics of index anesthetics in 129 malignant hyperthermia susceptible probands. Anesth Analg. 118:381–387. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Vigilante JA: Case report: clearance to dive for a naval candidate with family history of malignant hyperthermia. Undersea Hyperb Med. 40:365–369. 2013.PubMed/NCBI

19 

Sousa CS and Cunha AL: Knowledge of nursing professionals of a surgical center regarding malignant hyperthermia. Rev Gaucha Enferm. 35:43–48. 2014.(In Portuguese). View Article : Google Scholar

20 

Rosero EB, Adesanya AO, Timaran CH and Joshi GP: Trends and outcomes of malignant hyperthermia in the United States, 2000 to 2005. Anesthesiology. 110:89–94. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Bina S, Capacchione J, Munkhuu B, Muldoon S and Bünger R: Is lymphocyte adenosine a diagnostic marker of clinical malignant hyperthermia? A pilot study. Crit Care Med. 43:584–593. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Larach MG, Brandom BW, Allen GC, Gronert GA and Lehman EB: Malignant hyperthermia deaths related to inadequate temperature monitoring, 2007℃2012: a report from the North American malignant hyperthermia registry of the malignant hyperthermia association of the United States. Anesth Analg. 119:1359–1366. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Liu Z, Fang L and Teng Y: Clinical diagnosis and treatment of malignant Hyperthermia. J Emerg Med. 16:1226–1227. 2010.

24 

Altamirano F, Eltit JM, Robin G, Linares N, Ding X, Pessah IN, Allen PD and López JR: Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle. J Biol Chem. 289:19180–19190. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Cain CL, Riess ML, Gettrust L and Novalija J: Malignant hyperthermia crisis: optimizing patient outcomes through simulation and interdisciplinary collaboration. AORN J:. 99:301–308. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Shaaban S, Ramos-Platt L, Gilles FH, Chan WM, Andrews C, De Girolami U, Demer J and Engle EC: RYR1 mutations as a cause of ophthalmoplegia, facial weakness, and malignant hyperthermia. JAMA Ophthalmol. 131:1532–1540. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Uchino S, Bellomo R, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Oudemans-van SH, Ronco C and Kellum JA: Continuous renal replacement therapy: A worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. Kidney) investigators. Intensive Care Med. 33:1563–1570. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Sheng R, Jiao JJ and Ting W: Research on multiple organ dysfunction syndrome with Ulinastatin and continuous blood purification therapy. J Emerg Med. 17:622–626. 2008.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pan T, Ji W, Nie M and Li Y: Clinical treatment of malignant hyperthermia in three cases. Exp Ther Med 12: 2881-2884, 2016.
APA
Pan, T., Ji, W., Nie, M., & Li, Y. (2016). Clinical treatment of malignant hyperthermia in three cases. Experimental and Therapeutic Medicine, 12, 2881-2884. https://doi.org/10.3892/etm.2016.3712
MLA
Pan, T., Ji, W., Nie, M., Li, Y."Clinical treatment of malignant hyperthermia in three cases". Experimental and Therapeutic Medicine 12.5 (2016): 2881-2884.
Chicago
Pan, T., Ji, W., Nie, M., Li, Y."Clinical treatment of malignant hyperthermia in three cases". Experimental and Therapeutic Medicine 12, no. 5 (2016): 2881-2884. https://doi.org/10.3892/etm.2016.3712
Copy and paste a formatted citation
x
Spandidos Publications style
Pan T, Ji W, Nie M and Li Y: Clinical treatment of malignant hyperthermia in three cases. Exp Ther Med 12: 2881-2884, 2016.
APA
Pan, T., Ji, W., Nie, M., & Li, Y. (2016). Clinical treatment of malignant hyperthermia in three cases. Experimental and Therapeutic Medicine, 12, 2881-2884. https://doi.org/10.3892/etm.2016.3712
MLA
Pan, T., Ji, W., Nie, M., Li, Y."Clinical treatment of malignant hyperthermia in three cases". Experimental and Therapeutic Medicine 12.5 (2016): 2881-2884.
Chicago
Pan, T., Ji, W., Nie, M., Li, Y."Clinical treatment of malignant hyperthermia in three cases". Experimental and Therapeutic Medicine 12, no. 5 (2016): 2881-2884. https://doi.org/10.3892/etm.2016.3712
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team