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Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI

  • Authors:
    • Wenbo Liu
    • Zhipeng Zou
    • Haipeng Jiang
    • Qiang Li
    • Fangming Guo
    • Zhen Wang
    • Hongguang Zhu
  • View Affiliations / Copyright

    Affiliations: Yantaishan Hospital, Yantai, Shandong 264001, P.R. China, Department of Cardiology, Yeda Hospital of Yantai City, Yantai, Shandong 264001, P.R. China, Department of Minimally Invasive Surgery, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China, Department of Cardiology, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China, Department of Cardiology, Haigang Hospital of Yantai City, Yantai, Shandong 264001, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 97-102
    |
    Published online on: November 18, 2016
       https://doi.org/10.3892/etm.2016.3910
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Abstract

The aim of the present study was to evaluate the use of preoperative high-dose atorvastatin to prevent the no-reflow phenomenon after percutaneous coronary intervention (PCI). A total of 138 patients with ST‑segment elevation myocardial infarction, admitted from March 2014 to January 2015, were enrolled and randomly divided into 3 groups of 46 individuals each. The groups included a control group in which patients were not treated with atorvastatin before PCI; a conventional‑dose atorvastatin treatment group in which patients received a single dose of 20 mg at bedtime one day prior to PCI; and a high-dose atorvastatin treatment group in which patients were treated with 40 mg divided in two doses the day before PCI. The treatment effects were assessed by re-examining the echocardiography, high-sensitivity C-reactive protein and brain natriuretic peptide (BNP) levels after the PCI. The follow-up examinations included determinations of ultrasound imaging indicators and the contact with patients was maintained for a whole year. The CTFC (frame), pro-BNP, CK-MB peak and WMSI levels of the patients in the high-dose treatment group were significantly lower than those in the conventional dose or the control group. Trombolysis in myocardial infarction ≤2 and myocardial blush grade ≤1 levels were significantly lower than those in the conventional dose group (P=0.01) or those in the control group (P=0.01), although the echocardiographic indicators of the three groups were not significantly different (P<0.05). Nevertheless, it was found that there were significantly fewer adverse cardiovascular events in the high-dose group (P<0.05 in both cases). During the follow-up period, thromboembolism and restenosis were most infrequent in the high-dose atorvastatin group. Based on our findings the oral administration of high-dose atorvastatin before bedtime, one day before the procedure, can effectively prevent no-reflow cases, reduce adverse events and improve the long-term prognosis for acute coronary syndrome patients after PCI.
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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Zou Z, Jiang H, Li Q, Guo F, Wang Z and Zhu H: Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI. Exp Ther Med 13: 97-102, 2017.
APA
Liu, W., Zou, Z., Jiang, H., Li, Q., Guo, F., Wang, Z., & Zhu, H. (2017). Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI. Experimental and Therapeutic Medicine, 13, 97-102. https://doi.org/10.3892/etm.2016.3910
MLA
Liu, W., Zou, Z., Jiang, H., Li, Q., Guo, F., Wang, Z., Zhu, H."Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI". Experimental and Therapeutic Medicine 13.1 (2017): 97-102.
Chicago
Liu, W., Zou, Z., Jiang, H., Li, Q., Guo, F., Wang, Z., Zhu, H."Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI". Experimental and Therapeutic Medicine 13, no. 1 (2017): 97-102. https://doi.org/10.3892/etm.2016.3910
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Zou Z, Jiang H, Li Q, Guo F, Wang Z and Zhu H: Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI. Exp Ther Med 13: 97-102, 2017.
APA
Liu, W., Zou, Z., Jiang, H., Li, Q., Guo, F., Wang, Z., & Zhu, H. (2017). Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI. Experimental and Therapeutic Medicine, 13, 97-102. https://doi.org/10.3892/etm.2016.3910
MLA
Liu, W., Zou, Z., Jiang, H., Li, Q., Guo, F., Wang, Z., Zhu, H."Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI". Experimental and Therapeutic Medicine 13.1 (2017): 97-102.
Chicago
Liu, W., Zou, Z., Jiang, H., Li, Q., Guo, F., Wang, Z., Zhu, H."Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI". Experimental and Therapeutic Medicine 13, no. 1 (2017): 97-102. https://doi.org/10.3892/etm.2016.3910
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