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Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population

  • Authors:
    • Meijun Chen
    • Xuelong Zhang
    • Qingxiao Fang
    • Tongtong Wang
    • Tingting Li
    • Hong Qiao
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Laboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 121-126
    |
    Published online on: November 18, 2016
       https://doi.org/10.3892/etm.2016.3920
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Abstract

An Indian study recently observed three new loci: rs9552911 in the SGCG, rs1593304 near PLXNA4 and rs4858889 in SCAP associated with type 2 diabetes mellitus (T2DM) in a south Asian population. The present study aimed to validate these findings in a Chinese population. We genotyped the above three single-nucleotide polymorphisms (SNPs), rs9552911, rs1593304, and rs4858889, in a group of 1,972 Chinese individuals, comprising of 966 type 2 diabetic patients and 976 controls. Anthropometric variables and biochemical traits were measured in all the participants. The association analyses of genotype-disease and genotype‑traits were estimated. The genotype frequency of rs9552911 differed statistically between the cases and controls (P=0.017). The difference was also evident between the cases and controls in non-obese participants (P=0.033). In addition, the SNP rs9552911 was associated with weight (P=0.033), total cholesterol (P=0.006) and low-density lipoprotein-cholesterol (P=0.007). The SNP rs1593304 was associated with β-cell function estimated by the homeostatic model assessment of β-cell function (P=0.041). However, there was no significant association between rs4858889 and T2DM. In conclusion, the results show that the SNP rs9552911 was associated with T2DM, possibly by affecting body mass index and lipid metabolism. The SNP rs1593304 may impair β-cell function.
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Copy and paste a formatted citation
Spandidos Publications style
Chen M, Zhang X, Fang Q, Wang T, Li T and Qiao H: Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population. Exp Ther Med 13: 121-126, 2017.
APA
Chen, M., Zhang, X., Fang, Q., Wang, T., Li, T., & Qiao, H. (2017). Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population. Experimental and Therapeutic Medicine, 13, 121-126. https://doi.org/10.3892/etm.2016.3920
MLA
Chen, M., Zhang, X., Fang, Q., Wang, T., Li, T., Qiao, H."Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population". Experimental and Therapeutic Medicine 13.1 (2017): 121-126.
Chicago
Chen, M., Zhang, X., Fang, Q., Wang, T., Li, T., Qiao, H."Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population". Experimental and Therapeutic Medicine 13, no. 1 (2017): 121-126. https://doi.org/10.3892/etm.2016.3920
Copy and paste a formatted citation
x
Spandidos Publications style
Chen M, Zhang X, Fang Q, Wang T, Li T and Qiao H: Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population. Exp Ther Med 13: 121-126, 2017.
APA
Chen, M., Zhang, X., Fang, Q., Wang, T., Li, T., & Qiao, H. (2017). Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population. Experimental and Therapeutic Medicine, 13, 121-126. https://doi.org/10.3892/etm.2016.3920
MLA
Chen, M., Zhang, X., Fang, Q., Wang, T., Li, T., Qiao, H."Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population". Experimental and Therapeutic Medicine 13.1 (2017): 121-126.
Chicago
Chen, M., Zhang, X., Fang, Q., Wang, T., Li, T., Qiao, H."Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population". Experimental and Therapeutic Medicine 13, no. 1 (2017): 121-126. https://doi.org/10.3892/etm.2016.3920
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