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Article Open Access

Comparison of the efficacy of four endobronchial ablation techniques in dogs

  • Authors:
    • Linrong Tong
    • Koudong Zhang
    • Haidong Huang
    • Wei Zhang
    • Xingxing Zhang
    • Qin Wang
    • Qiang Li
    • Chong Bai
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Xiamen 174 Hospital, Xiamen, Fujian 361000, P.R. China, Department of Respiratory Medicine, Yancheng City First People's Hospital, Yancheng, Jiangsu 224000, P.R. China, Department of Respiratory Medicine, Changhai Hospital, Shanghai 200433, P.R. China
    Copyright: © Tong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 169-177
    |
    Published online on: December 1, 2016
       https://doi.org/10.3892/etm.2016.3946
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Abstract

The present study aimed to evaluate the safety and efficacy of four commonly used ablation techniques, namely neodymium-doped yttrium aluminium garnet (Nd:YAG) laser therapy, argon plasma coagulation (APC), high‑frequency electrocautery and CO2 cryotherapy. The techniques were performed at various powers or impedance settings, and for various durations, on the trachea of beagle dogs. Pathological changes of the tracheal wall were assessed by bronchoscopy. The endoscopic gross appearance of lesions induced by ablation treatments was consistent with the histopathological changes. The results suggested that cryotherapy was relatively safe, whereas APC induced superficial tissue coagulative necrosis. Furthermore, Nd:YAG laser therapy was the most efficient technique and showed the greatest penetration potential. In general, tissue injury was exacerbated with extended application time, at constant power or impedance. The safest application parameters were 20 W for ≤1 sec for Nd:YAG laser therapy, 40 W for ≤3 sec for electrocautery, 40 W for ≤5 sec for APC and 100 Ω for ≤120 sec for cryotherapy. At the maximum times, these settings resulted in identical pathological changes. Healing of the lesions following ablation was achieved within 3 weeks. The Nd:YAG laser, APC, electrocautery and cryotherapy endobronchial ablation techniques differed according to their potential and limitations for application on the trachea. However, when applied at specific combinations of power or impedance and duration, they exhibited similar efficacies.
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Copy and paste a formatted citation
Spandidos Publications style
Tong L, Zhang K, Huang H, Zhang W, Zhang X, Wang Q, Li Q and Bai C: Comparison of the efficacy of four endobronchial ablation techniques in dogs. Exp Ther Med 13: 169-177, 2017.
APA
Tong, L., Zhang, K., Huang, H., Zhang, W., Zhang, X., Wang, Q. ... Bai, C. (2017). Comparison of the efficacy of four endobronchial ablation techniques in dogs. Experimental and Therapeutic Medicine, 13, 169-177. https://doi.org/10.3892/etm.2016.3946
MLA
Tong, L., Zhang, K., Huang, H., Zhang, W., Zhang, X., Wang, Q., Li, Q., Bai, C."Comparison of the efficacy of four endobronchial ablation techniques in dogs". Experimental and Therapeutic Medicine 13.1 (2017): 169-177.
Chicago
Tong, L., Zhang, K., Huang, H., Zhang, W., Zhang, X., Wang, Q., Li, Q., Bai, C."Comparison of the efficacy of four endobronchial ablation techniques in dogs". Experimental and Therapeutic Medicine 13, no. 1 (2017): 169-177. https://doi.org/10.3892/etm.2016.3946
Copy and paste a formatted citation
x
Spandidos Publications style
Tong L, Zhang K, Huang H, Zhang W, Zhang X, Wang Q, Li Q and Bai C: Comparison of the efficacy of four endobronchial ablation techniques in dogs. Exp Ther Med 13: 169-177, 2017.
APA
Tong, L., Zhang, K., Huang, H., Zhang, W., Zhang, X., Wang, Q. ... Bai, C. (2017). Comparison of the efficacy of four endobronchial ablation techniques in dogs. Experimental and Therapeutic Medicine, 13, 169-177. https://doi.org/10.3892/etm.2016.3946
MLA
Tong, L., Zhang, K., Huang, H., Zhang, W., Zhang, X., Wang, Q., Li, Q., Bai, C."Comparison of the efficacy of four endobronchial ablation techniques in dogs". Experimental and Therapeutic Medicine 13.1 (2017): 169-177.
Chicago
Tong, L., Zhang, K., Huang, H., Zhang, W., Zhang, X., Wang, Q., Li, Q., Bai, C."Comparison of the efficacy of four endobronchial ablation techniques in dogs". Experimental and Therapeutic Medicine 13, no. 1 (2017): 169-177. https://doi.org/10.3892/etm.2016.3946
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