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Article

Protective effect of higenamine ameliorates collagen‑induced arthritis through heme oxygenase‑1 and PI3K/Akt/Nrf‑2 signaling pathways

  • Authors:
    • Wenjiang Duan
    • Jianmin Chen
    • Yu Wu
    • Yong Zhang
    • Yuansheng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Jingdu Hospital, Nanjing, Jiangsu 210000, P.R. China
  • Pages: 3107-3112
    |
    Published online on: September 20, 2016
       https://doi.org/10.3892/etm.2016.3730
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Abstract

Existing in Ranunculaceae Aconitum and tomato, with the chemical name 1‑phydroxybenzyl‑1,2,3,4‑tetrahy‑droisoquinoline, higenamine is widely distributed in China. Higenamine's anti‑inflammatory, antioxidant and anti‑apoptotic effects have been identified in previous studies. The present study attempted to determine the protective effect of higenamine against collagen‑induced arthritis through heme oxygenase‑1 (HO‑1) and PI3K/Akt/Nrf‑2 signaling pathways. A type II collagen (CII)‑induced arthritis (CIA) model was established and clinical arthritis scores were used to appraise the curative effect of higenamine. Inflammatory reactions, oxidative damage and caspase‑3/9 activation were detected using specific ELISA kits. In addition, western blotting was used to evaluate the expression of HO‑1, Akt and Nrf‑2 protein in CII‑induced CIA mice. In CII‑induced CIA mice, the clinical arthritis scores, inflammatory reactions, oxidation damage and caspase‑3/9 activation were increased and activated. The results demonstrated that treatment with higenamine significantly reduced the elevation of clinical arthritis scores (P<0.01), and suppressed the promotion of inflammatory reactions, oxidation damage and caspase‑3/9 activation. Furthermore, higenamine significantly increased HO‑1 protein expression (P<0.01) and upregulated the PI3K/Akt/Nrf‑2 signal pathway in CII‑induced CIA mice. Collectively, it is concluded that higenamine protects against CII‑induced CIA through the induction of HO‑1 and the upregulation of the PI3K/Akt/Nrf‑2 signaling pathway. In conclusion, higenamine may be a beneficial drug for protecting against CIA.
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1 

Bae J and Park JW: Topical delivery of leflunomide for rheumatoid arthritis treatment: Evaluation of local tissue deposition of teriflunomide and its anti-inflammatory effects in an arthritis rat model. Drug Dev Ind Pharm. 27:1–9. 2015.(Epub ahead of print).

2 

Smolen JS, Weinblatt ME, van der Heijde D, Rigby WF, van Vollenhoven R, Bingham CO III, Veenhuizen M, Gill A, Zhao F, Komocsar WJ, et al: Efficacy and safety of tabalumab, an anti-B-cell-activating factor monoclonal antibody, in patients with rheumatoid arthritis who had an inadequate response to methotrexate therapy: results from a phase III multicentre, randomised, double-blind study. Ann Rheum Dis. 74:1567–1570. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Westhovens R, Robles M, Ximenes AC, Wollenhaupt J, Durez P, Gomez-Reino J, Grassi W, Haraoui B, Shergy W, Park SH, et al: Maintenance of remission following 2 years of standard treatment then dose reduction with abatacept in patients with early rheumatoid arthritis and poor prognosis. Ann Rheum Dis. 74:564–568. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Chung KC, Kotsis SV, Fox DA, Regan M, Burke FD, Wilgis EF and Kim HM: Differences between the United States and the United Kingdom in the treatment of rheumatoid arthritis: Analyses from a hand arthroplasty trial. Clin Rheumatol. 29:363–367. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Kavanaugh A, St Clair EW, McCune WJ, Braakman T and Lipsky P: Chimeric anti-tumor necrosis factor-alpha monoclonal antibody treatment of patients with rheumatoid arthritis receiving methotrexate therapy. J Rheumatol. 27:841–850. 2000.PubMed/NCBI

6 

Richter J, Capková K, Hříbalová V, Vannucci L, Danyi I, Malý M and Fišerová A: Collagen-induced arthritis: Severity and immune response attenuation using multivalent N-acetyl glucosamine. Clin Exp Immunol. 177:121–133. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Kamada H, Goto M, Matsuura S, Takaoka Y and Nagai H: Immunopharmacological studies on collagen-induced arthritis in dark Agouti (DA) rats. Jpn J Pharmacol. 74:313–322. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Pimentel TA, Sampaio AL, D'Acquisto F, Perretti M and Oliani SM: An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse. Lab Invest. 91:33–42. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Bonamore A, Barba M, Botta B, Boffi A and Macone A: Norcoclaurine synthase: Mechanism of an enantioselective pictet-spengler catalyzing enzyme. Molecules. 15:2070–2078. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Feng S, Jiang J, Hu P, Zhang JY, Liu T, Zhao Q and Li BL: A phase I study on pharmacokinetics and pharmacodynamics of higenamine in healthy Chinese subjects. Acta Pharmacol Sin. 33:1353–1358. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Wang Z, Chen Z, Yang S, Wang Y, Yu L, Zhang B, Rao Z, Gao J and Tu S: (1)H NMR-based metabolomic analysis for identifying serum biomarkers to evaluate methotrexate treatment in patients with early rheumatoid arthritis. Exp Ther Med. 4:165–171. 2012.PubMed/NCBI

12 

Luz KR, Furtado RN, Nunes CC, Rosenfeld A, Fernandes AR and Natour J: Ultrasound-guided intra-articular injections in the wrist in patients with rheumatoid arthritis: A double-blind, randomised controlled study. Ann Rheum Dis. 67:1198–1200. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Nishiya K, Hisakawa N, Tahara K, Matsumori A, Ito H, Hashimoto K, Nakatani K and Takatori K: Additive triple DMARD combination therapy of a low dose of sulfhydryl compounds, sulfasalazine and methotrexate in the treatment of rheumatoid arthritis: A clinical trial. Acta Med Okayama. 53:275–279. 1999.PubMed/NCBI

14 

Wislowska M and Jakubicz D: Preliminary evaluation in rheumatoid arthritis activity in patients treated with TNF-alpha blocker plus methotrexate versus methotrexate or leflunomide alone. Rheumatol Int. 27:641–647. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Huang C, Wan L and Liu J: Effect of Xinfeng capsule on nuclear factor Kappa B/tumor necrosis factor alpha and transforming growth factor beta 1/Smads pathways in rats with cardiac injuries induced by adjuvant arthritis. J Tradit Chin Med. 36:92–100. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Ma Z, Piao T, Wang Y and Liu J: Astragalin inhibits IL-1beta-induced inflammatory mediators production in human osteoarthritis chondrocyte by inhibiting NF-kappaB and MAPK activation. Int Immunopharmacol. 25:83–87. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Ha YM, Kim MY, Park MK, Lee YS, Kim YM, Kim HJ, Lee JH and Chang KC: Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis. 17:463–474. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lee YS, Kang YJ, Kim HJ, Park MK, Seo HG, Lee JH, Yun-Choi HS and Chang KC: Higenamine reduces apoptotic cell death by induction of heme oxygenase-1 in rat myocardial ischemia-reperfusion injury. Apoptosis. 11:1091–1100. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Chi PL, Liu CJ, Lee IT, Chen YW, Hsiao LD and Yang CM: HO-1 induction by CO-RM2 attenuates TNF-α-induced cytosolic phospholipase A2 expression via inhibition of PKCα-dependent NADPH oxidase/ROS and NF-κB. Mediators Inflamm. 2014:2791712014. View Article : Google Scholar : PubMed/NCBI

20 

Kirino Y, Takeno M, Murakami S, Kobayashi M, Kobayashi H, Miura K, Ideguchi H, Ohno S, Ueda A and Ishigatsubo Y: Tumor necrosis factor alpha acceleration of inflammatory responses by down-regulating heme oxygenase 1 in human peripheral monocytes. Arthritis Rheum. 56:464–475. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Z, Li M, Wang Y, Wu J and Li J: Higenamine promotes M2 macrophage activation and reduces Hmgb1 production through HO-1 induction in a murine model of spinal cord injury. Int Immunopharmacol. 23:681–687. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Torres-Arzayus MI, de Mora J Font, Yuan J, Vazquez F, Bronson R, Rue M, Sellers WR and Brown M: High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell. 6:263–274. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Pareek TK, Belkadi A, Kesavapany S, Zaremba A, Loh SL, Bai L, Cohen ML, Meyer C, Liby KT, Miller RH, et al: Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. Sci Rep. 1:2012011. View Article : Google Scholar : PubMed/NCBI

24 

Ha do T, Oh J, Khoi NM, Dao TT, Dung V, Do TN, Lee SM, Jang TS, Jeong GS and Na M: In vitro and in vivo hepatoprotective effect of ganodermanontriol against t-BHP-induced oxidative stress. J Ethnopharmacol. 150:875–885. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Ugur M, Yildirim K, Kiziltunc A, Erdal A, Karatay S and Senel K: Correlation between soluble intercellular adhesion molecule 1 level and extracellular superoxide dismutase activity in rheumatoid arthritis: A possible association with disease activity. Scand J Rheumatol. 33:239–243. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Duan W, Chen J, Wu Y, Zhang Y and Xu Y: Protective effect of higenamine ameliorates collagen‑induced arthritis through heme oxygenase‑1 and PI3K/Akt/Nrf‑2 signaling pathways. Exp Ther Med 12: 3107-3112, 2016.
APA
Duan, W., Chen, J., Wu, Y., Zhang, Y., & Xu, Y. (2016). Protective effect of higenamine ameliorates collagen‑induced arthritis through heme oxygenase‑1 and PI3K/Akt/Nrf‑2 signaling pathways. Experimental and Therapeutic Medicine, 12, 3107-3112. https://doi.org/10.3892/etm.2016.3730
MLA
Duan, W., Chen, J., Wu, Y., Zhang, Y., Xu, Y."Protective effect of higenamine ameliorates collagen‑induced arthritis through heme oxygenase‑1 and PI3K/Akt/Nrf‑2 signaling pathways". Experimental and Therapeutic Medicine 12.5 (2016): 3107-3112.
Chicago
Duan, W., Chen, J., Wu, Y., Zhang, Y., Xu, Y."Protective effect of higenamine ameliorates collagen‑induced arthritis through heme oxygenase‑1 and PI3K/Akt/Nrf‑2 signaling pathways". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3107-3112. https://doi.org/10.3892/etm.2016.3730
Copy and paste a formatted citation
x
Spandidos Publications style
Duan W, Chen J, Wu Y, Zhang Y and Xu Y: Protective effect of higenamine ameliorates collagen‑induced arthritis through heme oxygenase‑1 and PI3K/Akt/Nrf‑2 signaling pathways. Exp Ther Med 12: 3107-3112, 2016.
APA
Duan, W., Chen, J., Wu, Y., Zhang, Y., & Xu, Y. (2016). Protective effect of higenamine ameliorates collagen‑induced arthritis through heme oxygenase‑1 and PI3K/Akt/Nrf‑2 signaling pathways. Experimental and Therapeutic Medicine, 12, 3107-3112. https://doi.org/10.3892/etm.2016.3730
MLA
Duan, W., Chen, J., Wu, Y., Zhang, Y., Xu, Y."Protective effect of higenamine ameliorates collagen‑induced arthritis through heme oxygenase‑1 and PI3K/Akt/Nrf‑2 signaling pathways". Experimental and Therapeutic Medicine 12.5 (2016): 3107-3112.
Chicago
Duan, W., Chen, J., Wu, Y., Zhang, Y., Xu, Y."Protective effect of higenamine ameliorates collagen‑induced arthritis through heme oxygenase‑1 and PI3K/Akt/Nrf‑2 signaling pathways". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3107-3112. https://doi.org/10.3892/etm.2016.3730
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