Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2017 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2017 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats

  • Authors:
    • Xinyu Hu
    • Chungang Liu
    • Xue Wang
    • Dongxu Jia
    • Wenqian Lu
    • Xiaoqi Sun
    • Yang Liu
    • Lijia Yuan
  • View Affiliations / Copyright

    Affiliations: Faculty of Medicine, Changchun Medical College, Changchun, Jilin 130013, P.R. China, School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China, Engineering Research Center of the Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China, Center for Drug Evaluation of China, Beijing 100038, P.R. China
  • Pages: 352-358
    |
    Published online on: December 1, 2016
       https://doi.org/10.3892/etm.2016.3943
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Due to substantial morbidity and complications including nephropathy, a search for alternative treatment of diabetes mellitus is urgently required. The present study aimed to investigate the hypoglycemic and anti-diabetic nephropathy activities of polysaccharides separated from Auricularia auricular (AAP). Diet streptozotocin (STZ)‑induced diabetic Sprague‑Dawley rats were orally treated with metformin (100 mg/kg; positive control) and AAP (100 and 400 mg/kg) for four weeks, and parameters in the serum and liver associated with blood glucose, free radicals and nephropathy were determined. Similar to metformin, AAP treatment strongly reduced blood glucose levels by promoting glucose metabolism. The anti-oxidative activity of AAP, which was indicated by the modulation of superoxide dismutase, glutathione peroxidase, reactive oxygen species and methane dicarboxylic aldehyde levels in serum, was observed in diabetic rats. Furthermore, the regulatory effects of AAP on blood urea nitrogen, creatinine, uric protein and inflammatory‑related factors revealed its protection against diabetic nephropathy. The present data suggests that AAP‑mediated anti‑diabetic and anti‑nephritic effects are partially associated with their modulations on the anti‑oxidative system and nuclear factor kappa B-related signaling pathway. In conclusion, AAP has potential to be a novel source of treatments for diabetes.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Wild S, Roglic G, Green A, Sicree R and King H: Global prevalence of diabetes: Estimates for the year and projections for 2030. Diabetes Care. 27:1047–1053. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Cao Z and Cooper M: Pathogenesis of diabetic nephropathy. J Diabetes Investig. 2:243–247. 2011. View Article : Google Scholar : PubMed/NCBI

3 

You Q, Chen F, Wang X, Luo PG and Jiang Y: Inhibitory effects of muscadine anthocyanins on α-glucosidase and pancreatic lipase activities. J Agric Food Chem. 59:9506–9511. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Winkler G, Hidvégi T, Vándorfi G and Jermendy G: Risk-stratified screening for type 2 diabetes in adult subjects: Results from Hungary. Orv Hetil. 151:691–696. 2010.(In Hungarian). View Article : Google Scholar : PubMed/NCBI

5 

Levterova BA, Dimitrova DD, Levterov GE and Dragova EA: Instruments for disease-specific quality-of-life measurement in patients with type 2 diabetes mellitus-a systematic review. Folia Med (Plovdiv). 55:83–92. 2013.PubMed/NCBI

6 

Scheen A: Antidiabetic agents in subjects with mild dysglycaemia: Prevention or early treatment of type 2 diabetes? Diabetes Metab. 33:3–12. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Jiang X, Zhao X, Luo H and Zhu K: Therapeutic effect of polysaccharide of large yellow croaker swim bladder on lupus nephritis of mice. Nutrients. 6:1223–1235. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Zhang G, Huang Y, Bian Y, Wong JH, Ng TB and Wang H: Hypoglycemic activity of the fungi Cordyceps militaris, Cordyceps sinensis, Tricholoma mongolicum, and Omphalia lapidescens in streptozotocin-induced diabetic rats. Appl Microbiol Biotechnol. 72:1152–1156. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Zhang H, Wang ZY, Yang L, Yang X, Wang X and Zhang Z: In vitro antioxidant activities of sulfated derivatives of polysaccharides extracted from Auricularia auricular. Int J Mol Sci. 12:3288–3302. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Bai H, Wang Z, Cui J, Yun K, Zhang H, Liu RH, Fan Z and Cheng C: Synergistic radiation protective effect of purified Auricularia auricular-judae polysaccharide (AAP IV) with grape seed procyanidins. Molecules. 19:20675–20694. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Yao Y, Sang W, Zhou M and Ren G: Antioxidant and alpha-glucosidase inhibitory activity of colored grains in China. J Agric Food Chem. 58:770–774. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Adisa RA, Choudhary MI and Olorunsogo OO: Hypoglycemic activity of Buchholzia coriacea (Capparaceae) seeds in streptozotocin-induced diabetic rats and mice. Exp Toxicol Pathol. 63:619–625. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Dong Y, Jing T, Meng Q, Liu C, Hu S, Ma Y, Liu Y, Lu J, Cheng Y, Wang D and Teng L: Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats. Biomed Res Int. 2014:1609802014. View Article : Google Scholar : PubMed/NCBI

14 

Gilmore TD: Introduction to NF-kappaB: Players, pathways, perspectives. Oncogene. 25:6680–6684. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Freise C and Querfeld U: The lignan (+)-episesamin interferes with TNF-α-induced activation of VSMC via diminished activation of NF-ĸB, ERK1/2 and AKT and decreased activity of gelatinases. Acta Physiol (Oxf). 213:642–652. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Park JH and Levitt L: Overexpression of mitogen-activated protein kinase (ERK1) enhances T-cell cytokine gene expression: Role of AP1, NF-AT and NF-κB. Blood. 82:2470–2477. 1993.PubMed/NCBI

17 

Fröde T and Medeiros Y: Animal models to test drugs with potential antidiabetic activity. J Ethnopharmacol. 115:173–183. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Federiuk I, Casey H, Quinn M, Wood M and Ward W: Induction of type-1 diabetes mellitus in laboratory rats by use of alloxan: Route of administration, pitfalls, and insulin treatment. Comp Med. 54:252–257. 2004.PubMed/NCBI

19 

Kumar G, Shetty A and Salimath P: Modulatory effect of bitter gourd (Momordica charantia LINN.) on alterations in kidney heparan sulfate in streptozotocin-induced diabetic rats. J Ethnopharmacol. 115:276–283. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Wang BS, Lee CP, Chen ZT, Yu HM and Duh PD: Comparison of the hepatoprotective activity between cultured Cordyceps militaris and natural Cordyceps sinensis. J Agric Food Chem. 4:489–495. 2012.

21 

International Diabetes Federation, . Diabetes and the millennium development goals. Diabetes Res Clin Pract. 100:409–410. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Park JH, Park NS, Lee SM and Park E: Effect of dongchunghacho rice on blood glucose level, lipid profile and antioxidant metabolism in streptozotocin-induced diabetic rats. Food Sci Biotechnol. 20:933–940. 2011. View Article : Google Scholar

23 

Whaley-Connell A, McCullough PA and Sowers JR: The role of oxidative stress in the metabolic syndrome. Rev Cardiovasc Med. 12:21–29. 2011.PubMed/NCBI

24 

Suryawanshi NP, Bhutey AK, Nagdeote AN, Jadhav AA and Manoorkar GS: Study of lipid peroxide and lipid profile in diabetes mellitus. Indian J Clin Biochem. 21:126–130. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Bergamini CM and Seghieri G: ROS and kidney disease in the evolution from acute phase to chronic end stage disease: A commentary on ‘Oxidative signaling in renal epithelium: Critical role of cPLA2 and p38SAPK’. Free Radic Biol Med. 41:190–192. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Sebai H, Selmi S, Rtibi K, Souli A, Gharbi N and Sakly M: Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. Lipids Health Dis. 12:1892013. View Article : Google Scholar : PubMed/NCBI

27 

Fu H, Li J, Li QX, Xia L and Shao L: Protective effect of ligustrazine on accelerated anti-glomerular basement membrane antibody nephritis in rats is based on its antioxidant properties. Eur J Pharmacol. 563:197–202. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Zhang M, Lv XY, Li J, Xu ZG and Chen L: The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model. Exp Diabetes Res. 2008:7040452008. View Article : Google Scholar : PubMed/NCBI

29 

van Dijk C and Berl T: Pathogenesis of diabetic nephropathy. Rev Endocr Metab Disord. 5:237–248. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Lei Y-C, Hwang JS, Chan CC, Lee CT and Cheng TJ: Enhanced oxidative stress and endothelial dysfunction in streptozotocin-diabetic rats exposed to fine particles. Environ Res. 99:335–343. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Valentovic MA, Alejandro N, Carpenter A Betts, Brown PI and Ramos K: Streptozotocin (STZ) diabetes enhances benzo (alpha) pyrene induced renal injury in Sprague Dawley rats. Toxicol Lett. 164:214–220. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Li S, Zhang Y and Zhao J: Preparation and suppressive effect of astragalus polysaccharide in glomerulonephritis rats. Int Immunopharmacol. 7:23–28. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Raga S, Julia MR, Crespi C, Figuerola J, Martínez N, Milà J and Matamoros N: Gammadelta T lymphocytes from cystic fibrosis patients and healthy donors are high TNF-alpha and IFN-gamma-producers in response to Pseudomonas aeruginosa. Respir Res. 4:92003. View Article : Google Scholar : PubMed/NCBI

34 

Johansen HK, Hougen HP, Rygaard J and Høiby N: Interferon-gamma (IFN-gamma) treatment decreases the inflammatory response in chronic Pseudomonas aeruginosa pneumonia in rats. Clin Exp Immunol. 103:212–218. 1996. View Article : Google Scholar : PubMed/NCBI

35 

Moss RB, Bocian RC, Hsu YP, Dong YJ, Kemna M, Wei T and Gardner P: Reduced IL-10 secretion by CD4+ T lymphocytes expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR). Clin Exp Immunol. 106:374–388. 1996. View Article : Google Scholar : PubMed/NCBI

36 

Selleri C, Sato T, Anderson S, Young NS and Maciejewski JP: Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death. J Cell Physiol. 165:538–546. 1995. View Article : Google Scholar : PubMed/NCBI

37 

Zhang S, Xin H, Li Y, Zhang D, Shi J, Yang J and Chen X: Skimmin, a coumarin from hydrangea paniculata, slows down the progression of membranous glomerulonephritis by anti-inflammatory effects and inhibiting immune complex deposition. Evid Based Complement Alternat Med. 2013:8192962013.PubMed/NCBI

38 

Pan P, Wang YJ, Han L, Liu X, Zhao M and Yuan YF: Effects of sodium houttuyfonate on expression of NF-κB and MCP-1 in membranous glomerulonephritis. J Ethnopharmacol. 131:203–209. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Barnes PJ and Karin M: Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 336:1066–1071. 1997. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu X, Liu C, Wang X, Jia D, Lu W, Sun X, Liu Y and Yuan L: Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats. Exp Ther Med 13: 352-358, 2017.
APA
Hu, X., Liu, C., Wang, X., Jia, D., Lu, W., Sun, X. ... Yuan, L. (2017). Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats. Experimental and Therapeutic Medicine, 13, 352-358. https://doi.org/10.3892/etm.2016.3943
MLA
Hu, X., Liu, C., Wang, X., Jia, D., Lu, W., Sun, X., Liu, Y., Yuan, L."Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats". Experimental and Therapeutic Medicine 13.1 (2017): 352-358.
Chicago
Hu, X., Liu, C., Wang, X., Jia, D., Lu, W., Sun, X., Liu, Y., Yuan, L."Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats". Experimental and Therapeutic Medicine 13, no. 1 (2017): 352-358. https://doi.org/10.3892/etm.2016.3943
Copy and paste a formatted citation
x
Spandidos Publications style
Hu X, Liu C, Wang X, Jia D, Lu W, Sun X, Liu Y and Yuan L: Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats. Exp Ther Med 13: 352-358, 2017.
APA
Hu, X., Liu, C., Wang, X., Jia, D., Lu, W., Sun, X. ... Yuan, L. (2017). Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats. Experimental and Therapeutic Medicine, 13, 352-358. https://doi.org/10.3892/etm.2016.3943
MLA
Hu, X., Liu, C., Wang, X., Jia, D., Lu, W., Sun, X., Liu, Y., Yuan, L."Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats". Experimental and Therapeutic Medicine 13.1 (2017): 352-358.
Chicago
Hu, X., Liu, C., Wang, X., Jia, D., Lu, W., Sun, X., Liu, Y., Yuan, L."Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats". Experimental and Therapeutic Medicine 13, no. 1 (2017): 352-358. https://doi.org/10.3892/etm.2016.3943
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team