Open Access

Morphine and pregabalin in the treatment of neuropathic pain

  • Authors:
    • Yue Wang
    • Helen Yang
    • Chunjian Shen
    • Ji Luo
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  • Published online on: February 7, 2017     https://doi.org/10.3892/etm.2017.4102
  • Pages: 1393-1397
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The drugs that are currently available to treat neuropathic pain exhibit inadequate efficacy and numerous adverse effects. The present study compared the efficacy of combination therapy with pregabalin and morphine with that of each as a single agent in patients with neuropathic pain. The primary measurement was mean daily pain intensity. Secondary measurements included a pain questionnaire, adverse effects, mood and quality of life. Combination therapy of morphine plus pregabalin and morphine monotherapy were both more effective at reducing neuropathic pain than pregabalin monotherapy. Furthermore, patients in the combination group noted that their quality of life markedly improved from the baseline, as compared with the patients in the other two groups. These findings indicate that combination therapy with morphine and pregabalin may be used as a valuable therapy for neuropathic pain.
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April-2017
Volume 13 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang Y, Yang H, Shen C and Luo J: Morphine and pregabalin in the treatment of neuropathic pain. Exp Ther Med 13: 1393-1397, 2017
APA
Wang, Y., Yang, H., Shen, C., & Luo, J. (2017). Morphine and pregabalin in the treatment of neuropathic pain. Experimental and Therapeutic Medicine, 13, 1393-1397. https://doi.org/10.3892/etm.2017.4102
MLA
Wang, Y., Yang, H., Shen, C., Luo, J."Morphine and pregabalin in the treatment of neuropathic pain". Experimental and Therapeutic Medicine 13.4 (2017): 1393-1397.
Chicago
Wang, Y., Yang, H., Shen, C., Luo, J."Morphine and pregabalin in the treatment of neuropathic pain". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1393-1397. https://doi.org/10.3892/etm.2017.4102