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Article

Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium

  • Authors:
    • Mariola Herbet
    • Monika Gawrońska‑Grzywacz
    • Magdalena Izdebska
    • Iwona Piątkowska‑Chmiel
  • View Affiliations / Copyright

    Affiliations: Chair and Department of Toxicology, Medical University of Lublin, 20‑093 Lublin, Poland
  • Pages: 3440-3444
    |
    Published online on: October 11, 2016
       https://doi.org/10.3892/etm.2016.3794
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Abstract

Cardiovascular disease and depression often occur simultaneously in the same patient. Long‑term polypharmacotherapy can lead to drug‑induced oxidative stress. Data concerning the effects of concomitant treatment with atorvastatin and selective serotonin reuptake inhibitors (SSRIs) are lacking. The aim of the present study was to examine oxidative stress parameters in the blood of rats after 28 days treatment with atorvastatin combined with fluoxetine or paroxetine. The study was carried out on male Wistar rats weighing 200‑250 g. Aqueous solutions of atorvastatin (10 mg/kg), fluoxetine (10 mg/kg) and paroxetine (10 mg/kg) were injected once a day for 28 days, separately or concomitantly. The activity of glutathione peroxidase (GPX) was determined in the whole blood, whereas the activity of glutathione reductase (GR) and the total antioxidant status (TAS) were determined in the serum. The results demonstrated that concomitant administration of atorvastatin with fluoxetine caused an increase in the GPX activity and the TAS. Atorvastatin administered to rats with paroxetine increased the activities of GPX and GR. In the groups of rats receiving atorvastatin or SSRIs separately, no statistically significant changes in the investigated parameters were observed. The changes that were detected may indicate an increase in endogenous antioxidant levels during the concomitant application of atorvastatin with SSRIs and thus a drug‑drug interaction having an effect on the blood redox equilibrium.
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Copy and paste a formatted citation
Spandidos Publications style
Herbet M, Gawrońska‑Grzywacz M, Izdebska M and Piątkowska‑Chmiel I: Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium. Exp Ther Med 12: 3440-3444, 2016.
APA
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., & Piątkowska‑Chmiel, I. (2016). Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium. Experimental and Therapeutic Medicine, 12, 3440-3444. https://doi.org/10.3892/etm.2016.3794
MLA
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., Piątkowska‑Chmiel, I."Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium". Experimental and Therapeutic Medicine 12.5 (2016): 3440-3444.
Chicago
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., Piątkowska‑Chmiel, I."Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3440-3444. https://doi.org/10.3892/etm.2016.3794
Copy and paste a formatted citation
x
Spandidos Publications style
Herbet M, Gawrońska‑Grzywacz M, Izdebska M and Piątkowska‑Chmiel I: Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium. Exp Ther Med 12: 3440-3444, 2016.
APA
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., & Piątkowska‑Chmiel, I. (2016). Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium. Experimental and Therapeutic Medicine, 12, 3440-3444. https://doi.org/10.3892/etm.2016.3794
MLA
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., Piątkowska‑Chmiel, I."Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium". Experimental and Therapeutic Medicine 12.5 (2016): 3440-3444.
Chicago
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., Piątkowska‑Chmiel, I."Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3440-3444. https://doi.org/10.3892/etm.2016.3794
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