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Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis

  • Authors:
    • Jianxia Hu
    • Gang Zhao
    • Lize Zhang
    • Cuixia Qiao
    • Aiping Di
    • Hong Gao
    • Hong Xu
  • View Affiliations / Copyright

    Affiliations: Stem Cell Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Anorectal Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Endoscopy Center, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130000, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2983-2989
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    Published online on: September 20, 2016
       https://doi.org/10.3892/etm.2016.3724
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Abstract

One of the primary targets of the clinical treatment of ulcerative colitis (UC) is to repair the damaged colonic mucosa. Mesenchymal stem cells (MSCs) have therapeutic potential in regenerative medicine due to their differentiation capacity and their secretion of numerous bioactive molecules. The present study describes a clinical trial (trial registration no. NCT01221428) investigating the safety and therapeutic effect of MSCs derived from human umbilical cord on moderate to severe UC. Thirty-four patients with UC were included in group I and treated with MSC infusion in addition to the base treatment, and thirty‑six patients were in group II and treated with normal saline in addition to the base treatment. One month after therapy, 30/36 patients in group I showed good response, and diffuse and deep ulcer formation and severe inflammatory mucosa were improved markedly. During the follow up, the median Mayo score and histology score in group I were decreased while IBDQ scores were significantly improved compared with before treatment and group II (P<0.05). Compared with group II, there were no evident adverse reactions after MSC infusion in any of the patients in group I, and no chronic side effects or lingering effects appeared during the follow‑up period. In conclusion, MSC infusion might be a useful and safe therapy for treating UC.
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Copy and paste a formatted citation
Spandidos Publications style
Hu J, Zhao G, Zhang L, Qiao C, Di A, Gao H and Xu H: Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis. Exp Ther Med 12: 2983-2989, 2016.
APA
Hu, J., Zhao, G., Zhang, L., Qiao, C., Di, A., Gao, H., & Xu, H. (2016). Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis. Experimental and Therapeutic Medicine, 12, 2983-2989. https://doi.org/10.3892/etm.2016.3724
MLA
Hu, J., Zhao, G., Zhang, L., Qiao, C., Di, A., Gao, H., Xu, H."Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis". Experimental and Therapeutic Medicine 12.5 (2016): 2983-2989.
Chicago
Hu, J., Zhao, G., Zhang, L., Qiao, C., Di, A., Gao, H., Xu, H."Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis". Experimental and Therapeutic Medicine 12, no. 5 (2016): 2983-2989. https://doi.org/10.3892/etm.2016.3724
Copy and paste a formatted citation
x
Spandidos Publications style
Hu J, Zhao G, Zhang L, Qiao C, Di A, Gao H and Xu H: Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis. Exp Ther Med 12: 2983-2989, 2016.
APA
Hu, J., Zhao, G., Zhang, L., Qiao, C., Di, A., Gao, H., & Xu, H. (2016). Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis. Experimental and Therapeutic Medicine, 12, 2983-2989. https://doi.org/10.3892/etm.2016.3724
MLA
Hu, J., Zhao, G., Zhang, L., Qiao, C., Di, A., Gao, H., Xu, H."Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis". Experimental and Therapeutic Medicine 12.5 (2016): 2983-2989.
Chicago
Hu, J., Zhao, G., Zhang, L., Qiao, C., Di, A., Gao, H., Xu, H."Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis". Experimental and Therapeutic Medicine 12, no. 5 (2016): 2983-2989. https://doi.org/10.3892/etm.2016.3724
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