Clinical effects of joint application of β-sodium aescinate and mannitol in treating early swelling after upper limb trauma surgery

Wang,Bin; Yang,Ruixiang; Ju,Qing; Liu,Shaofeng; Zhang,Yongchun; Ma,Yong

doi:10.3892/etm.2016.3743

November-2016 Volume 12 Issue 5

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November-2016 Volume 12 Issue 5

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Article Open Access

Clinical effects of joint application of β-sodium aescinate and mannitol in treating early swelling after upper limb trauma surgery

Authors:
- Bin Wang
- Ruixiang Yang
- Qing Ju
- Shaofeng Liu
- Yongchun Zhang
- Yong Ma
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Affiliations: Department of Orthopeadic Surgery, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China, Department of Hospital Infection‑Control, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China, Patient Service Center, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China

Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 3320-3322
|
Published online on: September 22, 2016

https://doi.org/10.3892/etm.2016.3743
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Abstract

The aim of the present study was to examine the clinical merits of joint application of β‑sodium aescinate and mannitol for the treatment of early swelling of upper limb trauma after surgery. We verified whether the expression of serum aquaporin 1 (AQP-1) was involved in swelling mechanism. A total of 102 patients with swelling after upper limb trauma surgery were enrolled into the study and divided randomly into 3 groups (n=34 cases per group). Group A was treated with β‑sodium aescinate; group B was treated with with mannitol and group C was treated with both β‑sodium aescinate and mannitol. The expression level of AQP‑1, and clinical effects and complications before and after treatment were compared§. The time of swelling subsidence in group C was significantly shorter than that of the other two groups and differences were statistically significant (P<0.05). The recovery ratio and total efficiency in group C were significantly higher than those in other two groups and differences were statistically significant (P<0.05). Three and seven days after treatment, the AQP‑1 levels in group A and group C were decreased and AQP‑1 level decreased further with time. Differences of comparison within groups were statistically significant (P<0.05), although the differences of comparison between the groups showed no statistical significance (P>0.05). We also compared the AQP‑1 level in group B before and after treatment, and the differences were not statistically significant (P>0.05). When the complication incidence in the 3 groups was compared, no statistical significance was detected (P>0.05). We concluded that the joint use of β‑sodium aescinate and mannitol in treating early swelling after upper limb trauma surgery produced satisfactory outcomes. This might be related to reduction of the AQP-1 level.

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1	Via AG, Oliva F, Spoliti M and Maffulli N: Acute compartment syndrome. Muscles Ligaments Tendons J. 5:18–22. 2015.PubMed/NCBI
2	Lin SY, Tang SC, Tsai LK, Yeh SJ, Shen LJ, Wu FL and Jeng JS: Incidence and risk factors for acute kidney injury following mannitol infusion in patients with acute stroke: A retrospective cohort study. Medicine (Baltimore). 94:e20322015. View Article : Google Scholar : PubMed/NCBI
3	Rai R, Ahuja CK, Agrawal S, Kalra N, Duseja A, Khandelwal N, Chawla Y and Dhiman RK: Reversal of low-grade cerebral edema after lactulose/rifaximin therapy in patients with cirrhosis and minimal hepatic encephalopathy. Clin Transl Gastroenterol. 6:e1112015. View Article : Google Scholar : PubMed/NCBI
4	Thomsen G, Bezdjian L, Rodriguez L and Hopkins RO: Clinical outcomes of a furosemide infusion protocol in edematous patients in the intensive care unit. Crit Care Nurse. 32:25–34. 2012. View Article : Google Scholar : PubMed/NCBI
5	Zhang Z, Cao G, Sha L, Wang D and Liu M: The efficacy of sodium aescinate on cutaneous wound healing in diabetic rats. Inflammation. 38:1942–1948. 2015. View Article : Google Scholar : PubMed/NCBI
6	Kang J, Gong P, Ren YB, Gao DN and Ding QL: Effect of β-sodium aescinate on hypoxia-inducible factor-1α expression in rat brain cortex after cardiopulmonary resuscitation. World J Emerg Med. 4:63–68. 2013. View Article : Google Scholar : PubMed/NCBI
7	Fu CG: Treatment for crush syndrome of extremities with antioxidants. Zhongguo Gu Shang. 21:109–110. 2008.(In Chinese). PubMed/NCBI
8	Kafa N, Citaker S, Omeroglu S, Peker T, Coskun N and Diker S: Effects of kinesiologic taping on epidermal-dermal distance, pain, edema and inflammation after experimentally induced soft tissue trauma. Physiother Theory Pract. 31:556–561. 2015. View Article : Google Scholar : PubMed/NCBI
9	Nomani AZ, Nabi Z, Rashid H, Janjua J, Nomani H, Majeed A, Chaudry SR and Mazhar AS: Osmotic nephrosis with mannitol: Review article. Ren Fail. 36:1169–1176. 2014. View Article : Google Scholar : PubMed/NCBI
10	Lang W: Studies on the percutaneous absorption of 3H-aescin in pigs. Res Exp Med (Berl). 169:175–187. 1977. View Article : Google Scholar : PubMed/NCBI
11	Rothkopf M, Vogel G, Lang W and Leng E: Animal experiments on the question of the renal toleration of the horse chestnut saponin aescin. Arzneimittelforschung. 27:598–605. 1977.(In German). PubMed/NCBI
12	Soltani Z, Khaksari M, Shahrokhi N, Mohammadi G, Mofid B, Vaziri A and Amiresmaili S: Effect of estrogen and/or progesterone administration on traumatic brain injury-caused brain edema: The changes of aquaporin-4 and interleukin-6. J Physiol Biochem. 72:33–44. 2016. View Article : Google Scholar : PubMed/NCBI
13	Jiang YX, Dai ZL, Zhang XP, Zhao W, Huang Q and Gao LK: Dexmedetomidine alleviates pulmonary edema by upregulating AQP1 and AQP5 expression in rats with acute lung injury induced by lipopolysaccharide. J Huazhong Univ Sci Technolog Med Sci. 35:684–688. 2015. View Article : Google Scholar : PubMed/NCBI
14	Li L, Weng Z, Yao C, Song Y and Ma T: Aquaporin-1 deficiency protects against myocardial infarction by reducing both edema and apoptosis in mice. Sci Rep. 5:138072015. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical effects of joint application of β-sodium aescinate and mannitol in treating early swelling after upper limb trauma surgery

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