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Exendin‑4 antagonizes Aβ1‑42‑induced attenuation of spatial learning and memory ability

  • Authors:
    • Xiaohui Wang
    • Li Wang
    • Ruirui Jiang
    • Yunyun Xu
    • Xueling Zhao
    • Yang Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2885-2892
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    Published online on: September 21, 2016
       https://doi.org/10.3892/etm.2016.3742
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Abstract

β-amyloid protein (Aβ) accumulation in cerebral centers involved in cognition and memory is a pivotal pathological feature of Alzheimer's disease (AD). The onset process of type 2 diabetes mellitus (T2DM) has a number of similarities compared with AD. Thus, it is hypothesized that the pharmacological therapy employed for the treatment of T2DM may help to prevent and ameliorate the symptoms of AD. This study demonstrated that Exendin‑4, which is a glucagon‑like peptide‑1 analogue which is used as a therapeutic drug for T2DM, markedly antagonized Aβ fragment‑induced attenuation of spatial learning and memory ability, as indicated by a Morris water maze experiment. In addition, we investigated the potential underlying electrophysiological and molecular mechanisms. The results indicate that Exendin‑4 rescued long‑term potentiation from Aβ1‑42‑induced damage in the rat hippocampal CA1 region in vivo, and antagonized Aβ1‑42‑induced reduction of cyclic adenosine monophosphate and phosphorylated‑cAMP response element‑binding protein in rat hippocampal tissue using ELISA and western blot analysis, respectively. Thus, the results of the present study provide theoretical support for the application of Exendin‑4 for improving AD.
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View References

1 

Cummings JL: Alzheimer's disease. N Engl J Med. 351:56–67. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Hardy J and Allsop D: Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci. 12:383–388. 1991. View Article : Google Scholar : PubMed/NCBI

3 

Hoenicka J: Genes in Alzheimer's disease. Rev Neurol. 42:302–305. 2006.(In Spanish). PubMed/NCBI

4 

Bohm C, Chen F, Sevalle J, Qamar S, Dodd R, Li Y, Schmitt-Ulms G, Fraser PE and St George-Hyslop PH: Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways. Mol Cell Neurosci. 66:3–11. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Ohtake N, Saito M, Eto M and Seki K: Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex. Regul Pept 190–191. 1–11. 2014. View Article : Google Scholar

6 

Vilsbøll T, Agersø H, Krarup T and Holst JJ: Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab. 88:220–224. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Lupi R, Mancarella R, Del Guerra S, Bugliani M, Del Prato S, Boggi U, Mosca F, Filipponi F and Marchetti P: Effects of exendin-4 on islets from type 2 diabetes patients. Diabetes Obes Metab. 10:515–519. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Bassil F, Fernagut PO, Bezard E and Meissner WG: Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification? Prog Neurobiol. 118:1–18. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Calsolaro V and Edison P: Novel GLP-1 (glucagon-like peptide-1) analogues and insulin in the treatment for Alzheimer's disease and other neurodegenerative diseases. CNS Drugs. 29:1023–1039. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Wang XH, Li L, Hölscher C, Pan YF, Chen XR and Qi JS: Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats. Neuroscience. 170:1239–1248. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Wang XH, Yang W, Hölscher C, Wang ZJ, Cai HY, Li QS and Qi JS: Val8-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats. J Neurosci Res. 91:568–577. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Gengler S, McClean PL, McCurtin R, Gault VA and Hölscher C: Val (8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol Aging. 33:265–276. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Xie Z and Xu Z: General anesthetics and β-amyloid protein. Prog Neuropsychopharmacol Biol Psychiatry. 47:140–146. 2013. View Article : Google Scholar : PubMed/NCBI

14 

O'Hare E, Weldon DT, Mantyh PW, Ghilardi JR, Finke MP, Kuskowski MA, Maggio JE, Shephard RA and Cleary J: Delayed behavioral effects following intrahippocampal injection of aggregated A beta (1–42). Brain Res. 815:1–10. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Querfurth HW and LaFerla FM: Alzheimer's disease. N Engl J Med. 362:329–344. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Chiu MJ, Chen TF, Yip PK, Hua MS and Tang LY: Behavioral and psychologic symptoms in different types of dementia. J Formos Med Assoc. 105:556–562. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Sorrentino G and Bonavita V: Neurodegeneration and Alzheimer's disease: The lesson from tauopathies. Neurol Sci. 28:63–71. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Blennow K, de Leon MJ and Zetterberg H: Alzheimer's disease. Lancet. 368:387–403. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Nitta A, Fukuta T, Hasegawa T and Nabeshima T: Continuous infusion of beta-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration. Jpn J Pharmacol. 73:51–57. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Robbins TW, McAlonan G, Muir JL and Everitt BJ: Cognitive enhancers in theory and practice: Studies of the cholinergic hypothesis of cognitive deficits in Alzheimer's disease. Behav Brain Res. 83:15–23. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, et al: Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 14:837–842. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Glenner GG and Wong CW: Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 120:885–890. 1984. View Article : Google Scholar : PubMed/NCBI

23 

Guan ZZ: Cross-talk between oxidative stress and modifications of cholinergic and glutaminergic receptors in the pathogenesis of Alzheimer's disease. Acta Pharmacol Sin. 29:773–780. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Chakroborty S, Kim J, Schneider C, Jacobson C, Molgó J and Stutzmann GE: Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice. J Neurosci. 32:8341–8353. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Clementi ME, Marini S, Coletta M, Orsini F, Giardina B and Misiti F: Abeta(31–35) and Abeta(25–35) fragments of amyloid beta-protein induce cellular death through apoptotic signals: Role of the redox state of methionine-35. FEBS Lett. 579:2913–2918. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Kanai M, Matsubara E, Isoe K, Urakami K, Nakashima K, Arai H, Sasaki H, Abe K, Iwatsubo T, Kosaka T, et al: Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan. Ann Neurol. 44:17–26. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, et al: Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA. 95:6448–6453. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Bernardi A, Frozza RL, Meneghetti A, Hoppe JB, Battastini AM, Pohlmann AR, Guterres SS and Salbego CG: Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer's disease models. Int J Nanomedicine. 7:4927–4942. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Yamada K, Tanaka T, Han D, Senzaki K, Kameyama T and Nabeshima T: Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1–42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci. 11:83–90. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Kheirbakhsh R, Chinisaz M, Khodayari S, Amanpour S, Dehpour AR, Muhammadnejad A, Larijani B and Ebrahim-Habibi A: Injection of insulin amyloid fibrils in the hippocampus of male Wistar rats: Report on memory impairment and formation of amyloid plaques. Neurol Sci. 36:1411–1416. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Garcia-Osta A and Alberini CM: Amyloid beta mediates memory formation. Learn Mem. 16:267–272. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Nalivaeva NN, Beckett C, Belyaev ND and Turner AJ: Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? J Neurochem. 120:(Suppl 1). S167–S185. 2012. View Article : Google Scholar

33 

Soininen H and Hiltunen M: Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease. Expert Opin Ther Targets. 17:781–794. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Jones A, Kulozik P, Ostertag A and Herzig S: Common pathological processes and transcriptional pathways in Alzheimer's disease and type 2 diabetes. J Alzheimers Dis. 16:787–808. 2009.PubMed/NCBI

35 

Leibson CL, Rocca WA, Hanson VA, Cha R, Kokmen E, O'Brien PC and Palumbo PJ: Risk of dementia among persons with diabetes mellitus: A population-based cohort study. Am J Epidemiol. 145:301–308. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC and Butler PC: Increased risk of type 2 diabetes in Alzheimer disease. Diabetes. 53:474–481. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Alafuzoff I, Aho L, Helisalmi S, Mannermaa A and Soininen H: Beta-amyloid deposition in brains of subjects with diabetes. Neuropathol Appl Neurobiol. 35:60–68. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Accardi G, Caruso C, Colonna-Romano G, Camarda C, Monastero R and Candore G: Can Alzheimer disease be a form of type 3 diabetes? Rejuvenation Res. 15:217–221. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ and Guenette S: Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci. 100:4162–4167. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Frank-Cannon TC, Alto LT, McAlpine FE and Tansey MG: Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener. 4:472009. View Article : Google Scholar : PubMed/NCBI

41 

Kahn SE, Hull RL and Utzschneider KM: Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 444:840–846. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Nadkarni P, Chepurny OG and Holz GG: Regulation of glucose homeostasis by GLP-1. Prog Mol Biol Transl Sci. 121:23–65. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Baggio LL and Drucker DJ: Biology of incretins: GLP-1 and GIP. Gastroenterology. 132:2131–2157. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Manandhar B and Ahn JM: Glucagon-like peptide-1 (GLP-1) analogs: Recent advances, new possibilities, and therapeutic implications. J Med Chem. 58:1020–1037. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Hunter K and Hölscher C: Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci. 13:332012. View Article : Google Scholar : PubMed/NCBI

46 

Shirazi RH, Dickson SL and Skibicka KP: Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and reward. PLoS One. 8:e619652013. View Article : Google Scholar : PubMed/NCBI

47 

Kiesewetter DO, Gao H, Ma Y, Niu G, Quan Q, Guo N and Chen X: 18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinoma. Eur J Nucl Med Mol Imaging. 39:463–473. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Eakin K, Li Y, Chiang YH, Hoffer BJ, Rosenheim H, Greig NH and Miller JP: Exendin-4 ameliorates traumatic brain injury-induced cognitive impairment in rats. PLoS One. 8:e820162013. View Article : Google Scholar : PubMed/NCBI

49 

Baudry M, Zhu G, Liu Y, Wang Y, Briz V and Bi X: Multiple cellular cascades participate in long-term potentiation and in hippocampus-dependent learning. Brain Res. 1621:73–81. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Li YF, Cheng YF, Huang Y, Conti M, Wilson SP, O'Donnell JM and Zhang HT: Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. J Neurosci. 31:172–183. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Brightwell JJ, Smith CA, Neve RL and Colombo PJ: Long-term memory for place learning is facilitated by expression of cAMP response element-binding protein in the dorsal hippocampus. Learn Mem. 14:195–199. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Gonzalez GA and Montminy MR: Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell. 59:675–680. 1989. View Article : Google Scholar : PubMed/NCBI

53 

Xiong WX, Zhou GX, Wang B, Xue ZG, Wang L, Sun HC and Ge SJ: Impaired spatial learning and memory after sevoflurane-nitrous oxide anesthesia in aged rats is associated with down-regulated cAMP/CREB signaling. PLoS One. 8:e794082013. View Article : Google Scholar : PubMed/NCBI

54 

Luo J, Phan TX, Yang Y, Garelick MG and Storm DR: Increases in cAMP, MAPK activity and CREB phosphorylation during REM sleep: Implications for REM sleep and memory consolidation. J Neurosci. 33:6460–6468. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Wang C, Yang XM, Zhuo YY, Zhou H, Lin HB, Cheng YF, Xu JP and Zhang HT: The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats. Int J Neuropsychopharmacol. 15:749–766. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Wang L, Jiang R, Xu Y, Zhao X and Li Y: Exendin‑4 antagonizes Aβ1‑42‑induced attenuation of spatial learning and memory ability. Exp Ther Med 12: 2885-2892, 2016.
APA
Wang, X., Wang, L., Jiang, R., Xu, Y., Zhao, X., & Li, Y. (2016). Exendin‑4 antagonizes Aβ1‑42‑induced attenuation of spatial learning and memory ability. Experimental and Therapeutic Medicine, 12, 2885-2892. https://doi.org/10.3892/etm.2016.3742
MLA
Wang, X., Wang, L., Jiang, R., Xu, Y., Zhao, X., Li, Y."Exendin‑4 antagonizes Aβ1‑42‑induced attenuation of spatial learning and memory ability". Experimental and Therapeutic Medicine 12.5 (2016): 2885-2892.
Chicago
Wang, X., Wang, L., Jiang, R., Xu, Y., Zhao, X., Li, Y."Exendin‑4 antagonizes Aβ1‑42‑induced attenuation of spatial learning and memory ability". Experimental and Therapeutic Medicine 12, no. 5 (2016): 2885-2892. https://doi.org/10.3892/etm.2016.3742
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Wang L, Jiang R, Xu Y, Zhao X and Li Y: Exendin‑4 antagonizes Aβ1‑42‑induced attenuation of spatial learning and memory ability. Exp Ther Med 12: 2885-2892, 2016.
APA
Wang, X., Wang, L., Jiang, R., Xu, Y., Zhao, X., & Li, Y. (2016). Exendin‑4 antagonizes Aβ1‑42‑induced attenuation of spatial learning and memory ability. Experimental and Therapeutic Medicine, 12, 2885-2892. https://doi.org/10.3892/etm.2016.3742
MLA
Wang, X., Wang, L., Jiang, R., Xu, Y., Zhao, X., Li, Y."Exendin‑4 antagonizes Aβ1‑42‑induced attenuation of spatial learning and memory ability". Experimental and Therapeutic Medicine 12.5 (2016): 2885-2892.
Chicago
Wang, X., Wang, L., Jiang, R., Xu, Y., Zhao, X., Li, Y."Exendin‑4 antagonizes Aβ1‑42‑induced attenuation of spatial learning and memory ability". Experimental and Therapeutic Medicine 12, no. 5 (2016): 2885-2892. https://doi.org/10.3892/etm.2016.3742
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