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Effects of forced swimming stress on thyroid function, pituitary thyroid‑stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats

  • Authors:
    • Qiuyan Sun
    • Aihua Liu
    • Yanan Ma
    • Anyi Wang
    • Xinhong Guo
    • Weiping Teng
    • Yaqiu Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3167-3174
    |
    Published online on: October 11, 2016
       https://doi.org/10.3892/etm.2016.3790
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Abstract

In order to study the impact that is imposed on the hypothalamic‑pituitary‑thyroid (HPT) axis of adrenalectomy male Wistar rats by stress caused by swimming, the blood level of triiodothyronine (T3), thyroxine (T4) and thyroid‑stimulating hormone (TSH), the expression of TSHβ mRNA at the pituitary and thyrotropin releasing hormone (TRH) expression at the paraventricular nucleus (PVN) were measured. A total of 50 male Wistar rats of 6‑8 weeks of age and with an average weight of 190‑210 grams were randomly divided into the following two groups: The surgical (without adrenal glands) and non‑surgical (adrenalectomy) group. These two groups were then divided into the following five groups, according to the time delay of sacrifice following forced swim (10 min, 2 h, 12 h and 24 h) and control (not subjected to swimming) groups. A bilateral adrenalectomy animal model was established. Serum TSH in the blood was measurement by chemiluminescent immunoassay, and cerebrum tissue were excised for the measurement of TRH expression using an immunohistochemistry assay. In addition, pituitaries were excised for the extraction of total RNA. Finally, reverse transcription‑quantitative polymerase chain reaction was performed for quantitation of TSHβ. Following swimming, the serum T3, T4 and TSH, the TSHβ mRNA expression levels in the pituitary and the TRH expression in the PVN of the surgical group were gradually increased. In the non‑surgical group, no significant differences were observed in the serum T3, T4 and TSH levels compared with the control group. The TSHβ mRNA expression at the pituitary showed a similar result. Furthermore, the TRH expression at PVN was gradually increased and stress from swimming could increase the blood T4, T3 and TSH levels, TSHβ mRNA expression at the pituitary and TRH expression at the PVN in adrenalectomy Wistar rats. Moreover, the index in the surgical group changed significantly compared with the non‑surgical group. In conclusion, the results suggest that there is a positive correlation between stress from forced swimming and the variation of the HPT axis.
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1 

Haugen BR: Drugs that suppress TSH or cause central hypothyroidism. Best Pract Res Clin Endocrinol Metab. 23:793–800. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeöld A and Bianco AC: Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev. 29:898–938. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Wrutniak-Cabello C, Casas F and Cabello G: Thyroid hormone action in mitochondria. J Mol Endocrinol. 26:67–77. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Servatius RJ, Natelson BH, Moldow R, Pogach L, Brennan FX and Ottenweller JE: Persistent neuroendocrine changes in multiple hormonal axes after a single or repeated stressor exposures. Stress. 3:263–274. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Helmreich DL, Crouch M, Dorr NP and Parfitt DB: Peripheral triiodothyronine (T(3)) levels during escapable and inescapable footshock. Physiol Behav. 87:114–119. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Kilburn-Watt E, Banati RB and Keay KA: Altered thyroid hormones and behavioural change in a sub-population of rat following chronic constriction injury. J Neuroendocrinol. 22:960–970. 2010.PubMed/NCBI

7 

Sabban EL and Kvetnanský R: Stress-triggered activation of gene expression in catecholaminergic systems: Dynamics of transcriptional events. Trends Neurosci. 24:91–98. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Han Mei-Jun and Ma Dian-Li: Change of immune function in psychological stress. Zhong Guo Lin Chuang Kang Fu. 10:189–192. 2006.(In Chinese).

9 

Hölscher C: Stress impairs performance in spatial water maze learning tasks. Behav Brain Res. 100:225–235. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Mebis L and Van den Berghe G: Thyroid axis function and dysfunction in critical illness. Best Pract Res Clin Endocrinol Metab. 25:745–757. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Iervasi G, Pingitore A, Landi P, Raciti M, Ripoli A, Scarlattini M, L'Abbate A and Donato L: Low-T3 syndrome: A strong prognostic predictor of death in patients with heart disease. Circulation. 107:708–713. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Shelton RC: The use of antidepressants in novel combination therapies. J Clin Psychiatry. 64(Suppl 2): S14–S18. 2003.

13 

Armario A, Castellanos JM and Balasch J: Effect of acute and chronic psychogenic stress on corticoadrenal and pituitary-thyroid hormones in male rats. Horm Res. 20:241–245. 1984. View Article : Google Scholar : PubMed/NCBI

14 

Turakulov YKh, Burikhanov RB, Patkhitdinov PP and Myslitskaya AI: Influence of immobilization stress on the levels of thyroid hormones. Neurosci Behav Physiol. 24:462–464. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Cizza G, Brady LS, Esclapes ME, Blackman MR, Gold PW and Chrousos GP: Age and gender influence basal and stress-modulated hypothalamic-pituitary-thyroidal function in Fischer 344/N rats. Neuroendocrinology. 64:440–448. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Kondo K, Harbuz MS, Levy A and Lightman SL: Inhibition of the hypothalamic-pituitary-thyroid axis in response to lipopolysaccharide is independent of changes in circulating corticosteroids. Neuroimmunomodulation. 4:188–194. 1997.PubMed/NCBI

17 

Helmreich DL and Tylee D: Thyroid hormone regulation by stress and behavioral differences in adult male rats. Horm Behav. 60:284–291. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Fliers E, Korbonits M and Romijn JA: Hypothalamic-pituitary hormones during critical illness: A dynamic neuroendocrine response. Clin Neuroendocrinol. 124:115–126. 2014.

19 

Légrádi G, Emerson CH, Ahima RS, Flier JS and Lechan RM: Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology. 138:2569–2576. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Roelfsema F, Pereira AM, Biermasz NR, Frolich M, Keenan DM, Veldhuis JD and Romijn JA: Diminished and irregular TSH secretion with delayed acrophase in patients with Cushing's syndrome. Eur J Endocrinol. 161:695–703. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Hangaard J, Andersen M, Grodum E, Koldkjaer O and Hagen C: Pulsatile thyrotropin secretion in patients with Addison's disease during variable glucocorticoid therapy. J Clin Endocrinol Metab. 81:2502–2507. 1996. View Article : Google Scholar : PubMed/NCBI

22 

Bruhn TO, McFarlane MB, Deckey JE and Jackson IM: Analysis of pulsatile secretion of thyrotropin and growth hormone in the hypothyroid rat. Endocrinology. 131:2615–2621. 1992. View Article : Google Scholar : PubMed/NCBI

23 

Su Y, van der Spek R, Foppen R, Kwakkel J, Fliers E and Kalsbeek A: Effects of adrenalectomy on daily gene expression rhythms in the rat suprachiasmatic and paraventricular hypothalamic nuclei and in white adipose tissue. Chronobiol Int. 32:211–224. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Silva EJ, Vendramini V, Restelli A, Bertolla RP, Kempinas WG and Avellar MC: Impact of adrenalectomy and dexamethasone treatment on testicular morphology and sperm parameters in rats: insights into the adrenal control of male reproduction. Andrology. 2:835–846. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Matos-Santos A, Nobre EL, Costa JG, Nogueira PJ, Macedo A, Galvão-Teles A and de Castro JJ: Relationship between the number and impact of stressful life events and the onset of Graves' disease and toxic nodular goitre. Clin Endocrinol. 55:15–19. 2001. View Article : Google Scholar

26 

Slavich GM and Irwin MR: From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 140:774–815. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Jiang YQ, Kawashima H, Iwasaki Y, Uchida K, Sugimoto K and Itoi K: Differential effects of forced swim-stress on the corticotrophin-releasing hormone and vasopressin gene transcription in the parvocellular division of the paraventricular nucleus of rat hypothalamus. Neurosci Lett. 358:201–204. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Haugen BR: Drugs that suppress TSH or cause central hypothyroidism. Best Pract Res Clin Endocrinol Metab. 23:793–800. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Sui L, Ren WW and Li BM: Administration of thyroid hormone increases reelin and brain-derived neurotrophic factor expression in rat hippocampus in vivo. Brain Res. 1313:9–24. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Kong WM, Martin NM, Smith KL, Gardiner JV, Connoley IP, Stephens DA, Dhillo WS, Ghatei MA, Small CJ and Bloom SR: Triiodothyronine stimulates food intake via the hypothalamic ventromedial nucleus independent of changes in energy expenditure. Endocrinology. 145:5252–5258. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Caria MA, Dratman MB, Kow LM, Mameli O and Pavlides C: Thyroid hormone action: Nongenomic modulation of neuronal excitability in the hippocampus. J Neuroendocrinol. 21:98–107. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Davis PJ, Leonard JL and Davis FB: Mechanisms of nongenomic actions of thyroid hormone. Front Neuroendocrinol. 29:211–218. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Guo TY, Liu LJ, Xu L, Zhang JC, Li SX, Chen C, He LG, Chen YM, Yang HD, Lu L and Hashimoto K: Alterations of the daily rhythms of HPT axis induced by chronic unpredicted mild stress in rats. Endocrine. 48:1–7. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Helmreich DL, Parfitt DB, Lu XY, Akil H and Watson SJ: Relation between the hypothalamic-pituitary-thyroid (HPT) axis and the hypothalamic-pituitary-adrenal (HPA) axis during repeated stress. Neuroendocrinology. 81:183–192. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Kakucksa I, Qi Y and Lechan RM: Changes in adrenal status affect hypothalamic thyrotropin-releasing hormone gene expression in parallel with corticotropin-releasing hormone. Endocrinology. 136:2795–2802. 1995. View Article : Google Scholar : PubMed/NCBI

36 

Bianco AC, Nunes MT, Hell NS and Maciel RM: The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3′-triiodothyronine generation in rats. Endocrinology. 120:1033–1038. 1987. View Article : Google Scholar : PubMed/NCBI

37 

Luo LG, Bruhn T and Jackson IM: Glucocorticoids stimulate thyrotropin-releasing hormone gene expression in cultured hypothalamic neurons. Endocrinology. 136:4945–4950. 1995. View Article : Google Scholar : PubMed/NCBI

38 

Lechan RM and Fekete C: The TRH neuron: A hypothalamic integrator of energy metabolism. Prog Brain Res. 153:209–235. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Herman JP and Cullinan WE: Neurocircuitry of stress: Central control of the hypothalamic-adrenocortical axis. Trends Neurosci. 20:78–84. 1997. View Article : Google Scholar : PubMed/NCBI

40 

Perello M, Friedman T, Paez-Espinosa V, Shen X, Stuart RC and Nillni EA: Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Endocrinology. 147:2705–2716. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Heuer H, Schäfer MK and Bauer K: The thyrotropin-releasing hormone-degrading ectoenzyme: The third element of the thyrotropin-releasing hormone-signaling system. Thyroid. 8:915–920. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Sánchez E, Vargas MA, Singru PS, Pascual I, Romero F, Fekete C, Charli JL and Lechan RM: Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence. Endocrinology. 150:2283–2291. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Selye H: A syndrome produced by diverse nocuous agents. Nature. 10:230–231. 1998.

44 

Wang J and Zhang J: The effect of cold stress on the HPT axis of chicken. Zhong Guo Chu Mu Za Zhi. 44:39–42. 2008.(In Chinese).

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Copy and paste a formatted citation
Spandidos Publications style
Sun Q, Liu A, Ma Y, Wang A, Guo X, Teng W and Jiang Y: Effects of forced swimming stress on thyroid function, pituitary thyroid‑stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats. Exp Ther Med 12: 3167-3174, 2016.
APA
Sun, Q., Liu, A., Ma, Y., Wang, A., Guo, X., Teng, W., & Jiang, Y. (2016). Effects of forced swimming stress on thyroid function, pituitary thyroid‑stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats. Experimental and Therapeutic Medicine, 12, 3167-3174. https://doi.org/10.3892/etm.2016.3790
MLA
Sun, Q., Liu, A., Ma, Y., Wang, A., Guo, X., Teng, W., Jiang, Y."Effects of forced swimming stress on thyroid function, pituitary thyroid‑stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats". Experimental and Therapeutic Medicine 12.5 (2016): 3167-3174.
Chicago
Sun, Q., Liu, A., Ma, Y., Wang, A., Guo, X., Teng, W., Jiang, Y."Effects of forced swimming stress on thyroid function, pituitary thyroid‑stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3167-3174. https://doi.org/10.3892/etm.2016.3790
Copy and paste a formatted citation
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Spandidos Publications style
Sun Q, Liu A, Ma Y, Wang A, Guo X, Teng W and Jiang Y: Effects of forced swimming stress on thyroid function, pituitary thyroid‑stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats. Exp Ther Med 12: 3167-3174, 2016.
APA
Sun, Q., Liu, A., Ma, Y., Wang, A., Guo, X., Teng, W., & Jiang, Y. (2016). Effects of forced swimming stress on thyroid function, pituitary thyroid‑stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats. Experimental and Therapeutic Medicine, 12, 3167-3174. https://doi.org/10.3892/etm.2016.3790
MLA
Sun, Q., Liu, A., Ma, Y., Wang, A., Guo, X., Teng, W., Jiang, Y."Effects of forced swimming stress on thyroid function, pituitary thyroid‑stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats". Experimental and Therapeutic Medicine 12.5 (2016): 3167-3174.
Chicago
Sun, Q., Liu, A., Ma, Y., Wang, A., Guo, X., Teng, W., Jiang, Y."Effects of forced swimming stress on thyroid function, pituitary thyroid‑stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3167-3174. https://doi.org/10.3892/etm.2016.3790
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