Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2017 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2017 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis

  • Authors:
    • Jiafeng Chen
    • Chunkui Zhou
    • Lijun Zhu
    • Xiuli Yan
    • Yonghong Wang
    • Xin Chen
    • Shaokuan Fang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Neuroscience Centre, The First Teaching Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Neurology, The Third Teaching Hospital of Jilin University, Changchun, Jilin 130041, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 91-96
    |
    Published online on: December 2, 2016
       https://doi.org/10.3892/etm.2016.3950
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

It remains challenging to locate occult lesions in patients with multiple sclerosis (MS). Diffusion tensor imaging (DTI) has been demonstrated to have the potential to identify occult changes in MS lesions. The present study used 3.0T magnetic resonance DTI to investigate the characteristics of different stages of MS lesions. DTI parameters, fractional anisotropy (FA), mean diffusivity (MD), λ// and λ┴ values of lesions were compared at the different stages of 10 patients with MS with 10 normal controls. The results demonstrated that FA and λ// values of MS silent and subacute lesions are decreased and MD and λ┴ values are increased, as compared with those of normal appearing white matter (NAWM) and normal controls. NAWM FA values were lower, and MD, λ//, and λ┴ values were higher than those of normal controls. It was also indicated that MS lesions had reduced color signals compared with the controls, and the lesion area appeared larger using DTI as compared with diffusion‑weighted imaging. Furthermore, fiber abnormalities were detected in MS lesions using DTT, with fewer fibers connected to the lesion side, as compared with the contralateral side. FA, MD, λ// and λ┴ values in the thalamus were increased, as compared with those of normal controls (P<0.05); whereas MD, λ// and λ┴ values were significantly increased and FA values significantly decreased in the caudate nucleus and deep brain gray matter (DBGM) of patients with MS, as compared with the controls (P<0.05). λ// and λ┴ values were also significantly increased in the DBGM of patients with MS as compared with normal controls (P<0.05). The present findings demonstrate that DTI may be useful in the characterization of MS lesions.
View Figures

Figure 1

View References

1 

Balcer LJ: Clinical practice. Optic neuritis. N Engl J Med. 354:1273–1280. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Shams PN and Plant GT: Optic neuritis: A review. Int MS J. 16:82–89. 2009.PubMed/NCBI

3 

Heesen C, Kasper J, Segal J, Köpke S and Mühlhauser I: Decisional role preferences, risk knowledge and information interests in patients with multiple sclerosis. Mult Scler. 10:643–650. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Barkhof F: The clinico-radiological paradox in multiple sclerosis revisited. Curr Opin Neurol. 15:239–245. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Beaulieu C: The basis of anisotropic water diffusion in the nervous system-a technical review. NMR Biomed. 15:435–455. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Yamout B, Alroughani R, Al-Jumah M, Khoury S, Abouzeid N, Dahdaleh M, Alsharoqi I, Inshasi J, Hashem S, Zakaria M, et al: Consensus guidelines for the diagnosis and treatment of multiple sclerosis. Curr Med Res Opin. 29:611–621. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Szeszko PR, Vogel J, Ashtari M, Malhotra AK, Bates J, Kane JM, Bilder RM, Frevert T and Lim K: Sex differences in frontal lobe white matter microstructure: A DTI study. Neuroreport. 14:2469–2473. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Kealey SM, Kim Y, Whiting WL, Madden DJ and Provenzale JM: Determination of multiple sclerosis plaque size with diffusion-tensor MR imaging: Comparison study with healthy volunteers. Radiology. 236:615–620. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Ciccarelli O, Werring DJ, Barker GJ, Griffin CM, Wheeler-Kingshott CA, Miller DH and Thompson AJ: A study of the mechanisms of normal appearing white matter damage in multiple sclerosis using diffusion tensor imaging-evidence of Wallerian degeneration. J Neuro1. 250:287–292. 2003.

10 

Lucchinetti CF, Brück W and Noseworthy J: Multiple sclerosis: Recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment. Curr Opin Neurol. 14:259–269. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Storch MK, Piddlesden S, Haltia M, Iivanainen M, Morgan P and Lassmann H: Multiple sclerosis: In situ evidence for antibody- and complement-mediated demyelination. Ann Neurol. 43:465–471. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Kolbe S, Bajraszewski C, Chapman C, Nguyen T, Mitchell P, Paine M, Butzkueven H, Johnston L, Kilpatrick T and Egan G: Diffusion tensor imaging of the optic radiations after optic neuritis. Hum Brain Mapp. 33:2047–2061. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Zhang J, Jones M, DeBoy CA, Reich DS, Farrell JA, Hoffman PN, Griffin JW, Sheikh KA, Miller MI, Mori S and Calabresi PA: Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomy. J Neurosci. 29:3160–3171. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Song SK, Sun SW, Ju WK, Lin SJ, Cross AH and Neufeld AH: Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage. 20:1714–1722. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Trip SA, Wheeler-Kingshott C, Jones SJ, Li WY, Barker GJ, Thompson AJ, Plant GT and Miller DH: Optic nerve diffusion tensor imaging in optic neuritis. Neuroimage. 30:498–505. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Lucchinetti CF, Brück W, Parisi J, Scheithauer B, Rodriguez M and Lassmann H: Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann Neurol. 47:707–717. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Lucchinetti CF, Bruck W and Lassmann H: Evidence for pathogenic heterogeneity in multiple sclerosis. Ann Neurol. 56:3082004. View Article : Google Scholar : PubMed/NCBI

18 

Barnett MH and Prineas JW: Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion. Ann Neurol. 55:458–468. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Weinshenker BG: The natural history of multiple sclerosis. Neurol Clin. 13:119–146. 1995.PubMed/NCBI

20 

Lucchinetti CF, Bruck W and Lassmann H: Pathology and pathogenesis of multiple sclerosis. 2nd. Elsevier Science; USA: 2003

21 

Pulizzi A, Rovaris M, Judica E, Sormani MP, Martinelli V, Comi G and Filippi M: Determinants of disability in multiple sclerosis at various disease stages: A muitiparametric magnetic resonance study. Arch Neurol. 64:1163–1168. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, Littman DR, Dustin ML and Gan WB: ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci. 8:752–758. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Griffin CM, Chard DT, Ciccarelli O, Kapoor B, Barker GJ, Thompson AI and Miller DH: Diffusion tensor imaging in early relapsing-remitting multiple sclerosis. Mult Scler. 7:290–297. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Filippi M, Bozzali M and Comi G: Magnetization transfer and diffusion tensor MR imaging of basal ganglia from patients with multiple sclerosis. J Neurol Sci. 183:69–72. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Steenwijk MD, Daams M, Pouwels PJ, Balk LJ, Tewarie PK, Killestein J, Uitdehaag BM, Geurts JJ, Barkhof F and Vrenken H: What explains gray matter atrophy in long-standing multiple sclerosis? Radiology. 272:832–842. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Tovar-Moll F, Evangelou IE, Chiu AW, Richert ND, Ostuni JL, Ohayon JM, Auh S, Ehrmantraut M, Talagala SL, McFarland HF and Bagnato F: Thalamic involvement and its impact on clinical disability in patients with multiple sclerosis: A diffusion tensor imaging study at 3T. AJNR Am J Neuroradiol. 30:1380–1386. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Kipp M, Wagenknecht N, Beyer C, Samer S, Wuerfel J and Nikoubashman O: Thalamus pathology in multiple sclerosis: From biology to clinical application. Cell Mol Life Sci. 72:1127–1147. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Sorgun MH, Yucesan C and Tegin C: Is malnutrition a problem for multiple sclerosis patients? J Clin Neurosci. 21:1603–1605. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen J, Zhou C, Zhu L, Yan X, Wang Y, Chen X and Fang S: Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis. Exp Ther Med 13: 91-96, 2017.
APA
Chen, J., Zhou, C., Zhu, L., Yan, X., Wang, Y., Chen, X., & Fang, S. (2017). Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis. Experimental and Therapeutic Medicine, 13, 91-96. https://doi.org/10.3892/etm.2016.3950
MLA
Chen, J., Zhou, C., Zhu, L., Yan, X., Wang, Y., Chen, X., Fang, S."Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis". Experimental and Therapeutic Medicine 13.1 (2017): 91-96.
Chicago
Chen, J., Zhou, C., Zhu, L., Yan, X., Wang, Y., Chen, X., Fang, S."Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis". Experimental and Therapeutic Medicine 13, no. 1 (2017): 91-96. https://doi.org/10.3892/etm.2016.3950
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Zhou C, Zhu L, Yan X, Wang Y, Chen X and Fang S: Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis. Exp Ther Med 13: 91-96, 2017.
APA
Chen, J., Zhou, C., Zhu, L., Yan, X., Wang, Y., Chen, X., & Fang, S. (2017). Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis. Experimental and Therapeutic Medicine, 13, 91-96. https://doi.org/10.3892/etm.2016.3950
MLA
Chen, J., Zhou, C., Zhu, L., Yan, X., Wang, Y., Chen, X., Fang, S."Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis". Experimental and Therapeutic Medicine 13.1 (2017): 91-96.
Chicago
Chen, J., Zhou, C., Zhu, L., Yan, X., Wang, Y., Chen, X., Fang, S."Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis". Experimental and Therapeutic Medicine 13, no. 1 (2017): 91-96. https://doi.org/10.3892/etm.2016.3950
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team