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Morphine and pregabalin in the treatment of neuropathic pain

  • Authors:
    • Yue Wang
    • Helen Yang
    • Chunjian Shen
    • Ji Luo
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China, Institute of Public Health, University of California, San Francisco, CA 94117‑1080, USA, Department of General Surgery, The Second Hospital of Shenyang Medical College, Shenyang, Liaoning 110000, P.R. China, Department of General Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1393-1397
    |
    Published online on: February 7, 2017
       https://doi.org/10.3892/etm.2017.4102
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Abstract

The drugs that are currently available to treat neuropathic pain exhibit inadequate efficacy and numerous adverse effects. The present study compared the efficacy of combination therapy with pregabalin and morphine with that of each as a single agent in patients with neuropathic pain. The primary measurement was mean daily pain intensity. Secondary measurements included a pain questionnaire, adverse effects, mood and quality of life. Combination therapy of morphine plus pregabalin and morphine monotherapy were both more effective at reducing neuropathic pain than pregabalin monotherapy. Furthermore, patients in the combination group noted that their quality of life markedly improved from the baseline, as compared with the patients in the other two groups. These findings indicate that combination therapy with morphine and pregabalin may be used as a valuable therapy for neuropathic pain.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Yang H, Shen C and Luo J: Morphine and pregabalin in the treatment of neuropathic pain. Exp Ther Med 13: 1393-1397, 2017.
APA
Wang, Y., Yang, H., Shen, C., & Luo, J. (2017). Morphine and pregabalin in the treatment of neuropathic pain. Experimental and Therapeutic Medicine, 13, 1393-1397. https://doi.org/10.3892/etm.2017.4102
MLA
Wang, Y., Yang, H., Shen, C., Luo, J."Morphine and pregabalin in the treatment of neuropathic pain". Experimental and Therapeutic Medicine 13.4 (2017): 1393-1397.
Chicago
Wang, Y., Yang, H., Shen, C., Luo, J."Morphine and pregabalin in the treatment of neuropathic pain". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1393-1397. https://doi.org/10.3892/etm.2017.4102
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Yang H, Shen C and Luo J: Morphine and pregabalin in the treatment of neuropathic pain. Exp Ther Med 13: 1393-1397, 2017.
APA
Wang, Y., Yang, H., Shen, C., & Luo, J. (2017). Morphine and pregabalin in the treatment of neuropathic pain. Experimental and Therapeutic Medicine, 13, 1393-1397. https://doi.org/10.3892/etm.2017.4102
MLA
Wang, Y., Yang, H., Shen, C., Luo, J."Morphine and pregabalin in the treatment of neuropathic pain". Experimental and Therapeutic Medicine 13.4 (2017): 1393-1397.
Chicago
Wang, Y., Yang, H., Shen, C., Luo, J."Morphine and pregabalin in the treatment of neuropathic pain". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1393-1397. https://doi.org/10.3892/etm.2017.4102
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