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Toll‑like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang

  • Authors:
    • Yonghui Jiao
    • Jing Zhao
    • Bo Hu
    • Xiaoling La
    • Xiaoyun Gong
    • Ying Huang
    • Xia Cai
    • Yi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Xiang Ya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Reproductive Medical Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Department of Obstetrics, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830001, P.R. China
    Copyright: © Jiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3268-3274
    |
    Published online on: October 11, 2016
       https://doi.org/10.3892/etm.2016.3796
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Abstract

Toll-like receptor 4 (TLR4), a recently identified vertebrate receptor, serves a pivotal role in immune responses. The aim of the present study was to investigate the association between the human TLR4 gene and recurrent spontaneous miscarriage (RSM). A total of 306 RSM patents and 306 age‑matched controls were genotyped for four single‑nucleotide polymorphisms (SNPs) of the human TLR4 gene (rs1927914, rs1927911, rs4986790 and rs4986791). Data were analyzed for Uygur and Han women separately using a haplotype‑based case‑control study. There were significant differences between the distributions of rs1927914, rs1927911 and rs4986790 SNPs between RSM patients and the controls (P=0.001, P<0.001 and P=0.015, respectively) were identified in Uygur women, and significant differences between the distributions of the rs1927914 and rs1927911 SNPs between RSM patients and the controls (P<0.001 and P<0.001, respectively) were identified in Han women. Results of the logistic regression analysis indicated that rs1927914, rs1927911 and rs4986790 SNPs were significantly higher in the RSM patients compared with the control individuals (P=0.012, P=0.024 and P=0.035, respectively) in Uygur women. Furthermore, significantly higher frequency was noted for the A‑G‑G haplotype (SNP1‑SNP2‑SNP3) (P=0.016) in RSM patients compared with the controls in Uygur women. The results indicate that rs1927914, rs1927911, rs4986790 and the A‑G‑G haplotype (SNP1‑SNP2‑SNP3) of the human TLR4 gene may be genetic markers for RSM in Uygur women, while rs1927914 and rs1927911 SNPs of the human TLR4 gene are most likely associated with RSM in Han women in Xinjiang.
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1 

Rai R and Regan L: Recurrent miscarriage. Lancet. 368:601–611. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Cramer DW and Wise LA: The epidemiology of recurrent pregnancy loss. Semin Reprod Med. 18:331–339. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Ford HB and Schust DJ: Recurrent pregnancy loss: Etiology, diagnosis, and therapy. Rev Obstet Gynecol. 2:76–83. 2009.PubMed/NCBI

4 

Akira S and Takeda K: Functions of toll-like receptors: Lessons from KO mice. C R Biol. 327:581–589. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Kawai T and Akira S: The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat Immunol. 11:373–384. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Marshak-Rothstein A: Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol. 6:823–835. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Schroder NW and Schumann RR: Single nucleotide polymorphisms of toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis. 5:156–164. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Horie Y, Meguro A, Ota M, Kitaichi N, Katsuyama Y, Takemoto Y, Namba K, Yoshida K, Song YW, Park KS, et al: Association of TLR4 polymorphisms with Behcet's disease in a Korean population. Rheumatology (Oxford). 48:638–642. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Pabst S, Baumgarten G, Stremmel A, Lennarz M, Knüfermann P, Gillissen A, Vetter H and Grohé C: Toll-like receptor (TLR) 4 polymorphisms are associated with a chronic course of sarcoidosis. Clin Exp Immunol. 143:420–426. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Frantz S, Ertl G and Bauersachs J: Mechanisms of disease: Toll-like receptors in cardiovascular disease. Nat Clin Pract Cardiovasc Med. 4:444–454. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Varshney RK, Kudapa H, Roorkiwal M, Thudi M, Pandey MK, Saxena RK, Chamarthi SK, Mohan SM, Mallikarjuna N, Upadhyaya H, et al: Advances in genetics and molecular breeding of three legume crops of semi-arid tropics using next-generation sequencing and high-throughput genotyping technologies. J Biosci. 37:811–820. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Sierra S and Stephenson M: Genetics of recurrent pregnancy loss. Semin Reprod Med. 24:17–24. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Cramer DW and Wise LA: The epidemiology of recurrent pregnancy loss. Semin Reprod Med. 18:331–339. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Kuo PL, Huang SC, Chang LW, Lin CH, Tsai WH and Teng YN: Association of extremely skewed X-chromosome inactivation with Taiwanese women presenting with recurrent pregnancy loss. J Formos Med Assoc. 107:340–343. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Pfeiffer KA, Fimmers R, Engels G, van der Ven H and van der Ven K: The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion. Mol Hum Reprod. 7:373–378. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Hodes-Wertz B, Grifo J, Ghadir S, Kaplan B, Laskin CA, Glassner M and Munné S: Idiopathic recurrent miscarriage is caused mostly by aneuploid embryos. Fertil Steril. 98:675–680. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Finan RR, Al-Irhayim Z, Mustafa FE, Al-Zaman I, Mohammed FA, Al-Khateeb GM, Madan S, Issa AA and Almawi WY: Tumor necrosis factor-alpha polymorphisms in women with idiopathic recurrent miscarriage. J Reprod Immunol. 84:186–192. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Paidas MJ, Ku DH, Langhoff-Roos J and Arkel YS: Inherited thrombophilias and adverse pregnancy outcome: Screening and management. Semin Perinatol. 29:150–163. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Metwally M, Saravelos SH, Ledger WL and Li TC: Body mass index and risk of miscarriage in women with recurrent miscarriage. Fertil Steril. 94:290–295. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Dasarathy J, Gruca LL, Bennett C, Parimi PS, Duenas C, Marczewski S, Fierro JL and Kalhan SC: Methionine metabolism in human pregnancy. Am J Clin Nutr. 91:357–365. 2010. View Article : Google Scholar : PubMed/NCBI

21 

O'Dwyer V, Monaghan B, Fattah C, Farah N, Kennelly MM and Turner MJ: Miscarriage after sonographic confirmation of an ongoing pregnancy in women with moderate and severe obesity. Obes Facts. 5:393–398. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Bulut Y, Faure E, Thomas L, Karahashi H, Michelsen KS, Equils O, Morrison SG, Morrison RP and Arditi M: Chlamydial heat shock protein 60 activates macrophages and endothelial cells through toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol. 168:1435–1440. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, et al: Defective LPS signalingin C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science. 282:2085–2088. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J and Pinsky MR: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med. 29:1303–1310. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Rangel-Frausto MS: Sepsis: Still going strong. Arch Med Res. 36:672–681. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Zidi S, Verdi H, Yilmaz-Yalcin Y, Yazici AC, Gazouani E, Mezlini A, Atac FB and Yacoubi-Loueslati B: Involvement of Toll-like receptors in cervical cancer susceptibility among Tunisian women. Bull Cancer. 101:E31–E35. 2014.PubMed/NCBI

27 

He C, Tu H, Sun L, Xu Q, Gong Y, Jing J, Dong N and Yuan Y: SNP interactions of Helicobacter pylori-related host genes PGC, PTPN11, IL1B, and TLR4 in susceptibility to gastric carcinogenesis. Oncotarget. 6:19017–19026. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Rallabhandi P, Bell J, Boukhvalova MS, Medvedev A, Lorenz E, Arditi M, Hemming VG, Blanco JC, Segal DM and Vogel SN: Analysis of TLR4 polymorphic variants: New insights into TLR4/ MD-2/CD14 stoichiometry, structure, and signaling. J Immunol. 177:322–332. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Figueroa L, Xiong Y, Song C, Piao W, Vogel SN and Medvedev AE: The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF. J Immunol. 188:4506–4515. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL and Schwartz DA: TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 25:187–191. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Ferwerda B, McCall MB, Verheijen K, Kullberg BJ, van der Ven AJ, Van der Meer JW and Netea MG: Functional consequences of Toll-like receptor 4 polymorphisms. Mol Med. 14:346–352. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Radstake TR, Franke B, Hanssen S, Netea MG, Welsing P, Barrera P, Joosten LA, van Riel PL and van den Berg WB: The toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. Arthritis Rheum. 50:999–1001. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Hirschfeld AF, Jiang R, Robinson WP, McFadden DE and Turvey SE: Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage. Hum Reprod. 22:440–443. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Almawi WY, Saldanha FL, Mahmood NA, Al-Zaman I, Sater MS and Mustafa FE: Relationship between VEGFA polymorphisms and serum VEGF protein levels and recurrent spontaneous miscarriage. Hum Reprod. 28:2628–2635. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Chen CK, Yu HT, Soong YK and Lee CL: New perspectives on preimplantation genetic diagnosis and preimplantation genetic screening. Taiwan J Obstet Gynecol. 53:146–150. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Stein CM and Elston RC: Finding genes underlying human disease. Clin Genet. 75:101–106. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiao Y, Zhao J, Hu B, La X, Gong X, Huang Y, Cai X and Zhang Y: Toll‑like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang. Exp Ther Med 12: 3268-3274, 2016.
APA
Jiao, Y., Zhao, J., Hu, B., La, X., Gong, X., Huang, Y. ... Zhang, Y. (2016). Toll‑like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang. Experimental and Therapeutic Medicine, 12, 3268-3274. https://doi.org/10.3892/etm.2016.3796
MLA
Jiao, Y., Zhao, J., Hu, B., La, X., Gong, X., Huang, Y., Cai, X., Zhang, Y."Toll‑like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang". Experimental and Therapeutic Medicine 12.5 (2016): 3268-3274.
Chicago
Jiao, Y., Zhao, J., Hu, B., La, X., Gong, X., Huang, Y., Cai, X., Zhang, Y."Toll‑like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3268-3274. https://doi.org/10.3892/etm.2016.3796
Copy and paste a formatted citation
x
Spandidos Publications style
Jiao Y, Zhao J, Hu B, La X, Gong X, Huang Y, Cai X and Zhang Y: Toll‑like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang. Exp Ther Med 12: 3268-3274, 2016.
APA
Jiao, Y., Zhao, J., Hu, B., La, X., Gong, X., Huang, Y. ... Zhang, Y. (2016). Toll‑like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang. Experimental and Therapeutic Medicine, 12, 3268-3274. https://doi.org/10.3892/etm.2016.3796
MLA
Jiao, Y., Zhao, J., Hu, B., La, X., Gong, X., Huang, Y., Cai, X., Zhang, Y."Toll‑like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang". Experimental and Therapeutic Medicine 12.5 (2016): 3268-3274.
Chicago
Jiao, Y., Zhao, J., Hu, B., La, X., Gong, X., Huang, Y., Cai, X., Zhang, Y."Toll‑like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3268-3274. https://doi.org/10.3892/etm.2016.3796
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