Open Access

Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice

  • Authors:
    • Hyoung‑Min Han
    • Su‑Hyun Hong
    • Heung‑Sik Park
    • Jae‑Chul Jung
    • Jong‑Sik Kim
    • Yong‑Tae Lee
    • Eun‑Woo Lee
    • Yung‑Hyun Choi
    • Byung‑Woo Kim
    • Cheol‑Min Kim
    • Kyung‑Hwa Kang
  • View Affiliations

  • Published online on: November 25, 2016     https://doi.org/10.3892/etm.2016.3929
  • Pages: 146-154
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Styphnolobium japonicum (L.) is utilized in Korean medicine for the treatment of various inflammatory diseases. The aim of the present study was to explore the effects of Fructus sophorae extract (FSE) isolated from the dried ripe fruit of S. japonicum (L.) on the development of type II collagen‑induced arthritis (CIA) in BALB/c mice. The CIA mice were orally administered FSE or saline daily for 2 weeks. The incidence and severity of disease and the inflammatory response in the serum and the joint tissues were assessed. Macroscopic and histological investigation indicated that FSE protected against CIA development. FSE was associated with a significant reduction in the levels of total immunoglobulin G2a and proinflammatory cytokines and mediators in the serum. In addition, FSE suppressed the gene expression levels of proinflammatory cytokines and mediators, the mediator of osteoclastic bone remodeling, the receptor activator of nuclear factor κ‑B ligand and matrix metalloproteinases in the joint tissues. The present results suggest that FSE may protect against inflammation and bone damage, and would be a valuable candidate for further investigation as a novel anti-arthritic agent.
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January-2017
Volume 13 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Han HM, Hong SH, Park HS, Jung JC, Kim JS, Lee YT, Lee EW, Choi YH, Kim BW, Kim CM, Kim CM, et al: Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice. Exp Ther Med 13: 146-154, 2017
APA
Han, H., Hong, S., Park, H., Jung, J., Kim, J., Lee, Y. ... Kang, K. (2017). Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice. Experimental and Therapeutic Medicine, 13, 146-154. https://doi.org/10.3892/etm.2016.3929
MLA
Han, H., Hong, S., Park, H., Jung, J., Kim, J., Lee, Y., Lee, E., Choi, Y., Kim, B., Kim, C., Kang, K."Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice". Experimental and Therapeutic Medicine 13.1 (2017): 146-154.
Chicago
Han, H., Hong, S., Park, H., Jung, J., Kim, J., Lee, Y., Lee, E., Choi, Y., Kim, B., Kim, C., Kang, K."Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice". Experimental and Therapeutic Medicine 13, no. 1 (2017): 146-154. https://doi.org/10.3892/etm.2016.3929