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Article

Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion

  • Authors:
    • Yan‑Feng Pan
    • Yan Zheng
    • Tao Qin
    • Lei Feng
    • Qian Zhang
    • Xiao‑Gong Ping
    • Yan‑Ting Pan
    • Xiao‑Ping Wang
    • Li Bai
    • Hua‑Hua Li
  • View Affiliations / Copyright

    Affiliations: Department of Infection, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China, Department of Hepatobiliary Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China, Department of Infection, The First Hospital Affiliated to Henan University, Kaifeng, Henan 475000, P.R. China, Department of Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
  • Pages: 3476-3484
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    Published online on: October 11, 2016
       https://doi.org/10.3892/etm.2016.3792
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Abstract

The majority of patients with hepatitis C virus (HCV) in China were infected via blood transfusion prior to the year 1996. In this systematic retrospective cohort study, disease progression in 804 consecutive patients with transfusion‑acquired HCV is investigated. In addition, the occurrence of compensated cirrhosis, decompensated cirrhosis and hepatocellular carcinoma (HCC) is analyzed among these patients, along with the risk factors for disease progression. Patients with cirrhosis or HCC were classified as the serious development group (SD group) and the remaining patients with chronic hepatitis were classified as the hepatitis group (H group). Significant differences were found between the two groups in age at the time of infection, duration of infection and age at the time of observation. SD group patients were significantly older at the time of transfusion (33.73 vs. 23.56 years; P<0.001), with a significantly longer mean duration of HCV infection (21.88 vs. 21.15 years; P=0.029) compared with that in the H group. Male gender and age at the time of transfusion were significant risk factors for HCC (OR=2.48, P=0.031 and OR=1.07, P=0.002, respectively). Age was a significant risk factor for disease progression in older Chinese patients with transfusion‑acquired HCV, and there were significant differences in the prevalence of compensated cirrhosis, decompensated cirrhosis and HCC between the age groups (P<0.001), suggesting that more patients with HCV may develop cirrhosis or HCC in their third and fourth decades of infection. Results of the present study will be helpful for predicting disease progression in Chinese patients with HCV infected via blood transfusion.
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1 

Alter MJ: Epidemiology of hepatitis C virus infection. World J Gastroenterol. 13:2436–2441. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Irshad M, Mankotia DS and Irshad K: An insight into the diagnosis and pathogenesis of hepatitis C virus infection. World J Gastroenterol. 19:7896–7909. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Lauer GM and Walker BD: Hepatitis C virus infection. N Engl J Med. 345:41–52. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Pybus OG, Barnes E, Taggart R, Lemey P, Markov PV, Rasachak B, Syhavong B, Phetsouvanah R, Sheridan I, Humphreys IS, et al: Genetic history of hepatitis C virus in East Asia. J Virol. 83:1071–1082. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Xia GLLC, Cao HL, Bi SL, Zhan MY, Su CA, Nan JH and Qi XQ: Prevalence of hepatitis B and C virus infections in the general Chinese population. Results from a nationwide cross-sectional seroepidemiologic study of hepatitis A, B, C, D and E virus infections in China. Int Hepatol Commun. 5:62–73. 1996. View Article : Google Scholar

6 

Kato N, Yokosuka O, Hosoda K, Ito Y, Ohto M and Omata M: Detection of hepatitis C virus RNA in acute non-A, non-B hepatitis as an early diagnostic tool. Biochem Biophys Res Commun. 192:800–807. 1993. View Article : Google Scholar : PubMed/NCBI

7 

Yuki N, Hayashi N, Ohkawa K, Hagiwara H, Oshita M, Katayama K, Sasaki Y, Kasahara A, Fusamoto H and Kamada T: The significance of immunoglobulin M antibody response to hepatitis C virus core protein in patients with chronic hepatitis C. Hepatology. 22:402–406. 1995. View Article : Google Scholar : PubMed/NCBI

8 

TCLDA: IDaPDB, . Prevention and treatment of hepatitis C. Chin J Hepatol. 12:194–198. 2004.

9 

Ding JYX and Zhang HM: Analysis on testing of elderly patients with hepatitis C. Lab Med Clin. 17:1474–1475. 2009.

10 

Wiese M, Fischer J, Lobermann M, Göbel U, Grüngreiff K, Güthoff W, Kullig U, Richter F, Schiefke I, Tenckhoff H, et al: East German HCV Study Group: Evaluation of liver disease progression in the German hepatitis C virus (1b)-contaminated anti-D cohort at 35 years after infection. Hepatology. 59:49–57. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Zein NN: Clinical significance of hepatitis C virus genotypes. Clin Microbiol Rev. 13:223–235. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Messina JP, Humphreys I, Flaxman A, Brown A, Cooke GS, Pybus OG and Barnes E: Global distribution and prevalence of hepatitis C virus genotypes. Hepatology. 61:77–87. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Utama A, Budiarto BR, Monasari D, Octavia TI, Chandra IS, Gani RA, Hasan I, Sanityoso A, Miskad US, Yusuf I, et al: Hepatitis C virus genotype in blood donors and associated liver disease in Indonesia. Intervirology. 51:410–416. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Gonçales FL Jr, Häussinger D, Diago M, Carosi G, Dhumeaux D, et al: Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med. 347:975–982. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Kieffer TL, Sarrazin C, Miller JS, Welker MW, Forestier N, Reesink HW, Kwong AD and Zeuzem S: Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients. Hepatology. 46:631–639. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Kieffer TL, Kwong AD and Picchio GR: Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs). J Antimicrob Chemother. 65:202–212. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Allain JP, Thomas I and Sauleda S: Nucleic acid testing for emerging viral infections. Transfus Med. 12:275–283. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Xu GG, Wu SM, Zhou XQ, Zhang QB, Kang LY, Zhou XM, Jiang Y, Qi X and Ren XJ: Clinical characteristics of 638 patients infected with hepatitis C virus by post blood transfusion, in Shanghai. Zhonghua Liu Xing Bing Xue Za Zhi. 32:388–391. 2011.(In Chinese). PubMed/NCBI

19 

Dabbouseh NM and Jensen DM: Future therapies for chronic hepatitis C. Nat Rev Gastroenterol Hepatol. 10:268–276. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Rerksuppaphol S, Hardikar W and Dore GJ: Long-term outcome of vertically acquired and post-transfusion hepatitis C infection in children. J Gastroenterol Hepatol. 19:1357–1362. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Poynard T, Bedossa P and Opolon P: Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR and DOSVIRC groups. Lancet. 349:825–832. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Conjeevaram HS, Fried MW, Jeffers LJ, Terrault NA, Wiley-Lucas TE, Afdhal N, Brown RS, Belle SH, Hoofnagle JH, Kleiner DE, et al: Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1. Gastroenterology. 131:470–477. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Ferenci P, Fried MW, Shiffman ML, Smith CI, Marinos G, Goncales FL Jr, Häussinger D, Diago M, Carosi G, Dhumeaux D, et al: Predicting sustained virological responses in chronic hepatitis C patients treated with peginterferon alfa-2a (40 KD)/ribavirin. J Hepatol. 43:425–433. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Jensen DM, Marcellin P, Freilich B, Andreone P, Di Bisceglie A, Brandão-Mello CE, Reddy KR, Craxi A, Martin AO, Teuber G, et al: Re-treatment of patients with chronic hepatitis C who do not respond to peginterferon-alpha2b: A randomized trial. Ann Intern Med. 150:528–540. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Shiffman ML, Di Bisceglie AM, Lindsay KL, Morishima C, Wright EC, Everson GT, Lok AS, Morgan TR, Bonkovsky HL, Lee WM, et al: Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial Group.: Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment. Gastroenterology. 126:1015–1023; discussion 1947. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Alberti A, Benvegnù L, Boccato S, Ferrari A and Sebastiani G: Natural history of initially mild chronic hepatitis C. Dig Liver Dis. 36:646–654. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Boccato S, Pistis R, Noventa F, Guido M, Benvegnù L and Alberti A: Fibrosis progression in initially mild chronic hepatitis C. J Viral Hepat. 13:297–302. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Mohan P, Barton BA, Narkewicz MR, Molleston JP, Gonzalez-Peralta RP, Rosenthal P, Murray KF, Haber B, Schwarz KB and Goodman ZD: Evaluating progression of liver disease from repeat liver biopsies in children with chronic hepatitis C: A retrospective study. Hepatology. 58:1580–1586. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Casiraghi MA, De Paschale M, Romanò L, Biffi R, Assi A, Binelli G and Zanetti AR: Long-term outcome (35 years) of hepatitis C after acquisition of infection through mini transfusions of blood given at birth. Hepatology. 39:90–96. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Minola E, Prati D, Suter F, Maggiolo F, Caprioli F, Sonzogni A, Fraquelli M, Paggi S and Conte D: Age at infection affects the long-term outcome of transfusion-associated chronic hepatitis C. Blood. 99:4588–4591. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Chen SL and Morgan TR: The natural history of hepatitis C virus (HCV) infection. Int J Med Sci. 3:47–52. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Kiyosawa K, Sodeyama T, Tanaka E, Gibo Y, Yoshizawa K, Nakano Y, Furuta S, Akahane Y, Nishioka K, Purcell RH, et al: Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus. Hepatology. 12:671–675. 1990. View Article : Google Scholar : PubMed/NCBI

33 

Tong MJ, el-Farra NS, Reikes AR and Co RL: Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med. 332:1463–1466. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Salhab M and Canelo R: An overview of evidence-based management of hepatocellular carcinoma: A meta-analysis. J Cancer Res Ther. 7:463–475. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Reggiardo MV, Fay F, Tanno M, Garcia-Camacho G, Bottaso O, Ferretti S, Godoy A, Guerrita C, Paez M, Tanno F, et al: Natural history of hepatitis C virus infection in a cohort of asymptomatic post-transfused subjects. Ann Hepatol. 11:658–666. 2012.PubMed/NCBI

36 

Zavaglia C, Silini E, Mangia A, Airoldi A, Piazzolla V, Vangeli M, Stigliano R, Foschi A, Mazzarelli C and Tinelli C: Prognostic factors of hepatic decompensation and hepatocellular carcinoma in patients with transfusion-acquired HCV infection. Liver Int. 34:e308–e316. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Akiyama T, Mizuta T, Kawazoe S, Eguchi Y, Kawaguchi Y, Takahashi H, Ozaki I and Fujimoto K: Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients. World J Gastroenterol. 17:914–921. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Farinati F, Sergio A, Giacomin A, Di Nolfo MA, Del Poggio P, Benvegnu L, Rapaccini G, Zoli M, Borzio F, Giannini EG, et al: Italian Liver Cancer group: Is female sex a significant favorable prognostic factor in hepatocellular carcinoma? Eur J Gastroenterol Hepatol. 21:1212–1218. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Shimizu I and Ito S: Protection of estrogens against the progression of chronic liver disease. Hepatol Res. 37:239–247. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Kato N, Yokosuka O, Hosoda K, Ito Y, Ohto M and Omata M: Quantification of hepatitis C virus by competitive reverse transcription-polymerase chain reaction: Increase of the virus in advanced liver disease. Hepatology. 18:16–20. 1993. View Article : Google Scholar : PubMed/NCBI

41 

Mita E, Hayashi N, Kanazawa Y, Hagiwara H, Ueda K, Kasahara A, Fusamoto H and Kamada T: Hepatitis C virus genotype and RNA titer in the progression of type C chronic liver disease. J Hepatol. 21:468–473. 1994. View Article : Google Scholar : PubMed/NCBI

42 

Ripoli M and Pazienza V: Impact of HCV genetic differences on pathobiology of disease. Expert Rev Anti Infect Ther. 9:747–759. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Silini E, Bono F, Cividini A, Cerino A, Bruno S, Rossi S, Belloni G, Brugnetti B, Civardi E, Salvaneschi L, et al: Differential distribution of hepatitis C virus genotypes in patients with and without liver function abnormalities. Hepatology. 21:285–290. 1995. View Article : Google Scholar : PubMed/NCBI

44 

Kobayashi M, Tanaka E, Sodeyama T, Urushihara A, Matsumoto A and Kiyosawa K: The natural course of chronic hepatitis C: A comparison between patients with genotypes 1 and 2 hepatitis C viruses. Hepatology. 23:695–699. 1996. View Article : Google Scholar : PubMed/NCBI

45 

Silini E, Bottelli R, Asti M, Bruno S, Candusso ME, Brambilla S, Bono F, Iamoni G, Tinelli C, Mondelli MU and Ideo G: Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: A case-control study. Gastroenterology. 111:199–205. 1996. View Article : Google Scholar : PubMed/NCBI

46 

Takada A, Tsutsumi M, Zhang SC, Okanoue T, Matsushima T, Fujiyama S and Komatsu M: Relationship between hepatocellular carcinoma and subtypes of hepatitis C virus: A nationwide analysis. J Gastroenterol Hepatol. 11:166–169. 1996. View Article : Google Scholar : PubMed/NCBI

47 

Dusheiko G, Schmilovitz-Weiss H, Brown D, McOmish F, Yap PL, Sherlock S, McIntyre N and Simmonds P: Hepatitis C virus genotypes: An investigation of type-specific differences in geographic origin and disease. Hepatology. 19:13–18. 1994. View Article : Google Scholar : PubMed/NCBI

48 

Yamada M, Kakumu S, Yoshioka K, Higashi Y, Tanaka K, Ishikawa T and Takayanagi M: Hepatitis C virus genotypes are not responsible for development of serious liver disease. Dig Dis Sci. 39:234–239. 1994. View Article : Google Scholar : PubMed/NCBI

49 

Dong ZX, Zhou HJ, Wang JH, Xiang XG, Zhuang Y, Guo SM, Gui HL, Zhao GD, Tang WL, Wang H and Xie Q: Distribution of hepatitis C virus genotypes in Chinese patients with chronic hepatitis C: Correlation with patients' characteristics and clinical parameters. J Dig Dis. 13:564–570. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pan YF, Zheng Y, Qin T, Feng L, Zhang Q, Ping XG, Pan YT, Wang XP, Bai L, Li HH, Li HH, et al: Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion. Exp Ther Med 12: 3476-3484, 2016.
APA
Pan, Y., Zheng, Y., Qin, T., Feng, L., Zhang, Q., Ping, X. ... Li, H. (2016). Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion. Experimental and Therapeutic Medicine, 12, 3476-3484. https://doi.org/10.3892/etm.2016.3792
MLA
Pan, Y., Zheng, Y., Qin, T., Feng, L., Zhang, Q., Ping, X., Pan, Y., Wang, X., Bai, L., Li, H."Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion". Experimental and Therapeutic Medicine 12.5 (2016): 3476-3484.
Chicago
Pan, Y., Zheng, Y., Qin, T., Feng, L., Zhang, Q., Ping, X., Pan, Y., Wang, X., Bai, L., Li, H."Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3476-3484. https://doi.org/10.3892/etm.2016.3792
Copy and paste a formatted citation
x
Spandidos Publications style
Pan YF, Zheng Y, Qin T, Feng L, Zhang Q, Ping XG, Pan YT, Wang XP, Bai L, Li HH, Li HH, et al: Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion. Exp Ther Med 12: 3476-3484, 2016.
APA
Pan, Y., Zheng, Y., Qin, T., Feng, L., Zhang, Q., Ping, X. ... Li, H. (2016). Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion. Experimental and Therapeutic Medicine, 12, 3476-3484. https://doi.org/10.3892/etm.2016.3792
MLA
Pan, Y., Zheng, Y., Qin, T., Feng, L., Zhang, Q., Ping, X., Pan, Y., Wang, X., Bai, L., Li, H."Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion". Experimental and Therapeutic Medicine 12.5 (2016): 3476-3484.
Chicago
Pan, Y., Zheng, Y., Qin, T., Feng, L., Zhang, Q., Ping, X., Pan, Y., Wang, X., Bai, L., Li, H."Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3476-3484. https://doi.org/10.3892/etm.2016.3792
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