Effect of a small dose of aspirin on quantitative test of 24-h urinary protein in patients with hypertension in pregnancy

Liu,Fangmei; Yang,Huili; Li,Guiyun; Zou,Kun; Chen,Yana

doi:10.3892/etm.2016.3924

January-2017 Volume 13 Issue 1

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January-2017 Volume 13 Issue 1

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Article Open Access

Effect of a small dose of aspirin on quantitative test of 24-h urinary protein in patients with hypertension in pregnancy

Authors:
- Fangmei Liu
- Huili Yang
- Guiyun Li
- Kun Zou
- Yana Chen
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Jinan Central Hospital, Shandong University, Jinan, Shandong 250013, P.R. China, Department of Obstetrics and Gynecology, The First People's Hospital of Jinan, Jinan, Shandong 250000, P.R. China

Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 37-40
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Published online on: November 22, 2016

https://doi.org/10.3892/etm.2016.3924
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Abstract

The aim of the present study was to determine the effect of a small dose of aspirin on a quantitative test of 24-h urinary protein in patients with hypertension in pregnancy. In total, 224 patients with hypertension in pregnancy were continuously selected and were randomly divided into the control group (50 cases with conventional therapy), aspirin 50 mg/day group (60 cases), aspirin 75 mg/day group (58 cases), and aspirin 100 mg/day group (56 cases). Clinical effects were compared from 16 gestational weeks to childbirth. According to the comparison in the four groups, there was no statistical difference in the mean arterial pressure, pre-eclampsia rate, gestational weeks, and caesarean section rate (p>0.05). The 24‑h urinary protein and endothelin-1 (ET-1) level were significantly decreased following treatment, and were less than the control and 50 mg/day groups. The superoxide dismutase (SOD) level was significantly increased, and higher than the control and 50 mg/day groups. In terms of the 75 and 100 mg/day, control and 50 mg/day groups, there was no statistical difference (p>0.05). A comparison of the complication rate in the four groups of fetuses during the perinatal period, no statistical difference was observed (p>0.05). Thus, the results show that, regarding patients with hypertension in pregnancy, 75 mg/day aspirin can decrease the 24-h urinary protein, SOD, and ET-1 level. However, the results remain to be confirmed to improve maternal and infant outcome in delivery.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of a small dose of aspirin on quantitative test of 24-h urinary protein in patients with hypertension in pregnancy

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