Therapeutic efficacy of phentolamine in the management of severe hand, foot and mouth disease combined with pulmonary edema

Yan,Zhixin; Shang,Yaokai; Li,Fengxian; Xie,Fei; Qian,Huili; Zhang,Youqi; Yue,Bin

doi:10.3892/etm.2017.4104

Therapeutic efficacy of phentolamine in the management of severe hand, foot and mouth disease combined with pulmonary edema

Authors:
- Zhixin Yan
- Yaokai Shang
- Fengxian Li
- Fei Xie
- Huili Qian
- Youqi Zhang
- Bin Yue
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Affiliations: Department of First Pediatric Internal Medicine, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China, Department of Pediatrics, Yanshan Fude Hospital, Cangzhou, Hebei 061000, P.R. China, Department of Internal Medicine, Yanshan Fude Hospital, Cangzhou, Hebei 061000, P.R. China, Department of Second Pediatric Internal Medicine, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China, Department of Fourth Pediatric Internal Medicine, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China
Published online on: February 7, 2017 https://doi.org/10.3892/etm.2017.4104
Pages: 1403-1407
Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of this study was to examine the effects of phentolamine on severe hand, foot and mouth disease (HFMD) combined with pulmonary edema (PE). From May 2008 to December 2012, 53 children with severe HFMD plus PE were enrolled in the treatment group, receiving phentolamine intravenously at a loading dose of 5 µg/kg/min. The control group comprised 52 children with the same disease who did not receive phentolamine infusion. Data concerning creatine kinase (CK), CK‑MB, cardiac troponin I (cTnI), heart rate, systolic blood pressure (SBP) and the duration of ventilation dependence and hospitalization were collected. Adverse events were also recorded. It was found that the phentolamine‑treated patients exhibited significantly lower CK, CK‑MB and cTnI levels, heart rate and SBP than the controls (P<0.01 for all parameters). The average duration of ventilator dependence and hospitalization was significantly shorter (P<0.01) in the phentolamine group than in the control group. It was also found that the overall mortality rate was lower in the phentolamine group (5.8%) than in the control group (11.5%). No adverse events were observed in either group. Thus, these results offer preliminary evidence that phentolamine reduces mortality and relieves the symptoms of EV71‑induced PE. Phentolamine is a potential therapeutic agent for this highly lethal disorder.

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