Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2016 Volume 12 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2016 Volume 12 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head

  • Authors:
    • Hongwei Min
    • Feng Xu
    • Rui Gu
    • Xinzuo Han
    • Anqing Wang
    • Kemin Liu
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation, Capital Medical University, Beijing 100068, P.R. China
  • Pages: 3347-3352
    |
    Published online on: October 11, 2016
       https://doi.org/10.3892/etm.2016.3787
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to explore the potential diagnostic role of diffusion tensor magnetic resonance imaging (DTI) in the early stage of modified corticosteroid-induced osteonecrosis of the femoral head (ONFH). A total of 20 beagles were randomly classified (1:1) into either an experimental group (LM), which were intramuscularly injected with lipopolysaccharide (LPS) and methylprednisolone (MPS) on three consecutive days, or control (CON) group, which were injected with saline. Magnetic resonance imaging (MRI) and DTI were performed at pre‑induction and 8 and 12 weeks post‑induction. Apparent diffusion coefficient (ADC) values in the range of interest in the femoral head were quantified using DTI. Proximal femora were examined for ONFH at 8 and 12 weeks. The results demonstrated that ONFH developed in four beagles at 8 weeks and in six beagles at 12 weeks, whereas no ONFH was detected in the CON group. No abnormalities were detected by MRI and DTI, and no mortality occurred. In beagles with ONFH in the LM group, the ADC values were 4.7±0.2x10‑4 and 4.8±0.3x10‑4 mm2/sec at 8 and 12 weeks, respectively, which were significantly increased compared with the CON group (2.5±0.3x10‑4 and 2.4±0.3x10‑4 mm2, respectively) and the LM group without ONFH (2.6±0.4x10‑4 and 2.4±0.3x10‑4 mm2, respectively) (P<0.05). The results of the present study indicated that intramuscular injection of LPS and MPS may lead to early‑stage ONFH in beagles. As such, the detection of locally elevated ADC values in the femoral head may aid in the early diagnosis of ONFH.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Petrigliano FA and Lieberman JR: Osteonecrosis of the hip: Novel approach to evaluation and treatment. Clin Orthop Relat Res. 465:53–62. 2007.PubMed/NCBI

2 

Mankin HJ: Nontraumatic necrosis of bone (osteonecrosis). N Engl J Med. 326:1473–1479. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Chandler FA: Coronary disease of the hip. J Int Coll Surg. 1:34–36. 1948.

4 

Ficat RP: Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment. J Bone Joint Surg Br. 67:3–9. 1985.PubMed/NCBI

5 

Chen XC, Weng J, Chen XQ, Du JZ, Zhu MP, Pan YQ and Liu M: Relationships among magnetic resonance imaging, histological findings, and IGF-I in steroid-induced osteonecrosis of the femoral head in rabbits. J Zhejiang Univ Sci B. 9:739–746. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Berg BC Vande, Gilon R, Malghem J, Lecouvet F, Depresseux G and Houssiau FA: Correlation between baseline femoral neck marrow status and the development of femoral head osteonecrosis in corticosteroid-treated patients: A longitudinal study by MR imaging. Eur J Radiol. 58:444–449. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Schmitt-Sody M, Kirchhoff C, Mayer W, Goebel M and Jansson V: Avascular necrosis of the femoral head: Inter- and intraobserver variations of Ficat and ARCO classifications. Int Orthop. 32:283–287. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Wang C, Peng J and Lu S: Summary of the various treatments for osteonecrosis of the femoral head by mechanism: A review. Exp Ther Med. 8:700–706. 2014.PubMed/NCBI

9 

Dickerson BC: Advances in functional magnetic resonance imaging: Technology and clinical applications. Neurotherapeutics. 4:360–370. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Bhutani M, Turkbey B, Tan E, Korde N, Kwok M, Manasanch EE, Tageja N, Mailankody S, Roschewski M, Mulquin M, et al: Bone marrow abnormalities and early bone lesions in multiple myeloma and its precursor disease: A prospective study using functional and morphologic imaging. Leuk Lymphoma. 57:1114–1121. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Sangeetha R, Uma K and Chandavarkar V: Comparison of routine decalcification methods with microwave decalcification of bone and teeth. J Oral Maxillofac Pathol. 17:386–391. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Wada M, Kumagai K, Murata M, S-Yamashita Y and Shindo H: Warfarin reduces the incidence of osteonecrosis of the femoral head in spontaneously hypertensive rats. J Orthop Sci. 9:585–590. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Arlet J: Atraumatic necrosis of the femoral head: General reportBone Circulation and Vascularization in Normal and Pathological Conditions. Schoutens A, Arlet J, Gardeniers JWM and Hughes SPF: Springer US; New York, NY: pp. 235–240. 1993, View Article : Google Scholar

14 

Mont MA, Jones JC and Hungerford DS: Nontraumatic osteonecrosis of the femoral head: Ten years later. J Bone Joint Surg Am. 88:1117–1132. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Chan KL and Mok CC: Glucocorticoid-induced avascular bone necrosis: Diagnosis and management. Open Orthop J. 6:449–457. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Cress RL: Osteonecrosis of bone. Current concept as to etiology and pathogenesis. Clin Orthop Relat Res. 208:30–39. 1986.PubMed/NCBI

17 

Glimcher MJ and Kenzora JE: The biology of osteonecrosis of the human femoral head and its clinical implications. III. Discussion of the etiology and genesis of the pathological sequelae; commments on treatment. Clin Orthop Relat Res. 140:273–312. 1979.PubMed/NCBI

18 

Sheng HH, Zhang GG, Cheung WH, Chan CW, Wang YX, Lee KM, Wang HF, Leung KS and Qin LL: Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development. J Orthop Surg Res. 2:152007. View Article : Google Scholar : PubMed/NCBI

19 

Zhang G, Sheng H, He YX, Xie XH, Wang YX, Lee KM, Yeung KW, Li ZR, He W, Griffith JF, et al: Continuous occurrence of both insufficient neovascularization and elevated vascular permeability in rabbit proximal femur during inadequate repair of steroid-associated osteonecrotic lesions. Arthritis Rheum. 60:2966–2977. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Zhang G, Qin L, Sheng H, Yeung KW, Yeung HY, Cheung WH, Griffith J, Chan CW, Lee KM and Leung KS: Epimedium-derived phytoestrogen exert beneficial effect on preventing steroid-associated osteonecrosis in rabbits with inhibition of both thrombosis and lipid-deposition. Bone. 40:685–692. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Wu X, Yang S, Duan D, Zhang Y and Wang J: Experimental osteonecrosis induced by a combination of low-dose lipopolysaccharide and high-dose methylprednisolone in rabbits. Joint Bone Spine. 75:573–578. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Okazaki S, Nishitani Y, Nagoya S, Kaya M, Yamashita T and Matsumoto H: Femoral head osteonecrosis can be caused by disruption of the systemic immune response via the toll-like receptor 4 signalling pathway. Rheumatology (Oxford). 48:227–232. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Sun Y, Feng Y and Zhang C: The effect of bone marrow mononuclear cells on vascularization and bone regeneration in steroid-induced osteonecrosis of the femoral head. Joint Bone Spine. 76:685–690. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Brozma JP: Schwartzman reaction. Semin Thromb Hemost. 16:326–332. 1990. View Article : Google Scholar : PubMed/NCBI

25 

Scholzen TE, Sunderkotter C, Kalden DH, Brzoska T, Fastrich M, Fisbeck T, Armstrong CA, Ansel JC and Luger TA: Alpha-melanocyte stimulating hormone prevents lipopolysaccharide-induced vasculitis by down-regulating endothelial cell adhesion molecule expression. Endocrinology. 144:360–370. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Milne S and King GG: Advanced imaging in COPD: Insights into pulmonary pathophysiology. J Thorac Dis. 6:1570–1585. 2014.PubMed/NCBI

27 

Plenk H Jr, Gstettner M, Grosschmidt K, Breitenseher M, Urban M and Hofmann S: Magnetic resonance imaging and histology of repair in femoral head osteonecrosis. Clin Orthop Relat Res. 386:42–53. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Fordyce MJ and Solomon L: Early detection of avascular necrosis of the femoral head by MRI. J Bone Joint Surg Br. 75:365–367. 1993.PubMed/NCBI

29 

Hauzeur JP, Sintzoff S Jr, Applelboom T, De Maertelaer V, Bentin J and Pasteels JL: Relationship between magnetic resonance imaging and histologic findings by bone biopsy in nontraumatic osteonecrosis of the femoral head. J Rheumatol. 19:385–392. 1992.PubMed/NCBI

30 

Beltran J, Herman LJ, Burk JM, Zuelzer WA, Clark RN, Lucas JG, Weiss LD and Yang A: Femoral head avascular necrosis: MR imaging with clinical-pathologic and radionuclide correlation. Radiology. 166:215–220. 1988. View Article : Google Scholar : PubMed/NCBI

31 

Hou CH, Shih TT, Liu CY, Li YD and Enright T: Proton MR spectroscopy of the femoral head-evaluation of patients at risk for avascular necrosis. J Magn Reson Imaging. 24:409–417. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Du J, Lu A, Dempsey M, Herring JA and Kim HK: MR perfusion index as a quantitative method of evaluating epiphyseal perfusion in legg-calve-perthes disease and correlation with short-term radiographic outcome: A preliminary study. J Pediatr Orthop. 33:707–713. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Yoo WJ, Kim YJ, Menezes NM, Cheon JE and Jaramillo D: Diffusion-weighted MRI reveals epiphyseal and metaphyseal abnormalities in legg-calvé-perthes disease: A pilot study. Clin Orthop Relat Res. 469:2881–2888. 2011. View Article : Google Scholar : PubMed/NCBI

34 

de Visser SK, Crawford RW and Pope JM: Structural adaptations in compressed articular cartilage measured by diffusion tensor imaging. Osteoarthritis Cartilage. 16:83–89. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Hagmann P, Thiran JP, Jonasson L, Vandergheynst P, Clarke S, Maeder P and Meuli R: DTI mapping of human brain connectivity: Statistical fibre tracking and virtual dissection. Neuroimage. 19:545–554. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Chen J, Liu W, Zhang H, Lacy L, Yang X, Song SK, Wickline SA and Yu X: Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: Quantification with diffusion tensor MRI. Am J Physiol Heart Circ Physiol. 289:H1898–H1907. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Raya JG, Horng A, Dietrich O, Krasnokutsky S, Beltran LS, Storey P, Reiser MF, Recht MP, Sodickson DK and Glaser C: Articular cartilage: In vivo diffusion-tensor imaging. Radiology. 262:550–559. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Provenzale JM, Isaacson J, Chen S, Stinnett S and Liu C: Correlation of apparent diffusion coefficient and fractional anisotropy values in the developing infant brain. AJR Am J Roentgenol. 195:W456–62. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Min H, Xu F, Gu R, Han X, Wang A and Liu K: Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head. Exp Ther Med 12: 3347-3352, 2016.
APA
Min, H., Xu, F., Gu, R., Han, X., Wang, A., & Liu, K. (2016). Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head. Experimental and Therapeutic Medicine, 12, 3347-3352. https://doi.org/10.3892/etm.2016.3787
MLA
Min, H., Xu, F., Gu, R., Han, X., Wang, A., Liu, K."Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head". Experimental and Therapeutic Medicine 12.5 (2016): 3347-3352.
Chicago
Min, H., Xu, F., Gu, R., Han, X., Wang, A., Liu, K."Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3347-3352. https://doi.org/10.3892/etm.2016.3787
Copy and paste a formatted citation
x
Spandidos Publications style
Min H, Xu F, Gu R, Han X, Wang A and Liu K: Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head. Exp Ther Med 12: 3347-3352, 2016.
APA
Min, H., Xu, F., Gu, R., Han, X., Wang, A., & Liu, K. (2016). Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head. Experimental and Therapeutic Medicine, 12, 3347-3352. https://doi.org/10.3892/etm.2016.3787
MLA
Min, H., Xu, F., Gu, R., Han, X., Wang, A., Liu, K."Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head". Experimental and Therapeutic Medicine 12.5 (2016): 3347-3352.
Chicago
Min, H., Xu, F., Gu, R., Han, X., Wang, A., Liu, K."Potential diagnostic role of diffusion tensor imaging in early-stage osteonecrosis of the femoral head". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3347-3352. https://doi.org/10.3892/etm.2016.3787
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team