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Article Open Access

The effect of resveratrol on hypertension: A clinical trial

  • Authors:
    • Marios Theodotou
    • Konstantinos Fokianos
    • Alexia Mouzouridou
    • Cornelia Konstantinou
    • Andrea Aristotelous
    • Dafni Prodromou
    • Asimina Chrysikou
  • View Affiliations / Copyright

    Affiliations: Riegler, Ltd., Institute of Medical Clinical Trials, Limassol 3020, Cyprus, Department of Mathematics and Statistics, University of Cyprus, Nicosia 20537, Cyprus, Agios Efrem, Advanced Medical Diagnostic Center, Limassol 3020, Cyprus
    Copyright: © Theodotou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 295-301
    |
    Published online on: December 6, 2016
       https://doi.org/10.3892/etm.2016.3958
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Abstract

The aim of this clinical trial was to investigate the effects of Evelor, a micronized formulation of resveratrol (RESV; 3,5,4'-trihydroxy-trans-stilbene), in patients with primary hypertension. RESV is a stilbenoid and phytoalexin produced by several plants in response to injury or attack by pathogens, such as bacteria and fungi. Patients included in the clinical trial were split into the following two groups, based on the severity of their disease: Group A (n=46), stage I hypertension [systolic blood pressure (SBP), 140‑159 mmHg; diastolic blood pressure (DBP), 90‑99 mmHg] and Group B (n=51), stage II hypertension (SBP, 160‑179 mmHg; DBP, 100‑109 mmHg). Each group was divided into two subgroups: A1 and B1, patients treated with standard antihypertensive therapy (A1, 10 mg Dapril; B1, 20 mg Dapril), and A2 and B2, patients treated with antihypertensive therapy (Dapril) plus Evelor. The present study aimed to determine the effects of Evelor, in addition to the standard hypertension treatment, and its effect on the hepatic enzymes serum glutamate-pyruvate transaminase (SGPT) and gamma‑glutamyl transferase (gamma‑GT). Following the trial, which lasted two years (October 2010 to October 2012), the mean blood pressure of both groups lay within the normal range, indicating that blood pressure was efficiently controlled. The results of the present study demonstrate that the addition of RESV to standard antihypertensive therapy is sufficient to reduce blood pressure to normal levels, without the need for additional antihypertensive drugs. In addition, statistical analysis of the results identified a significant reduction in plasma concentration levels of SGPT (P<0.001) and gamma‑GT (P<0.001) with the addition of RESV, indicating that RESV prevents liver damage.
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Copy and paste a formatted citation
Spandidos Publications style
Theodotou M, Fokianos K, Mouzouridou A, Konstantinou C, Aristotelous A, Prodromou D and Chrysikou A: The effect of resveratrol on hypertension: A clinical trial. Exp Ther Med 13: 295-301, 2017.
APA
Theodotou, M., Fokianos, K., Mouzouridou, A., Konstantinou, C., Aristotelous, A., Prodromou, D., & Chrysikou, A. (2017). The effect of resveratrol on hypertension: A clinical trial. Experimental and Therapeutic Medicine, 13, 295-301. https://doi.org/10.3892/etm.2016.3958
MLA
Theodotou, M., Fokianos, K., Mouzouridou, A., Konstantinou, C., Aristotelous, A., Prodromou, D., Chrysikou, A."The effect of resveratrol on hypertension: A clinical trial". Experimental and Therapeutic Medicine 13.1 (2017): 295-301.
Chicago
Theodotou, M., Fokianos, K., Mouzouridou, A., Konstantinou, C., Aristotelous, A., Prodromou, D., Chrysikou, A."The effect of resveratrol on hypertension: A clinical trial". Experimental and Therapeutic Medicine 13, no. 1 (2017): 295-301. https://doi.org/10.3892/etm.2016.3958
Copy and paste a formatted citation
x
Spandidos Publications style
Theodotou M, Fokianos K, Mouzouridou A, Konstantinou C, Aristotelous A, Prodromou D and Chrysikou A: The effect of resveratrol on hypertension: A clinical trial. Exp Ther Med 13: 295-301, 2017.
APA
Theodotou, M., Fokianos, K., Mouzouridou, A., Konstantinou, C., Aristotelous, A., Prodromou, D., & Chrysikou, A. (2017). The effect of resveratrol on hypertension: A clinical trial. Experimental and Therapeutic Medicine, 13, 295-301. https://doi.org/10.3892/etm.2016.3958
MLA
Theodotou, M., Fokianos, K., Mouzouridou, A., Konstantinou, C., Aristotelous, A., Prodromou, D., Chrysikou, A."The effect of resveratrol on hypertension: A clinical trial". Experimental and Therapeutic Medicine 13.1 (2017): 295-301.
Chicago
Theodotou, M., Fokianos, K., Mouzouridou, A., Konstantinou, C., Aristotelous, A., Prodromou, D., Chrysikou, A."The effect of resveratrol on hypertension: A clinical trial". Experimental and Therapeutic Medicine 13, no. 1 (2017): 295-301. https://doi.org/10.3892/etm.2016.3958
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