Effects of salbutamol aerosol combined with magnesium sulfate on T-lymphocyte subgroup and Th1/Th2 cytokines of pediatric asthma
- Authors:
- Min Diao
- Jie Min
- Fei Guo
- Chong-Lin Zhang
View Affiliations
Affiliations: Department of Respiratory Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China
- Published online on: November 18, 2016 https://doi.org/10.3892/etm.2016.3912
-
Pages:
117-120
-
Copyright: © Diao
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
The aim of the study was to analyze the effects of the intravenous infusion of salbutamol aerosol combined with magnesium sulfate in the treatment of pediatric asthma and the subsequent effects on the levels of T‑lymphocyte subgroups and Th1/Th2 cytokines. A total of 86 patients with pediatric asthma, first diagnosed and treated at the Xuzhou Children's Hospital, were continuously selected and randomly divided into an observation group of 44 cases and control group of 42 cases. The patients in the control group were treated with budesonide atomization inhalation, while the children in the observation group were treated with intravenous infusion of salbutamol aerosol combined with magnesium sulfate. The therapeutic effects in the groups were compared. After treatment, the levels of serum CD3+ and CD8+ decreased when compared to before treatment; the levels of CD4+ and CD4+/CD8+ also increased, but the observation group had more significant improvement. Differences were statistically significant (P<0.05). After treatment, the levels of serum interleukin-2 (IL-2) and interferon-γ (IFN-γ) increased when compared to before, while levels of IL-4 and IL-6 decreased, and the observation group had more significant improvement. The differences were statistically significant (P<0.05). After treatment, the levels of VT, t-PTEF/t-E, MTIF/MTEF and TEF75/PTEF increased when compared to before; the observation group had more significant improvement. The differences were statistically significant (P<0.05). The effective rate and degree of treatment for the observation group were significantly higher than those of the control group and differences were statistically significant (P<0.05). The intravenous infusion of salbutamol aerosol combined with magnesium sulfate in the treatment of pediatric asthma can significantly improve therapeutic effects and lung functions, improve immune functions and relieve inflammatory reactions. Therefore, it indicates better clinical application and promotion value.
View References
|
1
|
Gao SJ, Ge YP and Zhang CJ: Correlation
between fractional exhaled nitric oxide levels and efficacy of
inhaled corticosteroids in children with bronchial asthma. Am J
Ther. Mar 17–2016.(Epub ahead of print). View Article : Google Scholar
|
|
2
|
Chen B, Feng S and Yin XW: Clinical
characteristics of different ages of children with acute
exacerbation of bronchial asthma. Zhongguo Dang Dai Er Ke Za Zhi.
18:320–323. 2016.(In Chinese). PubMed/NCBI
|
|
3
|
Nakamura T, Hashizume M, Ueda K, Shimizu
A, Takeuchi A, Kubo T, Hashimoto K, Moriuchi H, Odajima H, Kitajima
T, et al: Asian dust and pediatric emergency department visits due
to bronchial asthma and respiratory diseases in Nagasaki, Japan. J
Epidemiol. May 14–2016.(Epub ahead of print). View Article : Google Scholar
|
|
4
|
Hong J and Bao Y: Emphasis on standardized
diagnosis and treatment of bronchial asthma in children. Zhonghua
Er Ke Za Zhi. 54:161–162. 2016.(In Chinese). PubMed/NCBI
|
|
5
|
Bandaru S, Alvala M, Akka J, Sagurthi SR,
Nayarisseri A, Singh SK and Mundluru HP: Identification of small
molecule as a high affinity β2 agonist irrespectively
targeting wild and mutated (Thr164Ile) β2 adrenergic
receptor in the treatment of bronchial asthma. Curr Pharm Des. May
13–2016.(Epub ahead of print). View Article : Google Scholar
|
|
6
|
Albuali WH: The use of intravenous and
inhaled magnesium sulphate in management of children with bronchial
asthma. J Matern Fetal Neonatal Med. 27:1809–1815. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Han RF, Li HY, Wang JW and Cong XJ: Study
on clinical effect and immunologic mechanism of infants capillary
bronchitis secondary bronchial asthma treated with bacterial
lysates Broncho-Vaxom. Eur Rev Med Pharmacol Sci. 20:2151–2155.
2016.PubMed/NCBI
|
|
8
|
Rogala B, Bozek A, Gluck J and Jarzab J:
Prevalence of IgE-mediated allergy and evaluation of Th1/Th2
cytokine profiles in patients with severe bronchial asthma. Postepy
Dermatol Alergol. 32:274–280. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Al-Daghri NM, Alokail MS, Draz HM,
Abd-Alrahman SH, Yakout SM and Clerici M: Th1/Th2 cytokine pattern
in Arab children with severe asthma. Int J Clin Exp Med.
7:2286–2291. 2014.PubMed/NCBI
|
|
10
|
Yamada Y, Matsumoto K, Hashimoto N,
Saikusa M, Homma T, Yoshihara S and Saito H: Effect of Th1/Th2
cytokine pretreatment on RSV-induced gene expression in airway
epithelial cells. Int Arch Allergy Immunol. 154:185–194. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Shah NJ, Kumar S Vinod, Gurusamy U,
Sudarsan AK Annan and Shewade DG: Effect of ADRB2 (adrenergic
receptor β2) gene polymorphisms on the occurrence of
asthma and on the response to nebulized salbutamol in South Indian
patients with bronchial asthma. J Asthma. 52:755–762. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Grover S, Jindal A, Bansal A and Singhi
SC: Acute bronchial asthma. Indian J Pediatr. 78:1388–1395. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Lajqi N, Ilazi A, Kastrati B and Islami H:
Comparison of glucocorticoid (budesonide) and antileukotriene
(montelukast) effect in patients with bronchial asthma determined
with body plethysmography. Acta Inform Med. 23:347–351. 2015.
View Article : Google Scholar : PubMed/NCBI
|
