Open Access

Chitosan hydrogel improves mesenchymal stem cell transplant survival and cardiac function following myocardial infarction in rats

  • Authors:
    • Bin Xu
    • Yang Li
    • Bo Deng
    • Xiaojing Liu
    • Lin Wang
    • Qing‑Lei Zhu
  • View Affiliations

  • Published online on: January 5, 2017     https://doi.org/10.3892/etm.2017.4026
  • Pages: 588-594
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Myocardial infarction (MI) remains the leading cause of cardiovascular‑associated mortality and morbidity. Improving the retention rate, survival and cardiomyocyte differentiation of mesenchymal stem cells (MSCs) is important in improving the treatment of patients with MI. In the present study, temperature‑responsive chitosan hydrogel, an injectable scaffold, was used to deliver MSCs directly into the infarcted myocardium of rats following MI. Histopathology and immunohistochemical staining were used to evaluate cardiac cell survival and regeneration, and cardiac function was assessed using an echocardiograph. It was demonstrated that chitosan hydrogel increased graft size and cell retention in the ischemic heart, promoted MSCs to differentiate into cardiomyocytes and increased the effects of MSCs on neovasculature formation. Furthermore, chitosan hydrogel enhanced the effect of MSCs on the improvement of cardiac function and hemodynamics in the infarcted area of rats following MI. These findings suggest that chitosan hydrogel is an appropriate material to deliver MSCs into infarcted myocardium.

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February-2017
Volume 13 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xu B, Li Y, Deng B, Liu X, Wang L and Zhu QL: Chitosan hydrogel improves mesenchymal stem cell transplant survival and cardiac function following myocardial infarction in rats. Exp Ther Med 13: 588-594, 2017
APA
Xu, B., Li, Y., Deng, B., Liu, X., Wang, L., & Zhu, Q. (2017). Chitosan hydrogel improves mesenchymal stem cell transplant survival and cardiac function following myocardial infarction in rats. Experimental and Therapeutic Medicine, 13, 588-594. https://doi.org/10.3892/etm.2017.4026
MLA
Xu, B., Li, Y., Deng, B., Liu, X., Wang, L., Zhu, Q."Chitosan hydrogel improves mesenchymal stem cell transplant survival and cardiac function following myocardial infarction in rats". Experimental and Therapeutic Medicine 13.2 (2017): 588-594.
Chicago
Xu, B., Li, Y., Deng, B., Liu, X., Wang, L., Zhu, Q."Chitosan hydrogel improves mesenchymal stem cell transplant survival and cardiac function following myocardial infarction in rats". Experimental and Therapeutic Medicine 13, no. 2 (2017): 588-594. https://doi.org/10.3892/etm.2017.4026