Open Access

Impact of ethyl pyruvate on Adriamycin‑induced cardiomyopathy in rats

  • Authors:
    • Menglin Liu
    • Menglong Wang
    • Jianfang Liu
    • Zhen Luo
    • Lei Shi
    • Ying Feng
    • Li Li
    • Lin Xu
    • Jun Wan
  • View Affiliations

  • Published online on: October 11, 2016     https://doi.org/10.3892/etm.2016.3795
  • Pages: 3201-3208
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ethyl pyruvate (EP), a derivative of pyruvic acid, is known to have protective effects against ischemic cardiomyopathy and other disorders. However, little is known about its role in Adriamycin (ADR)‑induced cardiomyopathy. The present study was designed to investigate the impact of EP on ADR‑induced cardiomyopathy in an animal model. Sixty male Sprague‑Dawley (SD) rats were divided into four groups: Normal control, EP, ADR and ADR + EP groups (n=15/group). Rats in the ADR and ADR + EP groups were treated with ADR (2.5 mg/kg/week intraperitoneally) for 6 weeks. From the eighth week, rats in the EP and ADR + EP groups received EP via gastric lavage at a dose of 50 mg/kg/day for 30 days. After completing the EP treatment, cardiac function was assessed by echocardiography and then rats were sacrificed. Hearts were harvested for subsequent analysis. Compared with rats in the normal control and EP groups (without ADR treatment), rats in the ADR and ADR + EP groups showed significant impairments in terms of cardiac function, apoptosis, severe oxidative stress and fibrosis in the heart. However, these impairments were alleviated by EP treatment in the ADR + EP group. Upon EP treatment, cardiac function was significantly improved. The levels of oxidative stress, fibrosis and apoptosis in the myocardial tissues were also significantly reduced. These findings indicated that EP treatment attenuated, at least partially, ADR‑induced cardiomyopathy in rats.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu M, Wang M, Liu J, Luo Z, Shi L, Feng Y, Li L, Xu L and Wan J: Impact of ethyl pyruvate on Adriamycin‑induced cardiomyopathy in rats. Exp Ther Med 12: 3201-3208, 2016
APA
Liu, M., Wang, M., Liu, J., Luo, Z., Shi, L., Feng, Y. ... Wan, J. (2016). Impact of ethyl pyruvate on Adriamycin‑induced cardiomyopathy in rats. Experimental and Therapeutic Medicine, 12, 3201-3208. https://doi.org/10.3892/etm.2016.3795
MLA
Liu, M., Wang, M., Liu, J., Luo, Z., Shi, L., Feng, Y., Li, L., Xu, L., Wan, J."Impact of ethyl pyruvate on Adriamycin‑induced cardiomyopathy in rats". Experimental and Therapeutic Medicine 12.5 (2016): 3201-3208.
Chicago
Liu, M., Wang, M., Liu, J., Luo, Z., Shi, L., Feng, Y., Li, L., Xu, L., Wan, J."Impact of ethyl pyruvate on Adriamycin‑induced cardiomyopathy in rats". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3201-3208. https://doi.org/10.3892/etm.2016.3795