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Article Open Access

Effects of the MAPK pathway and the expression of CAR in a murine model of viral myocarditis

Retraction in: /10.3892/etm.2025.12825
  • Authors:
    • Ling Niu
    • Chunli Li
    • Zhenzhou Wang
    • Hui Xu
    • Xinjiang An
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China
    Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 230-234
    |
    Published online on: November 18, 2016
       https://doi.org/10.3892/etm.2016.3909
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Abstract

The pathogenesis of viral myocarditis (VMC) is not fully understood. This study aimed to examine the relationship between coxsackie-adenovirus receptor (CAR) and the p38 mitogen activated protein kinase (MAPK) pathway mechanisms in a mouse model. Three groups of mice were established: 5 mice in a control group injected with saline, 15 in the model group injected with coxsackie virus B3 (CVB) and 15 in the intervention group injected with CVB3 but treated with the p38 MAPK inhibitor SB203580. Mice were sacrificed at days 1, 5, 10, 15 and 30 and cardiac tissues were isolated to perform the tests. Quantitative PCR and western blot analysis showed CAR mRNA and protein expression levels were highest in the model group at all time‑points (P<0.05). The expression levels of p38 MAPK protein by western blot analysis at days 1, 5 and 10 were obviously higher in the model group (P>0.05). H&E staining used to observe myocardial pathological changes showed the inflammatory infiltration was also higher in the model group at all the time-points (P<0.05). Our results show a direct relationship between CAR and p38 MAPK levels, and since the p38 MAPK inhibitor treatment resulted in reduced levels of CAR as well as lower inflammatory infiltration, it is possible that the signaling pathway may mediate CAR expression during the pathogenesis of VMC.
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Copy and paste a formatted citation
Spandidos Publications style
Niu L, Li C, Wang Z, Xu H and An X: Effects of the MAPK pathway and the expression of CAR in a murine model of viral myocarditis Retraction in /10.3892/etm.2025.12825. Exp Ther Med 13: 230-234, 2017.
APA
Niu, L., Li, C., Wang, Z., Xu, H., & An, X. (2017). Effects of the MAPK pathway and the expression of CAR in a murine model of viral myocarditis Retraction in /10.3892/etm.2025.12825. Experimental and Therapeutic Medicine, 13, 230-234. https://doi.org/10.3892/etm.2016.3909
MLA
Niu, L., Li, C., Wang, Z., Xu, H., An, X."Effects of the MAPK pathway and the expression of CAR in a murine model of viral myocarditis Retraction in /10.3892/etm.2025.12825". Experimental and Therapeutic Medicine 13.1 (2017): 230-234.
Chicago
Niu, L., Li, C., Wang, Z., Xu, H., An, X."Effects of the MAPK pathway and the expression of CAR in a murine model of viral myocarditis Retraction in /10.3892/etm.2025.12825". Experimental and Therapeutic Medicine 13, no. 1 (2017): 230-234. https://doi.org/10.3892/etm.2016.3909
Copy and paste a formatted citation
x
Spandidos Publications style
Niu L, Li C, Wang Z, Xu H and An X: Effects of the MAPK pathway and the expression of CAR in a murine model of viral myocarditis Retraction in /10.3892/etm.2025.12825. Exp Ther Med 13: 230-234, 2017.
APA
Niu, L., Li, C., Wang, Z., Xu, H., & An, X. (2017). Effects of the MAPK pathway and the expression of CAR in a murine model of viral myocarditis Retraction in /10.3892/etm.2025.12825. Experimental and Therapeutic Medicine, 13, 230-234. https://doi.org/10.3892/etm.2016.3909
MLA
Niu, L., Li, C., Wang, Z., Xu, H., An, X."Effects of the MAPK pathway and the expression of CAR in a murine model of viral myocarditis Retraction in /10.3892/etm.2025.12825". Experimental and Therapeutic Medicine 13.1 (2017): 230-234.
Chicago
Niu, L., Li, C., Wang, Z., Xu, H., An, X."Effects of the MAPK pathway and the expression of CAR in a murine model of viral myocarditis Retraction in /10.3892/etm.2025.12825". Experimental and Therapeutic Medicine 13, no. 1 (2017): 230-234. https://doi.org/10.3892/etm.2016.3909
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